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International Journal of Hypertension
Volume 2012 (2012), Article ID 428950, 8 pages
http://dx.doi.org/10.1155/2012/428950
Research Article

Recombinant Expression and Characterization of Human and Murine ACE2: Species-Specific Activation of the Alternative Renin-Angiotensin-System

1APEIRON Biologics AG, Campus-Vienna-Biocenter 5, 1030 Vienna, Austria
2Graz University of Technology, Rechenbauerstraße 12, 8010 Graz, Austria
3University of Graz, Universitätsplatz 3, 8010 Graz, Austria

Received 2 September 2011; Revised 27 October 2011; Accepted 27 October 2011

Academic Editor: Anderson J. Ferreira

Copyright © 2012 Marko Poglitsch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [18 citations]

The following is the list of published articles that have cited the current article.

  • Minghao Ye, Jan Wysocki, Francisco R. Gonzalez-Pacheco, Mahmoud Salem, Karla Evora, Laura Garcia-Halpin, Marko Poglitsch, Manfred Schuster, and Daniel Batlle, “Murine Recombinant Angiotensin-Converting Enzyme 2 Effect on Angiotensin II-Dependent Hypertension and Distinctive Angiotensin-Converting Enzyme 2 Inhibitor Characteristics on Rodent and Human Angiotensin-Converting Enzyme 2,” Hypertension, vol. 60, no. 3, pp. 730–+, 2012. View at Publisher · View at Google Scholar
  • Alexandros Nikolaou, Isabelle Van den Eynde, Dirk Tourwe, Georges Vauquelin, Geza Toth, Jayapal Reddy Mallareddy, Marko Poglitsch, Jo A. Van Ginderachter, and Patrick M. L. Vanderheyden, “[H-3]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase,” European Journal Of Pharmacology, vol. 702, no. 1-3, pp. 93–102, 2013. View at Publisher · View at Google Scholar
  • Shuyu Liu, Junjun Liu, Yukie Miura, Chiaki Tanabe, Tomoji Maeda, Yasuo Terayama, Anthony J. Turner, Kun Zou, and Hiroto Komano, “Conversion of A beta 43 to A beta 40 by the Successive Action of Angiotensin-Converting Enzyme 2 and Angiotensin-Converting Enzyme,” Journal of Neuroscience Research, vol. 92, no. 9, pp. 1178–1186, 2014. View at Publisher · View at Google Scholar
  • J. J. Kovarik, M. Antlanger, O. Domenig, C. C. Kaltenecker, M. Hecking, M. Haidinger, J. Werzowa, C. Kopecky, and M. D. Saemann, “Molecular regulation of the renin-angiotensin system in haemodialysis patients,” Nephrology Dialysis Transplantation, 2014. View at Publisher · View at Google Scholar
  • Philipp K. Haber, Minghao Ye, Jan Wysocki, Christoph Maier, Syed K. Haque, and Daniel Batlle, “Angiotensin-Converting Enzyme 2-Independent Action of Presumed Angiotensin-Converting Enzyme 2 Activators Studies In Vivo, Ex Vivo, and In Vitro,” Hypertension, vol. 63, no. 4, pp. 774–782, 2014. View at Publisher · View at Google Scholar
  • Vaibhav B. Patel, Brendan Putko, Zuocheng Wang, Jiu-Chang Zhong, and Gavin Y. Oudit, “Manipulating angiotensin metabolism with angiotensin converting enzyme 2 (ACE2) in heart failure,” Drug Discovery Today: Therapeutic Strategies, 2014. View at Publisher · View at Google Scholar
  • Hai-Yan Jin, Lai-Jiang Chen, Zhen-Zhou Zhang, Ying-Le Xu, Bei Song, Ran Xu, Gavin Y Oudit, Ping-Jin Gao, Ding-Liang Zhu, and Jiu-Chang Zhong, “Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling,” Journal of Translational Medicine, vol. 13, no. 1, 2015. View at Publisher · View at Google Scholar
  • Rasna Sabharwal, Robert M. Weiss, Kathy Zimmerman, Oliver Domenig, Michael Z. Cicha, and Mark W. Chapleau, “Angiotensin-dependent autonomic dysregulation precedes dilated cardiomyopathy in a mouse model of muscular dystrophy,” Experimental Physiology, 2015. View at Publisher · View at Google Scholar
  • J. Wysocki, M. Ye, and D. Batlle, “Plasma and Kidney Angiotensin Peptides: Importance of the Aminopeptidase A/Angiotensin III Axis,” American Journal of Hypertension, 2015. View at Publisher · View at Google Scholar
  • Vaibhav B. Patel, Abhijit Takawale, Tharmarajan Ramprasath, Subhash K. Das, Ratnadeep Basu, Maria B. Grant, David A. Hall, Zamaneh Kassiri, and Gavin Y Oudit, “Antagonism of angiotensin 1–7 prevents the therapeutic effects of recombinant human ACE2,” Journal of Molecular Medicine, 2015. View at Publisher · View at Google Scholar
  • Sarah Sharp, Marko Poglitsch, Peter Zilla, Neil H. Davies, and Edward D. Sturrock, “Pharmacodynamic effects of C-domain-specific ACE inhibitors on the renin-angiotensin system in myocardial infarcted rats,” Journal Of The Renin-Angiotensin-Aldosterone System, vol. 16, no. 4, pp. 1149–1158, 2015. View at Publisher · View at Google Scholar
  • Vaibhav B. Patel, Jiu-Chang Zhong, Maria B. Grant, and Gavin Y. Oudit, “Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure,” Circulation Research, vol. 118, no. 8, pp. 1313–1326, 2016. View at Publisher · View at Google Scholar
  • Mark C. Chappell, “Reply to "Letter to the editor: Angiotensin quantification by mass spectrometry",” American Journal Of Physiology-Heart And Circulatory Physiology, vol. 310, no. 3, pp. H454–H454, 2016. View at Publisher · View at Google Scholar
  • Mark C. Chappell, “Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?,” American Journal Of Physiology-Heart And Circulatory Physiology, vol. 310, no. 2, pp. H137–H152, 2016. View at Publisher · View at Google Scholar
  • Schutte, Poglitsch, Kruger, Van Rooyen, Huisman, Mels, Malan, Botha, Lammertyn, and Gafane, “Quantification of systemic renin-angiotensin system peptides of hypertensive black and white African men established from the RAS-Fingerprint®,” JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, vol. 17, no. 4, pp. 1–7, 2016. View at Publisher · View at Google Scholar
  • Marlies Antlanger, Oliver Domenig, Johannes J Kovarik, Christopher C Kaltenecker, Chantal Kopecky, Marko Poglitsch, and Marcus D Säemann, “Molecular remodeling of the renin-angiotensin system after kidney transplantation,” Journal of the Renin-Angiotensin-Aldosterone System, vol. 18, no. 2, pp. 147032031770523, 2017. View at Publisher · View at Google Scholar
  • Marlies Antlanger, Sebastian Bernhofer, Johannes J. Kovarik, Chantal Kopecky, Christopher C. Kaltenecker, Oliver Domenig, Marko Poglitsch, and Marcus D. Säemann, “Effects of direct renin inhibition versus angiotensin II receptor blockade on angiotensin profiles in non-diabetic chronic kidney disease,” Annals of Medicine, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • Marlies Antlanger, Oliver Domenig, Johannes J. Kovarik, Christopher C. Kaltenecker, Chantal Kopecky, Marko Poglitsch, and Marcus D. Säemann, “Molecular remodeling of the renin-angiotensin system after kidney transplantation,” JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, vol. 18, no. 2, 2017. View at Publisher · View at Google Scholar