Table of Contents Author Guidelines Submit a Manuscript
International Journal of Hepatology
Volume 2012, Article ID 282430, 8 pages
http://dx.doi.org/10.1155/2012/282430
Review Article

Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology

1Division of Cell Cycle, Regeneration and Liver Diseases, EMC Department, Institut Cochin, INSERM U1016, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
2CNRS, UMR8104, Paris, France
3Université Paris Descartes, Sorbonne Paris Cité, Paris, France

Received 21 May 2012; Accepted 10 September 2012

Academic Editor: Pascal Loyer

Copyright © 2012 Géraldine Gentric et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [32 citations]

The following is the list of published articles that have cited the current article.

  • R. M. Ricke, and J. M. van Deursen, “Aneuploidy in health, disease, and aging,” The Journal of Cell Biology, vol. 201, no. 1, pp. 11–21, 2013. View at Publisher · View at Google Scholar
  • J. M. Hernandez, A. Elahi, C. W. Clark, J. Wang, L. A. Humphries, B. Centeno, G. Bloom, B. C. Fuchs, T. Yeatman, and D. Shibata, “miR-675 Mediates Downregulation of Twist1 and Rb in AFP-Secreting Hepatocellular Carcinoma,” Annals of Surgical Oncology, vol. 20, pp. S625–S635, 2013. View at Publisher · View at Google Scholar
  • A. M. Tormos, R. Talens-Visconti, A. R. Nebreda, and J. Sastre, “p38 MAPK: A dual role in hepatocyte proliferation through reactive oxygen species,” Free Radical Research, vol. 47, no. 11, pp. 905–916, 2013. View at Publisher · View at Google Scholar
  • Yuichiro Miyaoka, and Atsushi Miyajima, “To divide or not to divide: revisiting liver regeneration,” Cell Division, vol. 8, 2013. View at Publisher · View at Google Scholar
  • S. A. Godinho, and D. Pellman, “Causes and consequences of centrosome abnormalities in cancer,” Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 369, no. 1650, pp. 20130467–20130467, 2014. View at Publisher · View at Google Scholar
  • J. A. Lopez-Dominguez, H. Khraiwesh, J. A. Gonzalez-Reyes, G. Lopez-Lluch, P. Navas, J. J. Ramsey, R. de Cabo, M. I. Buron, and J. M. Villalba, “Dietary Fat and Aging Modulate Apoptotic Signaling in Liver of Calorie-Restricted Mice,” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2014. View at Publisher · View at Google Scholar
  • R. Luisier, H. Lempiainen, N. Scherbichler, A. Braeuning, M. Geissler, V. Dubost, A. Muller, N. Scheer, S.-D. Chibout, H. Hara, F. Picard, D. Theil, P. Couttet, A. Vitobello, O. Grenet, B. Grasl-Kraupp, H. Ellinger-Ziegelbauer, J. P. Thomson, R. R. Meehan, C. R. Elcombe, C. J. Henderson, C. R. Wolf, M. Schwarz, P. Moulin, R. Terranova, and J. G. Moggs, “Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors,” Toxicological Sciences, 2014. View at Publisher · View at Google Scholar
  • Steven D. Horne, Saroj K. Chowdhury, and Henry H. Q. Heng, “Stress, genomic adaptation, and the evolutionary trade-off,” Frontiers in Genetics, vol. 5, 2014. View at Publisher · View at Google Scholar
  • Laura S. Austin, Alexis Kaushansky, and Stefan H. I. Kappe, “ Susceptibility to P lasmodium liver stage infection is altered by hepatocyte polyploidy ,” Cellular Microbiology, 2014. View at Publisher · View at Google Scholar
  • Sara Ortica, Nadine Tarantino, Nathalie Aulner, Alain Israel, and Neetu Gupta-Rossi, “The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors,” Faseb Journal, vol. 28, no. 2, pp. 603–614, 2014. View at Publisher · View at Google Scholar
