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International Journal of Genomics
Volume 2016 (2016), Article ID 2405954, 14 pages
http://dx.doi.org/10.1155/2016/2405954
Review Article

Role of Recombinant DNA Technology to Improve Life

1The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China
2Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
3Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar 25000, Pakistan
4National Key Laboratory of Crop Genetic Improvement, College of Plant Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, China
5Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan 430074, China

Received 10 August 2016; Revised 21 October 2016; Accepted 6 November 2016

Academic Editor: Wenqin Wang

Copyright © 2016 Suliman Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Kumar and A. Kumar, “Role of genetic engineering in agriculture,” Plant Archives, vol. 15, pp. 1–6, 2015. View at Google Scholar
  2. T. Cardi and C. N. Stewart Jr., “Progress of targeted genome modification approaches in higher plants,” Plant Cell Reports, vol. 35, no. 7, pp. 1401–1416, 2016. View at Publisher · View at Google Scholar
  3. P. T. Lomedico, “Use of recombinant DNA technology to program eukaryotic cells to synthesize rat proinsulin: a rapid expression assay for cloned genes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 79, no. 19, pp. 5798–5802, 1982. View at Publisher · View at Google Scholar · View at Scopus
  4. M. W. Ullah, W. A. Khattak, M. Ul-Islam, S. Khan, and J. K. Park, “Encapsulated yeast cell-free system: a strategy for cost-effective and sustainable production of bio-ethanol in consecutive batches,” Biotechnology and Bioprocess Engineering, vol. 20, no. 3, pp. 561–575, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. M. W. Ullah, W. A. Khattak, M. Ul-Islam, S. Khan, and J. K. Park, “Bio-ethanol production through simultaneous saccharification and fermentation using an encapsulated reconstituted cell-free enzyme system,” Biochemical Engineering Journal, vol. 91, pp. 110–119, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. W. A. Khattak, M. Ul-Islam, M. W. Ullah, B. Yu, S. Khan, and J. K. Park, “Yeast cell-free enzyme system for bio-ethanol production at elevated temperatures,” Process Biochemistry, vol. 49, no. 3, pp. 357–364, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. W. A. Khattak, M. W. Ullah, M. Ul-Islam et al., “Developmental strategies and regulation of cell-free enzyme system for ethanol production: a molecular prospective,” Applied Microbiology and Biotechnology, vol. 98, no. 23, pp. 9561–9578, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Galambos and J. L. Sturchio, “Pharmaceutical firms and the transition to biotechnology: a study in strategic innovation,” Business History Review, vol. 72, no. 2, pp. 250–278, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. F. M. Steinberg and J. Raso, “Biotech pharmaceuticals and biotherapy: an overview,” Journal of Pharmacy and Pharmaceutical Science, vol. 1, no. 2, pp. 48–59, 1998. View at Google Scholar · View at Scopus
  10. W. Liu, J. S. Yuan, and C. N. Stewart Jr., “Advanced genetic tools for plant biotechnology,” Nature Reviews Genetics, vol. 14, no. 11, pp. 781–793, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Venter, “Synthetic promoters: genetic control through cis engineering,” Trends in Plant Science, vol. 12, no. 3, pp. 118–124, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Berk and S. L. Zipursky, Molecular Cell Biology, vol. 4, WH Freeman, New York, NY, USA, 2000.
