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International Journal of Hepatology
Volume 2013, Article ID 215064, 11 pages
http://dx.doi.org/10.1155/2013/215064
Review Article

Benign Hepatocellular Tumors in Children: Focal Nodular Hyperplasia and Hepatocellular Adenoma

1Department of Pediatric Radiology, Hôpital Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique Hôpitaux de Paris, 78 Rue du General Leclerc, 94278 Le Kremlin-Bicêtre, France
2Department of Pediatric Surgery, Hôpital Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique Hôpitaux de Paris, 78 Rue du General Leclerc, 94278 Le Kremlin-Bicêtre, France

Received 9 November 2012; Accepted 5 February 2013

Academic Editor: Paulette Bioulac-Sage

Copyright © 2013 Stéphanie Franchi-Abella and Sophie Branchereau. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Fukukura, O. Nakashima, A. Kusaba, M. Kage, and M. Kojiro, “Angioarchitecture and blood circulation in focal nodular hyperplasia of the liver,” Journal of Hepatology, vol. 29, no. 3, pp. 470–475, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. I. R. Wanless, C. Mawdsley, and R. Adams, “On the pathogenesis of focal nodular hyperplasia of the liver,” Hepatology, vol. 5, no. 6, pp. 1194–1200, 1985. View at Google Scholar · View at Scopus
  3. S. Rebouissou, P. Bioulac-Sage, and J. Zucman-Rossi, “Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma,” Journal of Hepatology, vol. 48, no. 1, pp. 163–170, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. B. N. Nguyen, J. F. Fléjou, B. Terris, J. Belghiti, and C. Degott, “Focal nodular hyperplasia of the liver: a comprehensive pathologic study of 305 lesions and recognition of new histologic forms,” American Journal of Surgical Pathology, vol. 23, no. 12, pp. 1441–1454, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Kumagai, T. Masuda, H. Oikawa, K. Endo, M. Endo, and T. Takano, “Focal nodular hyperplasia of the liver: direct evidence of circulatory disturbances,” Journal of Gastroenterology and Hepatology, vol. 15, no. 11, pp. 1344–1347, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Bioulac-Sage, C. Balabaud, and I. R. Wanless, “Diagnosis of focal nodular hyperplasia: not so easy,” American Journal of Surgical Pathology, vol. 25, no. 10, pp. 1322–1325, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. I. R. Wanless, S. Albrecht, J. Bilbao et al., “Multiple focal nodular hyperplasia of the liver associated with vascular malformations of various organs and neoplasia of the brain: a new syndrome,” Modern Pathology, vol. 2, no. 5, pp. 456–462, 1989. View at Google Scholar · View at Scopus
  8. F. Kondo, “Benign nodular hepatocellular lesions caused by abnormal hepatic circulation: etiological analysis and introduction of a new concept,” Journal of Gastroenterology and Hepatology, vol. 16, no. 12, pp. 1319–1328, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. A. J. Towbin, G. G. Luo, H. Yin, and J. Q. Mo, “Focal nodular hyperplasia in children, adolescents, and young adults,” Pediatric Radiology, vol. 41, no. 3, pp. 341–349, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Reymond, J. Plaschkes, A. R. Luthy, K. Leibundgut, A. Hirt, and H. P. Wagner, “Focal nodular hyperplasia of the liver in children: review of follow-up and outcome,” Journal of Pediatric Surgery, vol. 30, no. 11, pp. 1590–1593, 1995. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Lautz, N. Tantemsapya, A. Dzakovic, and R. Superina, “Focal nodular hyperplasia in children: clinical features and current management practice,” Journal of Pediatric Surgery, vol. 45, no. 9, pp. 1797–1803, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. I. N. Kochin, T. A. Miloh, R. Arnon, K. R. Iyer, F. J. Suchy, and N. Kerkar, “Benign liver masses and lesions in children: 53 cases over 12 years,” Israel Medical Association Journal, vol. 13, no. 9, pp. 542–547, 2011. View at Google Scholar