  • Audrey Legendre, Marie-José Fleury, Ilaria Allora, Marie Naudot, Thibault Bricks, Sébastien Jacques, and Eric Leclerc, “Cellular Responses of Hepatocytes Induced by Hypothermia: Modulation of Cytokinesis and Drug Metabolism-Related Functions,” Therapeutic Hypothermia and Temperature Management, pp. 140225141050004, 2014. View at Publisher · View at Google Scholar
  • S Shalini, J Puccini, C H Wilson, J Finnie, L Dorstyn, and S Kumar, “Caspase-2 protects against oxidative stress in vivo,” Oncogene, 2014. View at Publisher · View at Google Scholar
  • Wei Li, Jun Long, Yasuhiro Takikawa, Kazuyuki Suzuki, and Shide Lin, “Plasma from Patients with Acute Liver Failure Dampens HepG2 Cells to Epidermal Growth Factor Induced Proliferation Response,” Hepato-Gastroenterology, vol. 61, no. 135, pp. 2021–2027, 2014. View at Publisher · View at Google Scholar
  • Adnan M. Ikhtiar, “Whole-body gamma-irradiation decelerates rat hepatocyte polyploidization,” International Journal Of Radiation Biology, vol. 91, no. 7, pp. 562–567, 2015. View at Publisher · View at Google Scholar
  • M. Sadaie, C. Dillon, M. Narita, A. R. J. Young, C. J. Cairney, L. S. Godwin, C. J. Torrance, D. C. Bennett, W. N. Keith, and M. Narita, “Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition,” Molecular Biology of the Cell, vol. 26, no. 17, pp. 2971–2985, 2015. View at Publisher · View at Google Scholar
  • Oleg B. Shevelev, Andrey E. Akulov, Anna S. Dotsenko, Galina V. Kontsevaya, Mariya A. Zolotykh, Lyudmila A. Gerlinskaya, Sergey G. Veprev, Tat'yana N. Goryachkovskaya, Natal'ya A. Zhukova, Nikolay A. Kolchanov, Sergey E. Pel'tek, and Mikhail P. Moshkin, “ Neurometabolic Effect of Altaian Fungus Ganoderma lucidum (Reishi Mushroom) in Rats Under Moderate Alcohol Consumption ,” Alcoholism: Clinical and Experimental Research, 2015. View at Publisher · View at Google Scholar
  • Hiroki Tanaka, Hidemasa Goto, Akihito Inoko, Hiroyuki Makihara, Atsushi Enomoto, Katsuhisa Horimoto, Makoto Matsuyama, Kenichi Kurita, Ichiro Izawa, and Masaki Inagaki, “Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice,” Journal Of Biological Chemistry, vol. 290, no. 21, pp. 12984–12998, 2015. View at Publisher · View at Google Scholar
  • Terry L. Orr-Weaver, “When bigger is better: the role of polyploidy in organogenesis,” Trends in Genetics, 2015. View at Publisher · View at Google Scholar
  • A. M. Tormos, R. Taléns-Visconti, A. Bonora-Centelles, S. Pérez, and J. Sastre, “Oxidative stress triggers cytokinesis failure in hepatocytes upon isolation,” Free Radical Research, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Éva Mezey, and Michael J. Brownstein, “Do circulating cells transdifferentiate and replenish stem cell pools in the brain and periphery?,” BioEssays, 2015. View at Publisher · View at Google Scholar
  • Se-Hyuk Kim, Yoon Jeon, Hyun-Soo Kim, Jin-Kwan Lee, Han Jeong Lim, Donglim Kang, Hyeseong Cho, Cheol-Keun Park, Ho Lee, and Chang-Woo Lee, “Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase,” Hepatology, vol. 63, no. 1, pp. 247–259, 2015. View at Publisher · View at Google Scholar