  13. M. Bazan-Peregrino, R. C. A. Sainson, R. C. Carlisle et al., “Combining virotherapy and angiotherapy for the treatment of breast cancer,” Cancer Gene Therapy, vol. 20, no. 8, pp. 461–468, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. L.-X. Li, Y.-L. Zhang, L. Zhou et al., “Antitumor efficacy of a recombinant adenovirus encoding endostatin combined with an E1B55KD-deficient adenovirus in gastric cancer cells,” Journal of Translational Medicine, vol. 11, no. 1, article 257, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Méndez and J. A. Salas, “On the generation of novel anticancer drugs by recombinant DNA technology: the use of combinatorial biosynthesis to produce novel drugs,” Combinatorial Chemistry — High Throughput Screening, vol. 6, no. 6, pp. 513–526, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. B. C. J. M. Fauser, B. M. J. L. Mannaerts, P. Devroey, A. Leader, I. Boime, and D. T. Baird, “Advances in recombinant DNA technology: corifollitropin alfa, a hybrid molecule with sustained follicle-stimulating activity and reduced injection frequency,” Human Reproduction Update, vol. 15, no. 3, pp. 309–321, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. O. Merten and B. Gaillet, “Viral vectors for gene therapy and gene modification approaches,” Biochemical Engineering Journal, vol. 108, pp. 98–115, 2016. View at Publisher · View at Google Scholar
  18. O.-W. Merten, M. Schweizer, P. Chahal, and A. A. Kamen, “Manufacturing of viral vectors for gene therapy: part I. Upstream processing,” Pharmaceutical Bioprocessing, vol. 2, no. 2, pp. 183–203, 2014. View at Publisher · View at Google Scholar
  19. S. L. Ginn, I. E. Alexander, M. L. Edelstein, M. R. Abedi, and J. Wixon, “Gene therapy clinical trials worldwide to 2012—an update,” Journal of Gene Medicine, vol. 15, no. 2, pp. 65–77, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Rivero-Müller, S. Lajić, and I. Huhtaniemi, “Assisted large fragment insertion by Red/ET-recombination (ALFIRE)—an alternative and enhanced method for large fragment recombineering,” Nucleic Acids Research, vol. 35, no. 10, article e78, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. L. E. Metzger IV and C. R. H. Raetz, “Purification and characterization of the lipid A disaccharide synthase (LpxB) from Escherichia coli, a peripheral membrane protein,” Biochemistry, vol. 48, no. 48, pp. 11559–11571, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. E. A. Masson, J. E. Patmore, P. D. Brash et al., “Pregnancy outcome in Type 1 diabetes mellitus treated with insulin lispro (Humalog),” Diabetic Medicine, vol. 20, no. 1, pp. 46–50, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. A. K. Patra, R. Mukhopadhyay, R. Mukhija, A. Krishnan, L. C. Garg, and A. K. Panda, “Optimization of inclusion body solubilization and renaturation of recombinant human growth hormone from Escherichia coil,” Protein Expression and Purification, vol. 18, no. 2, pp. 182–192, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. D. C. Macallan, C. Baldwin, S. Mandalia et al., “Treatment of altered body composition in HIV-associated lipodystrophy: comparison of rosiglitazone, pravastatin, and recombinant human growth hormone,” HIV Clinical Trials, vol. 9, no. 4, pp. 254–268, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Pennisi, “The CRISPR craze,” Science, vol. 341, no. 6148, pp. 833–836, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Wang, M. Li, L. Gong, S. Hu, and H. Xiang, “DNA motifs determining the accuracy of repeat duplication during CRISPR adaptation in Haloarcula hispanica,” Nucleic Acids Research, vol. 44, no. 9, pp. 4266–4277, 2016. View at Publisher · View at Google Scholar
