International Journal of Hepatology

Benign Hepatocellular Tumors: A Multidisciplinary Approach


Publishing date
08 Mar 2013
Status
Published
Submission deadline
26 Oct 2012

1Department of Pathology, Bordeaux University Hospital, Bordeaux, France; Inserm U1053, Bordeaux Segalen University, Bordeaux, France

2Department of Radiology, University of Brescia, Brescia, Italy

3Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands

4The Mount Sinai Medical Center, New York, NY 10029, USA


Benign Hepatocellular Tumors: A Multidisciplinary Approach

Description

Focal nodular hyperplasia and hepatocellular adenomas are benign solitary or multiple hepatocellular tumors with different outcomes. It is, therefore, important to differentiate these two types of tumors. So far the risk of HCA bleeding and malignant transformation into hepatocellular carcinoma is based only on size. Molecular signature of HCA subtypes has permitted to better divide FNH from HCA and HCA from HCC and to identify HCA subtypes with different risks of HCC transformation. These advances have allowed to individualize HCA subtypes by immunohistochemistry on liver biopsy and to recognize the 2 major subtypes by imaging. HCA and FNH are thought to occur on the same background, but this is much too restrictive. Due to the rarity of HCA, it has not been possible to set up a consensus regarding treatment and followup of patients with benign hepatocellular tumors.

We invite investigators to contribute original research as well as review articles that will take into account the identification of FNH and HCA subtypes particularly those at risk of bleeding and malignant transformation, the circumstances and mechanisms leading to the formation of FNH and HCC, and the rational therapeutic and follow-up modalities . Potential topics include, but are not limited to:

  • Molecular biology of FNH and HCA
  • Identification of FNH and HCA by modern imaging technics
  • Identification and management of HCA (solitary and multiple) at risk of bleeding and bleeding
  • Identification and management of HCA (solitary and multiple) at risk of malignancy and with malignant transformation
  • Radiological followup of unresected FNH and HCA
  • Vascular involvement in the genesis of FNH and HCA
  • Genetic (constitutional) diseases leading to HCA
  • HCA and pregnancy

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijhep/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 153693
  • - Editorial

Benign Hepatocellular Tumors: A Multidisciplinary Approach

Paulette Bioulac-Sage | Luigi Grazioli | ... | Charissa Chang
  • Special Issue
  • - Volume 2013
  • - Article ID 253261
  • - Review Article

Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context

Paulette Bioulac-Sage | Christine Sempoux | ... | Charles Balabaud
  • Special Issue
  • - Volume 2013
  • - Article ID 268625
  • - Research Article

Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification

Charles Balabaud | Wesal R. Al-Rabih | ... | Paulette Bioulac-Sage
  • Special Issue
  • - Volume 2013
  • - Article ID 374170
  • - Review Article

MR Imaging of Hepatocellular Adenomas and Differential Diagnosis Dilemma

Luigi Grazioli | Lucio Olivetti | ... | Maria Pia Bondioni
  • Special Issue
  • - Volume 2013
  • - Article ID 215064
  • - Review Article

Benign Hepatocellular Tumors in Children: Focal Nodular Hyperplasia and Hepatocellular Adenoma

Stéphanie Franchi-Abella | Sophie Branchereau
  • Special Issue
  • - Volume 2013
  • - Article ID 398308
  • - Clinical Study

Histological and Immunohistochemical Revision of Hepatocellular Adenomas: A Learning Experience

S. Fonseca | D. Hoton | ... | C. Sempoux
  • Special Issue
  • - Volume 2013
  • - Article ID 604860
  • - Review Article

Changing Epidemiology of Hepatocellular Adenoma in the United States: Review of the Literature

Charissa Y. Chang | Juan C. Hernandez-Prera | ... | Swan N. Thung
  • Special Issue
  • - Volume 2013
  • - Article ID 417323
  • - Research Article

Value and Limits of Routine Histology Alone or Combined with Glutamine Synthetase Immunostaining in the Diagnosis of Hepatocellular Adenoma Subtypes on Surgical Specimens

Paulette Bioulac-Sage | Saïd Taouji | ... | Charles Balabaud
  • Special Issue
  • - Volume 2013
  • - Article ID 315947
  • - Review Article

Molecular Classification of Hepatocellular Adenomas

Jean Charles Nault | Jessica Zucman Rossi
  • Special Issue
  • - Volume 2012
  • - Article ID 725735
  • - Review Article

The Management of Pregnancy in Women with Hepatocellular Adenoma: A Plea for an Individualized Approach

Mirelle E. E. Bröker | Jan N. M. Ijzermans | ... | Türkan Terkivatan
International Journal of Hepatology
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