An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population

Table 6

Summary description of previous studies on the association between NOS3 haplotypes and essential hypertension.

Study first author, year of publication	Study population ethnicity, (Number of cases/Number of controls)	Evidence for association with NOS3 haplotypes	Haplotypes with statistically significant results	Direction of haplotypic genetic effect
Sandrim, 2006	Caucasians	Yes	T-b-T*	Protective
[21]	(112/113)		C-b-G*	Protective
			C-b-T*	Susceptibility
	Blacks (91/87)	Yes	T-b-T*	Protective
			C-b-G*	Protective
Sandrim, 2006	Mixed	Yes	C-b-G*	Protective
[22]	(119/102)		C-b-T*	Susceptibility
Zhao, 2006	East-Asians	No
[23]	(503/490)
Sandrim, 2006	Mixed	Yes	C-b-G*	Protective
[24]	(216/111)		C-b-T*	Susceptibility
Sandrim, 2007	Mixed	Yes	C-b-G*	Protective
[7]	(154/98)		C-b-T*	Susceptibility
Nejatizadeh, 2008 [6]	Indian (455/345)	Yes	T-a-G*	Protective
			T-a-T*	Protective
			C-a-G*	Protective
			T-b-G*	Susceptibility
Conen, 2008 [25]	Caucasian (18436)	No
Kumar, 2009 [19]	Indian (440/470)	Yes	T-a-G*	Susceptibility
			T-a-T*	Susceptibility
			C-a-G*	Susceptibility
			T-b-G*	Protective
Vasconcellos, 2010 [20]	Caucasians	Yes	C-b-G*	Protective
	(173/101)		C-a-G*	Susceptibility