  27. S. Shmakov, O. O. Abudayyeh, K. S. Makarova et al., “Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems,” Molecular Cell, vol. 60, no. 3, pp. 385–397, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Gasiunas and V. Siksnys, “RNA-dependent DNA endonuclease Cas9 of the CRISPR system: holy grail of genome editing?” Trends in Microbiology, vol. 21, no. 11, pp. 562–567, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Mohanraju, K. S. Makarova, B. Zetsche, F. Zhang, E. V. Koonin, and J. van der Oost, “Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems,” Science, vol. 353, no. 6299, 2016. View at Publisher · View at Google Scholar
  30. V. K. Vyas, M. I. Barrasa, and G. R. Fink, “A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families,” Science Advances, vol. 1, no. 3, Article ID e1500248, 2015. View at Publisher · View at Google Scholar
  31. A. P. Hynes, S. J. Labrie, and S. Moineau, “Programming native CRISPR arrays for the generation of targeted immunity,” mBio, vol. 7, no. 3, p. e00202-16, 2016. View at Publisher · View at Google Scholar
  32. F. Hille and E. Charpentier, “CRISPR-Cas: biology, mechanisms and relevance,” Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 371, no. 1707, Article ID 20150496, 2016. View at Publisher · View at Google Scholar
  33. K. S. Makarova, Y. I. Wolf, O. S. Alkhnbashi et al., “An updated evolutionary classification of CRISPR-Cas systems,” Nature Reviews Microbiology, vol. 13, no. 11, pp. 722–736, 2015. View at Publisher · View at Google Scholar · View at Scopus
  34. D. Rath, L. Amlinger, A. Rath, and M. Lundgren, “The CRISPR-Cas immune system: biology, mechanisms and applications,” Biochimie, vol. 117, pp. 119–128, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. G. Liu, Q. She, and R. A. Garrett, “Diverse CRISPR-Cas responses and dramatic cellular DNA changes and cell death in pKEF9-conjugated Sulfolobus species,” Nucleic Acids Research, vol. 44, no. 9, pp. 4233–4242, 2016. View at Publisher · View at Google Scholar
  36. T. Gaj, C. A. Gersbach, and C. F. Barbas, “ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering,” Trends in Biotechnology, vol. 31, no. 7, pp. 397–405, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. P. R. Blackburn, J. M. Campbell, K. J. Clark, and S. C. Ekker, “The CRISPR system—keeping zebrafish gene targeting fresh,” Zebrafish, vol. 10, no. 1, pp. 116–118, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. G. D. Yancopoulos, S. Davis, N. W. Gale, J. S. Rudge, S. J. Wiegand, and J. Holash, “Vascular-specific growth factors and blood vessel formation,” Nature, vol. 407, no. 6801, pp. 242–248, 2000. View at Publisher · View at Google Scholar · View at Scopus
  39. R. K. Jain, P. Au, J. Tam, D. G. Duda, and D. Fukumura, “Engineering vascularized tissue,” Nature Biotechnology, vol. 23, no. 7, pp. 821–823, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. K. Naoto, F. Dai, G. Oliver, A. Patrick, S. S. Jeffrey, and K. J. Rakesh, “Tissue engineering: creation of long-lasting blood vessels,” Nature, vol. 428, pp. 138–139, 2004. View at Google Scholar
  41. N. Ferrer-Miralles, J. Domingo-Espín, J. Corchero, E. Vázquez, and A. Villaverde, “Microbial factories for recombinant pharmaceuticals,” Microbial Cell Factories, vol. 8, article 17, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Kamionka, “Engineering of therapeutic proteins production in Escherichia coli,” Current Pharmaceutical Biotechnology, vol. 12, no. 2, pp. 268–274, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Eriksson, “Enzymatic synthesis of nucleoside triphosphates,” in Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, vol. 23, 2016. View at Google Scholar
  44. D. J. Urban and B. L. Roth, “DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility,” Annual Review of Pharmacology and Toxicology, vol. 55, pp. 399–417, 2015. View at Publisher · View at Google Scholar · View at Scopus
