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International Journal of Hepatology
Volume 2013, Article ID 398308, 8 pages
http://dx.doi.org/10.1155/2013/398308
Clinical Study

Histological and Immunohistochemical Revision of Hepatocellular Adenomas: A Learning Experience

1Service d'Anatomie Pathologique, Cliniques Universitaires Saint-Luc, UCL, Avenue Hippocrate, 10, 1200 Brussels, Belgium
2Service de Chirurgie, Cliniques Universitaires Saint-Luc, UCL, 1200 Brussels, Belgium
3Service de Radiologie, Cliniques Universitaires Saint-Luc, UCL, 1200 Brussels, Belgium

Received 3 October 2012; Accepted 19 January 2013

Academic Editor: Charissa Chang

Copyright © 2013 S. Fonseca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. A. Edmondson, B. Henderson, and B. Benton, “Liver cell adenomas associated with use of oral contraceptives,” The New England Journal of Medicine, vol. 294, no. 9, pp. 470–472, 1976. View at Google Scholar · View at Scopus
  2. L. Giannitrapani, M. Soresi, E. La Spada, M. Cervello, N. D'Alessandro, and G. Montalto, “Sex hormones and risk of liver tumor,” Annals of the New York Academy of Sciences, vol. 1089, pp. 228–236, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. K. L. Søe, M. Soe, and C. Gluud, “Liver pathology associated with the use of anabolic-androgenic steroids,” Liver, vol. 12, no. 2, pp. 73–79, 1992. View at Google Scholar · View at Scopus
  4. S. Sakellariou, H. Al-Hussaini, A. Scalori et al., “Hepatocellular adenoma in glycogen storage disorder type I: a clinicopathological and molecular study,” Histopathology, vol. 60, no. 6 B, pp. E58–E65, 2012. View at Publisher · View at Google Scholar
  5. I. R. Wanless, J. S. Lentz, and E. A. Roberts, “Partial nodular transformation of liver in an adult with persistent ductus venosus. Review with hypothesis on pathogenesis,” Archives of Pathology and Laboratory Medicine, vol. 109, no. 5, pp. 427–432, 1985. View at Google Scholar · View at Scopus
  6. R. A. Morotti, M. Killackey, B. L. Shneider, A. Repucci, S. Emre, and S. N. Thung, “Hepatocellular carcinoma and congenital absence of the portal vein in a child receiving growth hormone therapy for Turner syndrome,” Seminars in Liver Disease, vol. 27, no. 4, pp. 427–431, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Handra-Luca, V. Paradis, V. Vilgrain et al., “Multiple mixed adenoma-focal nodular hyperplasia of the liver associated with spontaneous intrahepatic porto-systemic shunt: a new type of vascular malformation associated with the multiple focal nodular hyperplasia syndrome?” Histopathology, vol. 48, no. 3, pp. 309–311, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Koizumi, T. Yamashita, S. Dowaki et al., “Hepatobiliary and pancreatic: hepatic adenoma, focal nodular hyperplasia and congenital absence of the portal vein,” Journal of Gastroenterology and Hepatology, vol. 21, no. 3, p. 619, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. O. Bluteau, E. Jeannot, P. Bioulac-Sage et al., “Bi-allelic inactivation of TCF1 in hepatic adenomas,” Nature Genetics, vol. 32, no. 2, pp. 312–315, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. W. Chen, Y. M. Jeng, S. H. Yeh, and P. J. Chen, “p53 gene and Wnt signaling in benign neoplasms: β-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia,” Hepatology, vol. 36, no. 4, pp. 927–935, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Zucman-Rossi, E. Jeannot, J. T. Nhieu et al., “Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC,” Hepatology, vol. 43, no. 3, pp. 515–524, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Bioulac-Sage, S. Rebouissou, C. Thomas et al., “Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry,” Hepatology, vol. 46, no. 3, pp. 740–748, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Bioulac-Sage, H. Laumonier, G. Couchy et al., “Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience,” Hepatology, vol. 50, no. 2, pp. 481–489, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Rebouissou, M. Amessou, G. Couchy et al., “Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours,” Nature, vol. 457, no. 7226, pp. 200–204, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Bioulac-Sage, G. Cubel, C. Balabaud, and J. Zucman-Rossi, “Revisiting the pathology of resected benign hepatocellular nodules using new immunohistochemical markers,” Seminars in Liver Disease, vol. 31, no. 1, pp. 91–103, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. J. F. Flejou, J. Barge, and Y. Menu, “Liver adenomatosis. An entity distinct from liver adenoma?” Gastroenterology, vol. 89, no. 5, pp. 1132–1138, 1985. View at Google Scholar · View at Scopus
