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International Journal of Hepatology
Volume 2013, Article ID 315947, 7 pages
Review Article

Molecular Classification of Hepatocellular Adenomas

1Inserm UMR-674, Génomique Fonctionnelle des Tumeurs Solides, IUH, 75010 Paris, France
2Labex Immuno-Oncology, Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, 75005 Paris, France
3Hopital Europeen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France

Received 16 October 2012; Accepted 29 December 2012

Academic Editor: Paulette Bioulac-Sage

Copyright © 2013 Jean Charles Nault and Jessica Zucman Rossi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hepatocellular adenomas (HCAs) are benign tumors developed in normal liver most frequently in women before menopause. HCAs lead to diagnostic pitfalls and several difficulties to assess the risk of malignant transformation in these young patients. Recent advances in basic knowledge have revealed a molecular classification related to risk factors, pathological features, and risk of transformation in hepatocellular carcinoma. Three major molecular pathways have been identified altered in specific HCA subgroups that are defined by either (1) inactivation of hepatocyte nuclear factor 1A (HNF1A) transcription factor, (2) activation of the WNT/β-catenin by CTNNB1 mutations, or (3) activation of the IL6/STAT3 pathway by somatic mutation of IL6ST, GNAS, or STAT3. Here, we will review the different molecular classes of HCA.