  45. J. S. Tzartos, M. A. Friese, M. J. Craner et al., “Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis,” The American Journal of Pathology, vol. 172, no. 1, pp. 146–155, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. K. Rabe, M. Lehrke, K. G. Parhofer, and U. C. Broedl, “Adipokines and insulin resistance,” Molecular Medicine, vol. 14, no. 11-12, pp. 741–751, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. Z. S. Olempska-Beer, R. I. Merker, M. D. Ditto, and M. J. DiNovi, “Food-processing enzymes from recombinant microorganisms—a review,” Regulatory Toxicology and Pharmacology, vol. 45, no. 2, pp. 144–158, 2006. View at Publisher · View at Google Scholar · View at Scopus
  48. Z.-X. Lian, Z.-S. Ma, J. Wei, and H. Liu, “Preparation and characterization of immobilized lysozyme and evaluation of its application in edible coatings,” Process Biochemistry, vol. 47, no. 2, pp. 201–208, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. S. H. Bang, A. Jang, J. Yoon et al., “Evaluation of whole lysosomal enzymes directly immobilized on titanium (IV) oxide used in the development of antimicrobial agents,” Enzyme and Microbial Technology, vol. 49, no. 3, pp. 260–265, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. B. Thallinger, E. N. Prasetyo, G. S. Nyanhongo, and G. M. Guebitz, “Antimicrobial enzymes: an emerging strategy to fight microbes and microbial biofilms,” Biotechnology Journal, vol. 8, no. 1, pp. 97–109, 2013. View at Publisher · View at Google Scholar · View at Scopus
  51. C. E. Torres, G. Lenon, D. Craperi, R. Wilting, and Á. Blanco, “Enzymatic treatment for preventing biofilm formation in the paper industry,” Applied Microbiology and Biotechnology, vol. 92, no. 1, pp. 95–103, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. J. K.-C. Ma, P. M. W. Drake, and P. Christou, “The production of recombinant pharmaceutical proteins in plants,” Nature Reviews Genetics, vol. 4, no. 10, pp. 794–805, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. R. Gamuyao, J. H. Chin, J. Pariasca-Tanaka et al., “The protein kinase Pstol1 from traditional rice confers tolerance of phosphorus deficiency,” Nature, vol. 488, no. 7412, pp. 535–539, 2012. View at Publisher · View at Google Scholar · View at Scopus
  54. K. Hiruma, N. Gerlach, S. Sacristán et al., “Root endophyte Colletotrichum tofieldiae confers plant fitness benefits that are phosphate status dependent,” Cell, vol. 165, no. 2, pp. 464–474, 2016. View at Publisher · View at Google Scholar
  55. S. Jin and H. Daniell, “The engineered chloroplast genome just got smarter,” Trends in Plant Science, vol. 20, no. 10, pp. 622–640, 2015. View at Publisher · View at Google Scholar · View at Scopus
  56. D. J. Oldenburg and A. J. Bendich, “DNA maintenance in plastids and mitochondria of plants,” Frontiers in Plant Science, vol. 6, article 883, 2015. View at Publisher · View at Google Scholar · View at Scopus
  57. D. Henry, L. Choun-Sea, Y. Ming, and C. Wan-Jung, “Chloroplast genomes: diversity, evolution, and applications in genetic engineering,” Genome Biology, vol. 17, article 134, 2016. View at Publisher · View at Google Scholar
  58. W. Apel and R. Bock, “Enhancement of carotenoid biosynthesis in transplastomic tomatoes by induced lycopene-to-provitamin A conversion,” Plant Physiology, vol. 151, no. 1, pp. 59–66, 2009. View at Publisher · View at Google Scholar · View at Scopus
  59. T. Oikawa, H. Maeda, T. Oguchi et al., “The birth of a black rice gene and its local spread by introgression,” Plant Cell, vol. 27, no. 9, pp. 2401–2414, 2015. View at Publisher · View at Google Scholar · View at Scopus
  60. Y. Oono, T. Yazawa, Y. Kawahara et al., “Genome-wide transcriptome analysis reveals that cadmium stress signaling controls the expression of genes in drought stress signal pathways in rice,” PLoS ONE, vol. 9, no. 5, Article ID e96946, 2014. View at Publisher · View at Google Scholar · View at Scopus
  61. European Commission, Restrictions of geographical scope of GMO applications/authorisations: Member States demands and outcomes, 2015, http://ec.europa.eu/food/plant/gmo/authorisation.
