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International Journal of Hepatology
Volume 2012, Article ID 672986, 6 pages
http://dx.doi.org/10.1155/2012/672986
Review Article

Management of Anticoagulation for Portal Vein Thrombosis in Individuals with Cirrhosis: A Systematic Review

Liver Unit, Hôpital Saint-Luc, Centre Hospitalier de l’Université de Montréal, Montréal, QC, Canada H2X 3J4

Received 28 March 2012; Accepted 9 May 2012

Academic Editor: Averell Sherker

Copyright © 2012 Geneviève Huard and Marc Bilodeau. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. G. Delgado, S. Seijo, and I. Yepes, “Efficacy and safety of anticoagulation on individuals with cirrhosis and portal vein thrombosis,” Clinical Gastroenterology and Hepatology. In press.
  2. E. A. Tsochatzis, M. Senzolo, G. Germani, A. Gatt, and A. K. Burroughs, “Systematic review: portal vein thrombosis in cirrhosis,” Alimentary Pharmacology and Therapeutics, vol. 31, no. 3, pp. 366–374, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Tripodi and P. M. Mannucci, “The coagulopathy of chronic liver disease,” The New England Journal of Medicine, vol. 365, no. 2, pp. 147–156, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. D. C. Valla, “Thrombosis and anticoagulation in liver disease,” Hepatology, vol. 47, no. 4, pp. 1384–1393, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Plessier, P. E. Rautou, D. C. Valla et al., “Management of hepatic vascular diseases,” Journal of Hepatology, vol. 56, supplement 1, pp. S25-–S38, 2012. View at Google Scholar
  6. M. Senzolo, T. Sartori, and V. Rossetto, “Prospective evaluation of anticoagulation and transjugular intrahepatic porto-systemic shunt for the management of portal vein thrombosis in cirrhosis,” Liver International, vol. 32, pp. 919–927, 2012. View at Publisher · View at Google Scholar
  7. C. Francoz, J. Belghiti, V. Vilgrain et al., “Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation,” Gut, vol. 54, no. 5, pp. 691–697, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Tripodi, Q. M. Anstee, K. K. Sogaard et al., “Hypercoagulability in cirrhosis: causes and consequences,” Journal of Thrombosis and Haemostasis, vol. 9, no. 9, pp. 1715–1723, 2011. View at Publisher · View at Google Scholar
  9. M. J. Englesbe, J. Kubus, W. Muhammad et al., “Portal vein thrombosis and survival in patients with cirrhosis,” Liver Transplantation, vol. 16, no. 1, pp. 83–90, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Ageno, M. Galli, A. Squizzato, and F. Dentali, “Is there a role for timely diagnosis and early anticoagulant treatment of portal vein thrombosis in patients with liver cirrhosis?” Internal and Emergency Medicine, vol. 3, no. 3, pp. 195–196, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Amitrano, M. A. Guardascione, A. Menchise et al., “Safety and efficacy of anticoagulation therapy with low molecular weight heparin for portal vein thrombosis in patients with liver cirrhosis,” Journal of Clinical Gastroenterology, vol. 44, no. 6, pp. 448–451, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Villa, R. Zecchini, M. Marietta et al., “Enoxaparin prevents portal vein thrombosis (PVT) and decompensation in advanced cirrhotic individuals: final report of a prospective randomized controlled trial,” Hepatology, vol. 54, article 418a, 2011. View at Google Scholar
  13. G. Garcia-Tsao, A. J. Sanyal, N. D. Grace et al., “AASLD practice guidelines: prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis,” Hepatology, vol. 46, no. 3, pp. 922–938, 2007. View at Google Scholar
  14. L. D. DeLeve, D. C. Valla, and G. Garcia-Tsao, “Vascular disorders of the liver,” Hepatology, vol. 49, no. 5, pp. 1729–1764, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Plessier, S. Darwish-Murad, M. Hernandez-Guerra et al., “Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study,” Hepatology, vol. 51, no. 1, pp. 210–218, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. M. J. Englesbe, D. E. Schaubel, S. Cai, M. K. Guidinger, and R. M. Merion, “Portal vein thrombosis and liver transplant survival benefit,” Liver Transplantation, vol. 16, no. 8, pp. 999–1005, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Doenecke, T. Y. Tsui, C. Zuelke et al., “Pre-existent portal vein thrombosis in liver transplantation: influence of pre-operative disease severity,” Clinical Transplantation, vol. 24, no. 1, pp. 48–55, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. T. B. L. Kirkwood, “Calibration of reference thromboplastins and standardisation of the prothrombin time ratio,” Thrombosis and Haemostasis, vol. 49, no. 3, pp. 238–244, 1983. View at Google Scholar · View at Scopus
  19. M. Kovacs, A. Wong, K. MacKinnon et al., “Assessment of the validity of the INR system for individuals with liver impairment,” Journal of Thrombosis and Haemostasis, vol. 71, pp. 727–730, 1994. View at Google Scholar
  20. P. G. Northup and N. M. Intagliata, “Anticoagulation in cirrhosis patients: what don't we know?” Liver International, vol. 31, no. 1, pp. 4–6, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. L. P. Bechmann, M. Sichau, M. Wichert, G. Gerken, K. Kröger, and P. Hilgard, “Low-molecular-weight heparin in patients with advanced cirrhosis,” Liver International, vol. 31, no. 1, pp. 75–82, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Condat, F. Pessione, S. Hillaire et al., “Current outcome of portal vein thrombosis in adults: risk and benefit of anticoagulant therapy,” Gastroenterology, vol. 120, no. 2, pp. 490–497, 2001. View at Google Scholar · View at Scopus
  23. G. Kalambokis, E. Svarna, and E. V. Tsianos, “Long-term anticoagulation therapy for a cirrhotic patient with recurrent deep venous thrombosis,” Journal of Gastroenterology and Hepatology, vol. 20, no. 11, pp. 1803–1804, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Senzolo, C. Ferronato, P. Burra, and M. T. Sartori, “Anticoagulation for portal vein thrombosis in cirrhotic patients should be always considered,” Internal and Emergency Medicine, vol. 4, no. 2, pp. 161–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M Garcia-Fuster, N. Abdilla, M. J. Fabiá et al., “Venous thromboembolism and liver cirrhosis,” Revista Española de las Enfermedades del Aparato Digestivo, vol. 100, no. 5, pp. 259–262, 2008. View at Google Scholar
  26. J. S. Bajaj and J. Franco, “Endoscopic band ligation of esophageal varices in patients on anticoagulation,” Journal of Clinical Gastroenterology, vol. 42, no. 7, pp. 782–785, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Vanbiervliet, S. Giudicelli-Bornard, T. Piche et al., “Predictive factors of bleeding related to post-banding ulcer following endoscopic variceal ligation in cirrhotic patients: a case-control study,” Alimentary Pharmacology and Therapeutics, vol. 32, no. 2, pp. 225–232, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Bambha, W. R. Kim, R. Pedersen, J. P. Bida, W. K. Kremers, and P. S. Kamath, “Predictors of early re-bleeding and mortality after acute variceal haemorrhage in patients with cirrhosis,” Gut, vol. 57, no. 6, pp. 814–820, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. G. D'Amico and R. De Franchis, “Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators,” Hepatology, vol. 38, no. 3, pp. 599–612, 2003. View at Publisher · View at Google Scholar · View at Scopus