  13. C. Icher-De Bouyn, J. Leclere, G. Raimondo et al., “Hepatic focal nodular hyperplasia in children previously treated for a solid tumor: incidence, risk factors, and outcome,” Cancer, vol. 97, no. 12, pp. 3107–3113, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Gobbi, P. D. Igna, C. Messina, E. Cesca, and G. Cecchetto, “Focal nodular hyperplasia in pediatric patients with and without oncologic history,” Pediatric Blood and Cancer, vol. 55, no. 7, pp. 1420–1422, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. J. T. Stocker and K. G. Ishak, “Focal nodular hyperplasia of the liver: a study of 21 pediatric cases,” Cancer, vol. 48, no. 2, pp. 336–345, 1981. View at Google Scholar · View at Scopus
  16. J. Kang, H. J. Choi, E. Yu, I. Hwang, M. K. Young, and J. C. Hee, “A case report of fetal telangiectatic focal nodular hyperplasia,” Pediatric and Developmental Pathology, vol. 10, no. 5, pp. 416–417, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Okamura, H. Nakadate, K. Ishida et al., “Telangiectatic focal nodular hyperplasia of the liver in the perinatal period: case report,” Pediatric and Developmental Pathology, vol. 8, no. 5, pp. 581–586, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. B. M. Petrikovsky, H. L. Cohen, P. Scimeca, and E. Bellucci, “Prenatal diagnosis of focal nodular hyperplasia of the liver,” Prenatal Diagnosis, vol. 14, no. 5, pp. 406–409, 1994. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Masetti, C. Biagi, K. Kleinschmidt et al., “Focal nodular hyperplasia of the liver after intensive treatment for pediatric cancer: is hematopoietic stem cell transplantation a risk factor?” European Journal of Pediatrics, vol. 170, no. 6, pp. 807–812, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. K. J. Mortele, M. Praet, H. Van Vlierberghe, M. Kunnen, and P. R. Ros, “CT and MR imaging findings in focal nodular hyperplasia of the liver: radiologic—pathologic correlation,” American Journal of Roentgenology, vol. 175, no. 3, pp. 687–692, 2000. View at Google Scholar · View at Scopus
  21. E. A. Smith, S. Salisbury, R. Martin, and A. J. Towbin, “Incidence and etiology of new liver lesions in pediatric patients previously treated for malignancy,” American Journal of Roentgenology, vol. 199, no. 1, pp. 186–191, 2012. View at Publisher · View at Google Scholar
  22. S. Franchi-Abella, S. Branchereau, V. Lambert et al., “Complications of congenital portosystemic shunts in children: therapeutic options and outcomes,” Journal of Pediatric Gastroenterology and Nutrition, vol. 51, no. 3, pp. 322–330, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Guérin, T. Blanc, F. Gauthier, S. F. Abella, and S. Branchereau, “Congenital portosystemic vascular malformations,” Seminars in Pediatric Surgery, vol. 21, no. 3, pp. 233–244, 2012. View at Publisher · View at Google Scholar
  24. S. M. Hussain, T. Terkivatan, P. E. Zondervan et al., “Focal nodular hyperplasia: findings at state-of-the-art MR imaging, US, CT, and pathologic analysis,” Radiographics, vol. 24, no. 1, pp. 3–17, 2004. View at Google Scholar · View at Scopus
  25. J. E. Cheon, W. S. Kim, I. O. Kim, J. J. Jang, J. K. Seo, and K. M. Yeon, “Radiological features of focal nodular hyperplasia of the liver in children,” Pediatric Radiology, vol. 28, no. 11, pp. 878–883, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. G. O. Atkinson, M. Kodroff, P. J. Sones, and B. B. Gay, “Focal nodular hyperplasia of the liver in children: a report of three new cases,” Radiology, vol. 137, no. 1 I, pp. 171–174, 1980. View at Google Scholar · View at Scopus
  27. R. Somech, E. Brazowski, A. Kesller et al., “Focal nodular hyperplasia in children,” Journal of Pediatric Gastroenterology and Nutrition, vol. 32, no. 4, pp. 480–483, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Toma, A. Taccone, and C. Martinoli, “MRI of hepatic focal nodular hyperplasia: a report of two new cases in the pediatric age group,” Pediatric Radiology, vol. 20, no. 4, pp. 267–269, 1990. View at Google Scholar · View at Scopus
