Mutations in the ARAP3 Gene in Three Families with Primary Lymphedema Negative for Mutations in Known Lymphedema-Associated Genes

Table 3

Top ten models for 3D modeling of the ARAP3 structure.

Template	Seq identity	Oligo-state	QSQE	Found by	Method	Resolution	Seq similarity	Coverage	Description
3lju.1.A	22.05	Monomer	—	HHblits	X-ray	1.70 Å	0.30	0.21	ArfGAP with dual PH-domain-containing protein 1
3mdb.2.B	21.82	Monomer	—	HHblits	X-ray	2.95 Å	0.30	0.21	ArfGAP with dual PH-domain-containing protein 1
3feh.1.A	22.05	Monomer	—	HHblits	X-ray	1.90 Å	0.30	0.21	Centaurin-alpha-1
5jd0.1.A	100.00	Monomer	—	BLAST	X-ray	2.30 Å	0.60	0.13	ArfGAP with RhoGAP domain, ANK repeat, and PH-domain-containing protein 3
3mdb.1.B	21.82	Monomer	—	HHblits	X-ray	2.95 Å	0.30	0.21	ArfGAP with dual PH-domain-containing protein 1
5jcp.1.A	100.00	Monomer	—	BLAST	X-ray	2.10 Å	0.60	0.13	ArfGAP with RhoGAP domain, ANK repeat, and PH-domain-containing protein 3, linker, transforming protein RhoA
5jd0.1.A	100.00	Monomer	—	HHblits	X-ray	2.30 Å	0.60	0.13	ArfGAP with RhoGAP domain, ANK repeat, and PH-domain-containing protein 3
5jcp.1.A	100.00	Monomer	—	HHblits	X-ray	2.10 Å	0.60	0.13	ArfGAP with RhoGAP domain, ANK repeat, and PH-domain-containing protein 3, linker, transforming protein RhoA
5c5s.1.A	27.41	Monomer	—	HHblits	X-ray	2.20 Å	0.34	0.13	Unconventional myosin-IXb
5c5s.2.A	27.41	Monomer	—	HHblits	X-ray	2.20 Å	0.34	0.13	Unconventional myosin-IXb