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Comparative and Functional Genomics
Volume 2012 (2012), Article ID 564381, 10 pages
Review Article

Epigenetic Regulation of B Lymphocyte Differentiation, Transdifferentiation, and Reprogramming

1Cellular Differentiation Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Avenida Gran Via s/n km 2.7, 08907 L’Hospitalet de Llobregat, Barcelona, Spain
2Department of Biochemistry, Erasmus University Medical Center, Ee622, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands

Received 7 February 2012; Revised 21 May 2012; Accepted 6 July 2012

Academic Editor: Sonia Vanina Forcales

Copyright © 2012 Bruna Barneda-Zahonero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


B cell development is a multistep process that is tightly regulated at the transcriptional level. In recent years, investigators have shed light on the transcription factor networks involved in all the differentiation steps comprising B lymphopoiesis. The interplay between transcription factors and the epigenetic machinery involved in establishing the correct genomic landscape characteristic of each cellular state is beginning to be dissected. The participation of “epigenetic regulator-transcription factor” complexes is also crucial for directing cells during reprogramming into pluripotency or lineage conversion. In this context, greater knowledge of epigenetic regulation during B cell development, transdifferentiation, and reprogramming will enable us to understand better how epigenetics can control cell lineage commitment and identity. Herein, we review the current knowledge about the epigenetic events that contribute to B cell development and reprogramming.