  29. Y. Yang, S. Fu, A. Li et al., “Management and surgical treatment for focal nodular hyperplasia in children,” Pediatric Surgery International, vol. 24, no. 6, pp. 699–703, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Blachar, M. P. Federle, J. V. Ferris et al., “Radiologists' performance in the diagnosis of liver tumors with central scars by using specific CT criteria,” Radiology, vol. 223, no. 2, pp. 532–539, 2002. View at Google Scholar · View at Scopus
  31. H. Brisse, V. Servois, B. Bouche et al., “Hepatic regenerating nodules: a mimic of recurrent cancer in children,” Pediatric Radiology, vol. 30, no. 6, pp. 386–393, 2000. View at Google Scholar · View at Scopus
  32. D. C. Sadowski, S. S. Lee, I. R. Wanless, J. K. Kelly, and E. J. Heathcote, “Progressive type of focal nodular hyperplasia characterized by multiple tumors and recurrence,” Hepatology, vol. 21, no. 4, pp. 970–975, 1995. View at Google Scholar · View at Scopus
  33. P. Bioulac-Sage, C. Balabaud, P. Bedossa et al., “Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update,” Journal of Hepatology, vol. 46, no. 3, pp. 521–527, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. V. S. Katabathina, C. O. Menias, A. K. P. Shanbhogue, J. Jagirdar, and S. R. Prasad, “Genetics and imaging of hepatocellular adenomas: 2011 update,” Radiographics, vol. 31, no. 6, pp. 1529–1543, 2011. View at Publisher · View at Google Scholar
  35. M. Ronot, S. Bahrami, J. Calderaro et al., “Hepatocellular adenomas: accuracy of magnetic resonance imaging and liver biopsy in subtype classification,” Hepatology, vol. 53, no. 4, pp. 1182–1191, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. S. M. van Aalten, M. G. J. Thomeer, T. Terkivatan et al., “Hepatocellular adenomas: correlation of MR imaging findings with pathologic subtype classification,” Radiology, vol. 261, no. 1, pp. 172–181, 2011. View at Publisher · View at Google Scholar
  37. J. Calderaro, P. Labrune, G. Morcrette et al., “Molecular characterization of hepatocellular adenomas developed in patients with glycogen storage disease type i,” Journal of Hepatology, vol. 58, no. 2, pp. 350–357, 2013. View at Publisher · View at Google Scholar
  38. M. Fabre, F. Yilmaz, and M. A. Buendia, “Hepatic tumors in childhood: experience on 245 tumors and review of literature,” Annales de Pathologie, vol. 24, no. 6, pp. 536–555, 2004. View at Google Scholar · View at Scopus
  39. B. Geramizadeh, A. Bahador, H. R. Foroutan, A. Banani, S. Nikeghbalian, and S. A. Malek-Hosseini, “Pathology of pediatric liver tumors, a single center experience from south of Iran,” Indian Journal of Pathology & Microbiology, vol. 53, no. 3, pp. 422–426, 2010. View at Google Scholar · View at Scopus
  40. D. A. Wheeler, H. A. Edmondson, and T. B. Reynolds, “Spontaneous liver cell adenoma in children,” American Journal of Clinical Pathology, vol. 85, no. 1, pp. 6–12, 1986. View at Google Scholar · View at Scopus
  41. F. I. Luks, S. Yazbeck, M. L. Brandt, A. L. Bensoussan, P. Brochu, and H. Blanchard, “Benign liver tumors in children: a 25-year experience,” Journal of Pediatric Surgery, vol. 26, no. 11, pp. 1326–1330, 1991. View at Publisher · View at Google Scholar · View at Scopus
  42. J. H. Gold, I. J. Guzman, and J. Rosai, “Benign tumors of the liver. Pathologic examination of 45 cases,” American Journal of Clinical Pathology, vol. 70, no. 1, pp. 6–17, 1978. View at Google Scholar · View at Scopus
  43. M. B. Resnick, H. P. W. Kozakewich, and A. R. Perez-Atayde, “Hepatic adenoma in the pediatric age group: clinicopathological observations and assessment of cell proliferative activity,” American Journal of Surgical Pathology, vol. 19, no. 10, pp. 1181–1190, 1995. View at Google Scholar · View at Scopus
  44. H. Laumonier, P. Bioulac-Sage, C. Laurent, J. Zucman-Rossi, C. Balabaud, and H. Trillaud, “Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification,” Hepatology, vol. 48, no. 3, pp. 808–818, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. E. M. Chung, R. Cube, R. B. Lewis, and R. M. Conran, “From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation part 1. Benign tumors,” Radiographics, vol. 30, no. 3, pp. 801–826, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. J. F. Flejou, J. Barge, Y. Menu et al., “Liver adenomatosis. An entity distinct from liver adenoma?” Gastroenterology, vol. 89, no. 5, pp. 1132–1138, 1985. View at Google Scholar · View at Scopus