  62. M. Cavazzana-Calvo, S. Hacein-Bey, G. De Saint Basile et al., “Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease,” Science, vol. 288, no. 5466, pp. 669–672, 2000. View at Publisher · View at Google Scholar · View at Scopus
  63. S. Hacein-Bey-Abina, F. Le Deist, F. Carlier et al., “Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy,” The New England Journal of Medicine, vol. 346, no. 16, pp. 1185–1193, 2002. View at Publisher · View at Google Scholar · View at Scopus
  64. S. J. Howe, M. R. Mansour, K. Schwarzwaelder et al., “Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients,” Journal of Clinical Investigation, vol. 118, no. 9, pp. 3143–3150, 2008. View at Publisher · View at Google Scholar · View at Scopus
  65. R. M. Blaese, K. W. Culver, A. D. Miller et al., “T lymphocyte-directed gene therapy for ADA-SCID: initial trial results after 4 years,” Science, vol. 270, no. 5235, pp. 475–480, 1995. View at Publisher · View at Google Scholar · View at Scopus
  66. A. Aiuti, S. Vai, A. Mortellaro et al., “Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement,” Nature Medicine, vol. 8, no. 5, pp. 423–425, 2002. View at Publisher · View at Google Scholar · View at Scopus
  67. N. Cartier, S. Hacein-Bey-Abina, C. C. Bartholomae et al., “Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy,” Science, vol. 326, no. 5954, pp. 818–823, 2009. View at Publisher · View at Google Scholar · View at Scopus
  68. E. Montini, A. Biffi, A. Calabria et al., “Integration site analysis in a clinical trial of lentiviral vector based haematopoietic stem cell gene therapy for meatchromatic leukodystrophy,” Human Gene Therapy, vol. 23, article A13, 2012. View at Google Scholar
  69. R. A. Morgan, M. E. Dudley, J. R. Wunderlich et al., “Cancer regression in patients after transfer of genetically engineered lymphocytes,” Science, vol. 314, no. 5796, pp. 126–129, 2006. View at Publisher · View at Google Scholar · View at Scopus
  70. P. F. Robbins, R. A. Morgan, S. A. Feldman et al., “Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1,” Journal of Clinical Oncology, vol. 29, no. 7, pp. 917–924, 2011. View at Publisher · View at Google Scholar · View at Scopus
  71. J. E. Adair, B. C. Beard, G. D. Trobridge et al., “Extended survival of glioblastoma patients after chemoprotective HSC gene therapy,” Science Translational Medicine, vol. 4, no. 133, Article ID 133ra57, 2012. View at Publisher · View at Google Scholar · View at Scopus
  72. M. G. Ott, M. Schmidt, K. Schwarzwaelder et al., “Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1,” Nature Medicine, vol. 12, no. 4, pp. 401–409, 2006. View at Publisher · View at Google Scholar · View at Scopus
  73. S. Stein, M. G. Ott, S. Schultze-Strasser et al., “Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease,” Nature Medicine, vol. 16, no. 2, pp. 198–204, 2010. View at Publisher · View at Google Scholar · View at Scopus
  74. J. Zhang, E. B. Tarbet, H. Toro, and D.-C. C. Tang, “Adenovirus-vectored drug-vaccine duo as a potential driver for conferring mass protection against infectious diseases,” Expert Review of Vaccines, vol. 10, no. 11, pp. 1539–1552, 2011. View at Publisher · View at Google Scholar · View at Scopus
  75. P. Lam, G. Khan, R. Stripecke et al., “The innovative evolution of cancer gene and cellular therapies,” Cancer Gene Therapy, vol. 20, no. 3, pp. 141–149, 2013. View at Publisher · View at Google Scholar · View at Scopus
  76. A. Aiuti, L. Biasco, S. Scaramuzza et al., “Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome,” Science, vol. 341, no. 6148, Article ID 1233151, 2013. View at Publisher · View at Google Scholar · View at Scopus
  77. N. P. Restifo, M. E. Dudley, and S. A. Rosenberg, “Adoptive immunotherapy for cancer: harnessing the T cell response,” Nature Reviews Immunology, vol. 12, no. 4, pp. 269–281, 2012. View at Publisher · View at Google Scholar · View at Scopus
  78. M. H. Kershaw, J. A. Westwood, and P. K. Darcy, “Gene-engineered T cells for cancer therapy,” Nature Reviews Cancer, vol. 13, no. 8, pp. 525–541, 2013. View at Publisher · View at Google Scholar · View at Scopus
  79. M. Danilo, M. Eusebio, P. C. Carla et al., “In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system,” Nature, vol. 516, no. 7531, pp. 423–427, 2014. View at Publisher · View at Google Scholar
  80. L. Jun, P. Shifeng, H. H. Mindy, and N. Nicholas, Targeting Wnt-Driven Cancer through the Inhibition of Porcupine by LGK974, MRC Laboratory of Molecular Biology, Cambridge, UK, 2013.
