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International Journal of Hypertension
Volume 2012, Article ID 189512, 8 pages
http://dx.doi.org/10.1155/2012/189512
Research Article

Renal Heme Oxygenase-1 Induction with Hemin Augments Renal Hemodynamics, Renal Autoregulation, and Excretory Function

1Department of Physiology, Hypertension and Renal Center, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL39, New Orleans, LA 70112, USA
2Laboratory of Renal and Body Fluid Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, A. Pawińskiego 5 Street, 02-106 Warsaw, Poland

Received 13 August 2011; Accepted 28 September 2011

Academic Editor: David E. Stec

Copyright © 2012 Fady T. Botros et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Heme oxygenases (HO-1; HO-2) catalyze conversion of heme to free iron, carbon monoxide, and biliverdin/bilirubin. To determine the effects of renal HO-1 induction on blood pressure and renal function, normal control rats ( ) and hemin-treated rats ( ) were studied. Renal clearance studies were performed on anesthetized rats to assess renal function; renal blood flow (RBF) was measured using a transonic flow probe placed around the left renal artery. Hemin treatment significantly induced renal HO-1. Mean arterial pressure and heart rate were not different (  mmHg versus  mmHg and versus  bpm). However, RBF was significantly higher ( versus  mL/min/g, ), and renal vascular resistance was significantly lower ( versus [mmHg/(mL/min/g)], ). Likewise, glomerular filtration rate was significantly elevated ( versus  mL/min/g, ), and urine flow and sodium excretion were also higher ( versus L/min/g, and versus mol/min/g, , resp.). The plateau of the autoregulation relationship was elevated, and renal vascular responses to acute angiotensin II infusion were attenuated in hemin-treated rats reflecting the vasodilatory effect of HO-1 induction. We conclude that renal HO-1 induction augments renal function which may contribute to the antihypertensive effects of HO-1 induction observed in hypertension models.