  47. S. M. van Aalten, R. A. De Man, J. N. M. Ijzermans, and T. Terkivatan, “Systematic review of haemorrhage and rupture of hepatocellular adenomas,” British Journal of Surgery, vol. 99, no. 7, pp. 911–916, 2012. View at Publisher · View at Google Scholar
  48. L. Chiche, T. Dao, E. Salamé et al., “Liver adenomatosis: reappraisal, diagnosis, and surgical management—eight new cases and review of the literature,” Annals of Surgery, vol. 231, no. 1, pp. 74–81, 2000. View at Publisher · View at Google Scholar · View at Scopus
  49. A. R. Kumar, J. E. Wagner, A. D. Auerbach et al., “Fatal hemorrhage from androgen-related hepatic adenoma after hematopoietic cell transplantation,” Journal of Pediatric Hematology/Oncology, vol. 26, no. 1, pp. 16–18, 2004. View at Publisher · View at Google Scholar · View at Scopus
  50. C. D. M. Witjes, F. J. W. Ten Kate, S. M. van Aalten et al., “Hepatocellular adenoma as a risk factor for hepatocellular carcinoma in a non-cirrhotic liver: a plea against,” Gut, vol. 61, no. 11, pp. 1645–1646, 2012. View at Publisher · View at Google Scholar
  51. J. H. M. B. Stoot, E. van der Linden, O. T. Terpstra, and A. F. M. Schaapherder, “Life-saving therapy for haemorrhaging liver adenomas using selective arterial embolization,” British Journal of Surgery, vol. 94, no. 10, pp. 1249–1253, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. P. Bioulac-Sage, H. Laumonier, G. Couchy et al., “Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience,” Hepatology, vol. 50, no. 2, pp. 481–489, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. S. Dokmak, V. Paradis, V. Vilgrain et al., “A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas,” Gastroenterology, vol. 137, no. 5, pp. 1698–1705, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. D. Cassiman, L. Libbrecht, C. Verslype et al., “An adult male patient with multiple adenomas and a hepatocellular carcinoma: mild glycogen storage disease type Ia,” Journal of Hepatology, vol. 53, no. 1, pp. 213–217, 2010. View at Publisher · View at Google Scholar · View at Scopus
  55. P. S. Kishnani, T. P. Chuang, D. Bali et al., “Chromosomal and genetic alterations in human hepatocellular adenomas associated with type Ia glycogen storage disease,” Human Molecular Genetics, vol. 18, no. 24, pp. 4781–4790, 2009. View at Publisher · View at Google Scholar · View at Scopus
  56. S. M. van Aalten, J. Verheij, T. Terkivatan, R. S. Dwarkasing, R. A. De Man, and J. N. M. Ijzermans, “Validation of a liver adenoma classification system in a tertiary referral centre: implications for clinical practice,” Journal of Hepatology, vol. 55, no. 1, pp. 120–125, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. P. Labrune, P. Trioche, I. Duvaltier, P. Chevalier, and M. Odièvre, “Hepatocellular adenomas in glycogen storage disease type I and III: a series of 43 patients and review of the literature,” Journal of Pediatric Gastroenterology and Nutrition, vol. 24, no. 3, pp. 276–279, 1997. View at Publisher · View at Google Scholar · View at Scopus
  58. D. Q. Wang, L. M. Fiske, C. T. Carreras, and D. A. Weinstein, “Natural history of hepatocellular adenoma formation in glycogen storage disease type i,” Journal of Pediatrics, vol. 159, no. 3, pp. 442–446, 2011. View at Publisher · View at Google Scholar
  59. V. Fritz and L. Fajas, “Metabolism and proliferation share common regulatory pathways in cancer cells,” Oncogene, vol. 29, no. 31, pp. 4369–4377, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. J. P. Rake, G. Visser, P. Labrune, J. V. Leonard, K. Ullrich, and G. P. A. Smit, “Guidelines for management of glycogen storage disease type I—European Study on Glycogen Storage Disease Type I (ESGSD I),” European Journal of Pediatrics, vol. 161, supplement 1, pp. S112–S119, 2002. View at Google Scholar · View at Scopus