  81. J. H. C. M. Kreijtz, L. C. M. Wiersma, H. L. M. De Gruyter et al., “A single immunization with modified vaccinia virus Ankara-based influenza virus H7 vaccine affords protection in the influenza A(H7N9) pneumonia ferret model,” The Journal of Infectious Diseases, vol. 211, no. 5, pp. 791–800, 2015. View at Publisher · View at Google Scholar · View at Scopus
  82. J. P. Hughes, G. Alusi, and Y. Wang, “Viral gene therapy for head and neck cancer,” The Journal of Laryngology & Otology, vol. 129, no. 4, pp. 314–320, 2015. View at Publisher · View at Google Scholar · View at Scopus
  83. J. D. Smith, “Human Macrophage Genetic Engineering,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 36, no. 1, pp. 2–3, 2016. View at Publisher · View at Google Scholar · View at Scopus
  84. E. Stöger, C. Vaquero, E. Torres et al., “Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies,” Plant Molecular Biology, vol. 42, no. 4, pp. 583–590, 2000. View at Publisher · View at Google Scholar · View at Scopus
  85. C. Vaquero, M. Sack, F. Schuster et al., “A carcinoembryonic antigen-specific diabody produced in tobacco,” The FASEB journal, vol. 16, no. 3, pp. 408–410, 2002. View at Google Scholar · View at Scopus
  86. E. Karrer, S. H. Bass, R. Whalen, and P. A. Patten, U.S. Patent No. 8,252,727, 2012.
  87. R. M. Ionescu, J. Vlasak, C. Price, and M. Kirchmeier, “Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies,” Journal of Pharmaceutical Sciences, vol. 97, no. 4, pp. 1414–1426, 2008. View at Publisher · View at Google Scholar · View at Scopus
  88. C. W. Adams, D. E. Allison, K. Flagella et al., “Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab,” Cancer Immunology, Immunotherapy, vol. 55, no. 6, pp. 717–727, 2006. View at Publisher · View at Google Scholar · View at Scopus
  89. A. A. McCormick, S. Reddy, S. J. Reinl et al., “Plant-produced idiotype vaccines for the treatment of non-Hodgkin's lymphoma: safety and immunogenicity in a phase I clinical study,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 29, pp. 10131–10136, 2008. View at Publisher · View at Google Scholar · View at Scopus
  90. M. Bendandi, S. Marillonnet, R. Kandzia et al., “Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin's lymphoma,” Annals of Oncology, vol. 21, no. 12, pp. 2420–2427, 2010. View at Publisher · View at Google Scholar · View at Scopus
  91. S. Kathuria, R. Sriraman, R. Nath et al., “Efficacy of plant-produced recombinant antibodies against HCG,” Human Reproduction, vol. 17, no. 8, pp. 2054–2061, 2002. View at Publisher · View at Google Scholar · View at Scopus
  92. A. Rostami-Hodjegan and G. T. Tucker, “Simulation and prediction of in vivo drug metabolism in human populations from in vitro data,” Nature Reviews Drug Discovery, vol. 6, no. 2, pp. 140–148, 2007. View at Publisher · View at Google Scholar · View at Scopus
  93. J. K. Nicholson, E. Holmes, and I. D. Wilson, “Gut microorganisms, mammalian metabolism and personalized health care,” Nature Reviews Microbiology, vol. 3, no. 5, pp. 431–438, 2005. View at Publisher · View at Google Scholar · View at Scopus
  94. Q. R. Fan and W. A. Hendrickson, “Structure of human follicle-stimulating hormone in complex with its receptor,” Nature, vol. 433, no. 7023, pp. 269–277, 2005. View at Publisher · View at Google Scholar · View at Scopus
