Table of Contents Author Guidelines Submit a Manuscript
International Journal of Hypertension
Volume 2012, Article ID 690785, 2 pages
http://dx.doi.org/10.1155/2012/690785
Editorial

Angiotensin-(1-7)/Angiotensin-Converting Enzyme 2/Mas Receptor Axis and Related Mechanisms

1Department of Morphology, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil
2Department of Physiology and Biophysics, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil
3Department of Physiology and Functional Genomics, College of Medicine, University of Florida, P.O. Box 100274, Gainesville, FL 32610, USA

Received 13 December 2011; Accepted 13 December 2011

Copyright © 2012 Anderson J. Ferreira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Writing Group Members on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee, “Executive summary: Heart Disease and Stroke Statistics—2011 update—a report from the American Heart Association,” Circulation, vol. 123, pp. 459–463, 2011. View at Google Scholar
  2. C. M. Ferrario, “New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin i metabolism,” Hypertension, vol. 55, no. 2, pp. 445–452, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. R. A. S. Santos, A. C. Simões e Silva, C. Maric et al., “Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 14, pp. 8258–8263, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. S. R. Tipnis, N. M. Hooper, R. Hyde, E. Karran, G. Christie, and A. J. Turner, “A human homolog of angiotensin-converting enzyme: cloning and functional expression as a captopril-insensitive carboxypeptidase,” Journal of Biological Chemistry, vol. 275, no. 43, pp. 33238–33243, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Donoghue, F. Hsieh, E. Baronas et al., “A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9,” Circulation Research, vol. 87, no. 5, pp. E1–E9, 2000. View at Google Scholar · View at Scopus
  6. A. J. Ferreira and R. A. S. Santos, “Cardiovascular actions of angiotensin-(1–7),” Brazilian Journal of Medical and Biological Research, vol. 38, no. 4, pp. 499–507, 2005. View at Google Scholar · View at Scopus
  7. P. E. Walters, T. A. Gaspari, and R. E. Widdop, “Angiotensin-(1–7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats,” Hypertension, vol. 45, no. 5, pp. 960–966, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. C. H. Castro, R. A. Santos, A. J. Ferreira, M. Bader, N. Alenina, and A. P. Almeida, “Evidence for a functional interaction of the angiotensin-(1–7) receptor Mas with AT1 and AT2 receptors in the mouse heart,” Hypertension, vol. 46, no. 4, pp. 937–942, 2005. View at Google Scholar · View at Scopus