  17. S. Dokmak, V. Paradis, V. Vilgrain et al., “A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas,” Gastroenterology, vol. 137, no. 5, pp. 1698–1705, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. S. M. van Aalten, J. Verheij, T. Terkivatan, R. S. Dwarkasing, R. A. De Man, and J. N. M. Ijzermans, “Validation of a liver adenoma classification system in a tertiary referral centre: implications for clinical practice,” Journal of Hepatology, vol. 55, no. 1, pp. 120–125, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Bioulac-Sage, C. Balabud, and I. Wanless, “Focal nodular hyperplasia and hepatocellular adenoma,” in Tumors of the Digestive Tract, F. Bosman, F. Carneiro, R. Hruban, and N. D. Theise, Eds., pp. 198–204, World Health Organization, Lyon, France, 2010. View at Google Scholar
  20. S. P. S. Monga, “Hepatic adenomas: presumed innocent until proven to be beta-catenin mutated,” Hepatology, vol. 43, no. 3, pp. 401–404, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Bioulac-Sage, G. Cubel, and C. Balabaud, “Pathological diagnosis of hepatocellular adenoma in clinical practice,” Diagnostic Histopathology, vol. 17, no. 12, pp. 521–529, 2011. View at Publisher · View at Google Scholar
  22. M. Ronot, S. Bahrami, J. Calderaro et al., “Hepatocellular adenomas: accuracy of magnetic resonance imaging and liver biopsy in subtype classification,” Hepatology, vol. 53, no. 4, pp. 1182–1191, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. S. M. van Aalten, C. D. Witjes, R. A. de Man, J. N. Ijzermans, and T. Terkivatan, “Can a decision-making model be justified in the management of hepatocellular adenoma?” Liver International, vol. 32, pp. 28–37, 2012. View at Google Scholar
  24. S. Dardenne, C. Hubert, C. Sempoux et al., “Conservative and operative management of benign solid hepatic tumours: a successful stratified algorithm,” European Journal of Gastroenterology and Hepatology, vol. 22, no. 11, pp. 1337–1344, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. G. H. Hu, L. G. Shen, J. Yang, J. H. Mei, and Y. F. Zhu, “Insight into congenital absence of the portal vein: is it rare?” World Journal of Gastroenterology, vol. 14, no. 39, pp. 5969–5979, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Franchi-Abella, S. Branchereau, V. Lambert et al., “Complications of congenital portosystemic shunts in children: therapeutic options and outcomes,” Journal of Pediatric Gastroenterology and Nutrition, vol. 51, no. 3, pp. 322–330, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Lisovsky, A. Konstas, and J. Misdraji, “Congenital extrahepatic portosystemic shunts (abernethy malformation): a histopathologic evaluation,” The American Journal of Surgical Pathology, vol. 35, no. 9, pp. 1381–1390, 2011. View at Publisher · View at Google Scholar
  28. T. Ueda, J. Starkey, K. Mori et al., “A pictorial review of benign hepatocellular nodular lesions: comprehensive radiological assessment incorporating the concept of anomalous portal tract syndrome,” Journal of Hepato-Biliary-Pancreatic Sciences, vol. 18, no. 3, pp. 386–396, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. J. F. Hechtman, M. Raoufi, I. Fiel et al., “Hepatocellular carcinoma arising in a pigmented telangiectatic adenoma with nuclear β-catenin and glutamine synthetase positivity: case report and review of the literature,” The American Journal of Surgical Pathology, vol. 35, no. 6, pp. 927–932, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Hasan, M. Coutts, and B. Portmann, “Pigmented liver cell adenoma in two male patients,” The American Journal of Surgical Pathology, vol. 24, no. 10, pp. 1429–1432, 2000. View at Publisher · View at Google Scholar · View at Scopus