  95. M. Assidi, I. Dufort, A. Ali et al., “Identification of potential markers of oocyte competence expressed in bovine cumulus cells matured with follicle-stimulating hormone and/or phorbol myristate acetate in vitro,” Biology of Reproduction, vol. 79, no. 2, pp. 209–222, 2008. View at Publisher · View at Google Scholar · View at Scopus
  96. Z.-B. Hu and M. Du, “Hairy root and its application in plant genetic engineering,” Journal of Integrative Plant Biology, vol. 48, no. 2, pp. 121–127, 2006. View at Publisher · View at Google Scholar · View at Scopus
  97. C.-Q. Ling, L.-N. Wang, Y. Wang et al., “The roles of traditional Chinese medicine in gene therapy,” Journal of integrative medicine, vol. 12, no. 2, pp. 67–75, 2014. View at Publisher · View at Google Scholar · View at Scopus
  98. L. Mazzoni, P. Perez-Lopez, F. Giampieri et al., “The genetic aspects of berries: from field to health,” Journal of the Science of Food and Agriculture, vol. 96, no. 2, pp. 365–371, 2016. View at Publisher · View at Google Scholar · View at Scopus
  99. S. Ripp, D. E. Nivens, Y. Ahn et al., “Controlled field release of a bioluminescent genetically engineered microorganism for bioremediation process monitoring and control,” Environmental Science and Technology, vol. 34, no. 5, pp. 846–853, 2000. View at Publisher · View at Google Scholar · View at Scopus
  100. G. S. Sayler, C. D. Cox, R. Burlage et al., “Field application of a genetically engineered microorganism for polycyclic aromatic hydrocarbon bioremediation process monitoring and control,” in Novel Approaches for Bioremediation of Organic Pollution, pp. 241–254, Springer, New York, NY, USA, 1999. View at Publisher · View at Google Scholar
  101. J. M. H. King, P. M. DiGrazia, B. Applegate et al., “Rapid, sensitive bioluminescent reporter technology for naphthalene exposure and biodegradation,” Science, vol. 249, no. 4970, pp. 778–781, 1990. View at Publisher · View at Google Scholar · View at Scopus
  102. J. Chatterjee and E. A. Meighen, “Biotechnological applications of bacterial bioluminescence (lux) genes,” Photochemistry and Photobiology, vol. 62, no. 4, pp. 641–650, 1995. View at Publisher · View at Google Scholar
  103. K. Matsui, J. Togami, J. G. Mason, S. F. Chandler, and Y. Tanaka, “Enhancement of phosphate absorption by garden plants by genetic engineering: a new tool for phytoremediation,” BioMed Research International, vol. 2013, Article ID 182032, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  104. R. B. Horsch, J. E. Fry, N. L. Hoffmann, D. Eichholtz, S. G. Rogers, and R. T. Fraley, “A simple and general method for transferring genes into plants,” Science, vol. 227, no. 4691, pp. 1229–1230, 1985. View at Publisher · View at Google Scholar · View at Scopus
  105. M. Tamura, J. Togami, K. Ishiguro et al., “Regeneration of transformed verbena (verbena × hybrida) by Agrobacterium tumefaciens,” Plant Cell Reports, vol. 21, no. 5, pp. 459–466, 2003. View at Publisher · View at Google Scholar · View at Scopus
  106. J. M. Jez, S. G. Lee, and A. M. Sherp, “The next green movement: plant biology for the environment and sustainability,” Science, vol. 353, no. 6305, pp. 1241–1244, 2016. View at Publisher · View at Google Scholar
  107. S. Clemens and J. F. Ma, “Toxic heavy metal and metalloid accumulation in crop plants and foods,” Annual Review of Plant Biology, vol. 67, no. 1, pp. 489–512, 2016. View at Publisher · View at Google Scholar