  61. L. Bianchi, “Glycogen storage disease I and hepatocellular tumours,” European Journal of Pediatrics, vol. 152, supplement 1, pp. S63–S70, 1993. View at Google Scholar · View at Scopus
  62. B. P. Alter, “Cancer in Fanconi anemia, 1927–2001,” Cancer, vol. 97, no. 2, pp. 425–440, 2003. View at Publisher · View at Google Scholar · View at Scopus
  63. V. Ozenne, V. Paradis, M.-P. Vullierme et al., “Liver tumours in patients with Fanconi anaemia: a report of three cases,” European Journal of Gastroenterology and Hepatology, vol. 20, no. 10, pp. 1036–1039, 2008. View at Publisher · View at Google Scholar
  64. I. Velazquez and B. P. Alter, “Androgens and liver tumors: Fanconi's anemia and non-Fanconi's conditions,” American Journal of Hematology, vol. 77, no. 3, pp. 257–267, 2004. View at Publisher · View at Google Scholar · View at Scopus
  65. S. Kopic, K. Eirich, B. Schuster et al., “Hepatoblastoma in a 4-year-old girl with Fanconi anaemia,” Acta Paediatrica, vol. 100, no. 5, pp. 780–783, 2011. View at Publisher · View at Google Scholar · View at Scopus
  66. B. Cassinat, P. Guardiola, S. Chevret et al., “Constitutive elevation of serum alpha-fetoprotein in Fanconi anemia,” Blood, vol. 96, no. 3, pp. 859–863, 2000. View at Google Scholar · View at Scopus
  67. C. Masserot-Lureau, N. Adoui, F. Degos et al., “Incidence of liver abnormalities in Fanconi anemia patients,” American Journal of Hematology, vol. 87, no. 5, pp. 547–549, 2012. View at Publisher · View at Google Scholar
  68. Y. Bacq, E. Jacquemin, C. Balabaud et al., “Familial liver adenomatosis associated with hepatocyte nuclear factor 1alpha inactivation,” Gastroenterology, vol. 125, no. 5, pp. 1470–1475, 2003. View at Publisher · View at Google Scholar · View at Scopus
  69. Y. Reznik, T. Dao, R. Coutant et al., “Hepatocyte nuclear factor-1α gene inactivation: cosegregation between liver adenomatosis and diabetes phenotypes in two maturity-onset diabetes of the young (MODY)3 families,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 3, pp. 1476–1480, 2004. View at Publisher · View at Google Scholar · View at Scopus
  70. K. Yamagata, H. Furuta, N. Oda et al., “Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1),” Nature, vol. 384, no. 6608, pp. 458–460, 1996. View at Publisher · View at Google Scholar · View at Scopus
  71. K. Yamagata, N. Oda, P. J. Kaisaki et al., “Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3),” Nature, vol. 384, no. 6608, pp. 455–458, 1996. View at Publisher · View at Google Scholar · View at Scopus
  72. T. Kim, T. Murakami, E. Sugihara, M. Hori, K. Wakasa, and H. Nakamura, “Hepatic nodular lesions associated with abnormal development of the portal vein,” American Journal of Roentgenology, vol. 183, no. 5, pp. 1333–1338, 2004. View at Google Scholar · View at Scopus
  73. J. L. Deneve, T. M. Pawlik, S. Cunningham et al., “Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy,” Annals of Surgical Oncology, vol. 16, no. 3, pp. 640–648, 2009. View at Publisher · View at Google Scholar · View at Scopus
  74. I. R. Marino, V. P. Scantlebury, O. Bronsther, S. Iwatsuki, and T. E. Starzl, “Total hepatectomy and liver transplant for hepatocellular adenomatosis and focal nodular hyperplasia,” Transplant International, vol. 5, supplement 1, pp. S201–S205, 1992. View at Google Scholar · View at Scopus
  75. P. J. Yunta, A. Moya, F. San-Juan et al., “A new case of hepatic adenomatosis treated with orthotopic liver transplantation,” Annales de Chirurgie, vol. 126, no. 7, pp. 672–674, 2001. View at Publisher · View at Google Scholar · View at Scopus
  76. M. G. van Vledder, S. M. van Aalten, T. Terkivatan, R. A. De Man, T. Leertouwer, and J. N. M. Ijzermans, “Safety and efficacy of radiofrequency ablation for hepatocellular adenoma,” Journal of Vascular and Interventional Radiology, vol. 22, no. 6, pp. 787–793, 2011. View at Publisher · View at Google Scholar · View at Scopus