  • Izabela Barbosa Moraes, Camilla Manzan-Martins, Neire Moura de Gouveia, Luciana Karen Calábria, Karen Renata Nakamura Hiraki, Alberto da Silva Moraes, and Foued Salmen Espindola, “ Polyploidy Analysis and Attenuation of Oxidative Stress in Hepatic Tissue of STZ-Induced Diabetic Rats Treated with an Aqueous Extract of Vochysia rufa ,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • James A. Edwards, Phillip Bellion, Paul Beilstein, Robert Rümbeli, and Joseph Schierle, “Review of genotoxicity and rat carcinogenicity investigations with astaxanthin,” Regulatory Toxicology and Pharmacology, vol. 75, pp. 5–19, 2016. View at Publisher · View at Google Scholar
  • Noriko Takegahara, Hyunsoo Kim, Hiroki Mizuno, Asako Sakaue-Sawano, Atsushi Miyawaki, Michio Tomura, Osami Kanagawa, Masaru Ishii, and Yongwon Choi, “Involvement of Receptor Activator of Nuclear Factor-B Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts,” Journal Of Biological Chemistry, vol. 291, no. 7, pp. 3439–3454, 2016. View at Publisher · View at Google Scholar
  • Khan L. Junatas, Zbyněk Tonar, Tereza Kubíková, Václav Liška, Richard Pálek, Patrik Mik, Milena Králíčková, and Kirsti Witter, “Stereological analysis of size and density of hepatocytes in the porcine liver,” Journal of Anatomy, 2016. View at Publisher · View at Google Scholar
  • Alejandro Vazquez-Martin, Alexander E Vinogradov, Olga V Anatskaya, Alessandro Giuliani, Jekaterina Erenpreisa, Sui Huang, Kristine Salmina, Inna Inashkina, Anda Huna, and Nikolai N Nikolsky, “Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature.,” Oncotarget, vol. 7, no. 46, pp. 75235–75260, 2016. View at Publisher · View at Google Scholar
  • Marco De Santis Puzzonia, Angela Maria Cozzolino, Germana Grassi, Francesca Bisceglia, Raffaele Strippoli, Giulia Guarguaglini, Franca Citarella, Benedetto Sacchetti, Marco Tripodi, Alessandra Marchetti, and Laura Amicone, “TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure,” Plos One, vol. 11, no. 11, pp. e0167158, 2016. View at Publisher · View at Google Scholar
  • Jeeyeon M. Cha, and David M. Aronoff, “A Role for Cellular Senescence in Birth Timing,” Cell Cycle, pp. 00–00, 2017. View at Publisher · View at Google Scholar
  • H-C Chi, S-L Chen, S-L Lin, C-Y Tsai, W-Y Chuang, Y-H Lin, Y-H Huang, M-M Tsai, C-T Yeh, and K-H Lin, “Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover,” Oncogene, 2017. View at Publisher · View at Google Scholar
  • Raquel Frenedoso da Silva, Ellen Nogueira-Pangrazi, Larissa Akemi Kido, Fabio Montico, Sarah Arana, Dileep Kumar, Komal Raina, Rajesh Agarwal, and Valéria Helena Alves Cagnon, “Nintedanib antiangiogenic inhibitor effectiveness in delaying adenocarcinoma progression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP),” Journal of Biomedical Science, vol. 24, no. 1, 2017. View at Publisher · View at Google Scholar
  • Ana M. Tormos, Sergio Rius-Pérez, María Jorques, Patricia Rada, Lorena Ramirez, Ángela M. Valverde, Ángel R. Nebreda, Juan Sastre, and Raquel Taléns-Visconti, “p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging,” Plos One, vol. 12, no. 2, pp. e0171738, 2017. View at Publisher · View at Google Scholar
  • Shuyuan Zhang, Liem H. Nguyen, Kejin Zhou, Ho-Chou Tu, Alfica Sehgal, Ibrahim Nassour, Lin Li, Purva Gopal, Joshua Goodman, Amit G. Singal, Adam Yopp, Yu Zhang, Daniel J. Siegwart, and Hao Zhu, “Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration,” Gastroenterology, 2017. View at Publisher · View at Google Scholar