  108. E.-J. Kim, J.-H. Youn, C.-H. Park et al., “Oligomerization between BSU1 family members potentiates brassinosteroid signaling in Arabidopsis,” Molecular Plant, vol. 9, no. 1, pp. 178–181, 2016. View at Publisher · View at Google Scholar · View at Scopus
  109. D. Mani and C. Kumar, “Biotechnological advances in bioremediation of heavy metals contaminated ecosystems: an overview with special reference to phytoremediation,” International Journal of Environmental Science and Technology, vol. 11, no. 3, pp. 843–872, 2014. View at Publisher · View at Google Scholar · View at Scopus
  110. M. W. Ullah, M. Ul-Islam, S. Khan, Y. Kim, and J. K. Park, “Structural and physico-mechanical characterization of bio-cellulose produced by a cell-free system,” Carbohydrate Polymers, vol. 136, pp. 908–916, 2016. View at Publisher · View at Google Scholar · View at Scopus
  111. M. W. Ullah, M. Ul-Islam, S. Khan, Y. Kim, and J. K. Park, “Innovative production of bio-cellulose using a cell-free system derived from a single cell line,” Carbohydrate Polymers, vol. 132, pp. 286–294, 2015. View at Publisher · View at Google Scholar · View at Scopus
  112. M. W. Ullah, W. A. Khattak, M. Ul-Islam, S. Khan, and J. K. Park, “Metabolic engineering of synthetic cell-free systems: strategies and applications,” Biochemical Engineering Journal, vol. 105, pp. 391–405, 2016. View at Publisher · View at Google Scholar · View at Scopus
  113. A. Tiwari and A. Pandey, “Cyanobacterial hydrogen production—a step towards clean environment,” International Journal of Hydrogen Energy, vol. 37, no. 1, pp. 139–150, 2012. View at Publisher · View at Google Scholar · View at Scopus
  114. P. Savakis and K. J. Hellingwerf, “Engineering cyanobacteria for direct biofuel production from CO2,” Current Opinion in Biotechnology, vol. 33, pp. 8–14, 2015. View at Publisher · View at Google Scholar · View at Scopus
  115. C. Leang, N. S. Malvankar, A. E. Franks, K. P. Nevin, and D. R. Lovley, “Engineering Geobacter sulfurreducens to produce a highly cohesive conductive matrix with enhanced capacity for current production,” Energy and Environmental Science, vol. 6, pp. 1901–1908, 2013. View at Publisher · View at Google Scholar · View at Scopus
  116. Z. Vajo, J. Fawcett, and W. C. Duckworth, “Recombinant DNA technology in the treatment of diabetes: insulin analogs,” Endocrine Reviews, vol. 22, no. 5, pp. 706–717, 2001. View at Publisher · View at Google Scholar · View at Scopus
  117. J. M. DeJong, Y. Liu, A. P. Bollon et al., “Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae,” Biotechnology and Bioengineering, vol. 93, no. 2, pp. 212–224, 2006. View at Publisher · View at Google Scholar · View at Scopus
  118. G. M. Walker, “Yeasts,” in Desk Encyclopedia of Microbiology, Elsevier, 2nd edition, 2009. View at Google Scholar
  119. C. Méndez, G. Weitnauer, A. Bechthold, and J. A. Salas, “Structure alteration of polyketides by recombinant DNA technology in producer organisms prospects for the generation of novel pharmaceutical drugs,” Current Pharmaceutical Biotechnology, vol. 1, no. 4, pp. 355–395, 2000. View at Publisher · View at Google Scholar · View at Scopus
  120. A. Misra, Challenges in Delivery of Therapeutic Genomics and Proteomics, Elsevier, Amsterdam, Netherlands, 2010.