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International Journal of Hypertension
Volume 2012, Article ID 808726, 8 pages
http://dx.doi.org/10.1155/2012/808726
Research Article

Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury

1Laboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, UFMG, 31270-901 Belo Horizonte, MG, Brazil
2Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, UFMG, 31270-901 Belo Horizonte, MG, Brazil
3Departamento de Cirurgia, Faculdade de Medicina, UFMG, 30130-100 Belo Horizonte, MG, Brazil
4Max Delbrück Center for Molecular Medicine, Berlin Buch, 13092 Berlin, Germany
5Departamento de Patologia Geral, Instituto de Ciências Biológicas, UFMG, 31270-901 Belo Horizonte, MG, Brazil
6Departamento de Microbiologia, Instituto de Ciências Biológicas, UFMG, 31270-901 Belo Horizonte, MG, Brazil
7Departamento de Pediatria, Faculdade de Medicina, UFMG, 30130-100 Belo Horizonte, MG, Brazil

Received 30 August 2011; Accepted 21 October 2011

Academic Editor: Anderson J. Ferreira

Copyright © 2012 Lívia Corrêa Barroso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Agrawal and R. Swartz, “Acute renal failure,” American Family Physician, vol. 61, no. 7, pp. 2077–2088, 2000. View at Google Scholar · View at Scopus
  2. J. G. Abuelo, “Normotensive ischemic acute renal failure,” New England Journal of Medicine, vol. 357, no. 8, pp. 797–805, 2007. View at Google Scholar · View at Scopus
  3. G. M. Chertow, E. Burdick, M. Honour, J. V. Bonventre, and D. W. Bates, “Acute kidney injury, mortality, length of stay, and costs in hospitalized patients,” Journal of the American Society of Nephrology, vol. 16, no. 11, pp. 3365–3370, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Karkar, “Cytokines and glomerulonephritis,” Saudi Journal of Kidney Diseases and Transplantation, vol. 15, no. 4, pp. 473–485, 2004. View at Google Scholar
  5. R. Thadhani, M. Pascual, and J. V. Bonventre, “Acute renal failure,” New England Journal of Medicine, vol. 334, no. 22, pp. 1448–1460, 1996. View at Google Scholar · View at Scopus
  6. H. R. Jang, G. J. Ko, B. A. Wasowska, and H. Rabb, “The interaction between ischemia-reperfusion and immune responses in the kidney,” Journal of Molecular Medicine, vol. 87, no. 9, pp. 859–864, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. I. Stroo, G. Stokman, G. J. D. Teske et al., “Chemokine expression in renal ischemia/reperfusion injury is most profound during the reparative phase,” International Immunology, vol. 22, no. 6, pp. 433–442, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Benigni, P. Cassis, and G. Remuzzi, “Angiotensin II revisited: new roles in inflammation, immunology and aging,” EMBO Molecular Medicine, vol. 2, no. 7, pp. 247–257, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. R. A. S. Santos, A. Ferreira, and A. S. E. Silva, “Angiotensins,” in Cardiovascular Hormone Systems, W.-V. V. G Co, Ed., pp. 67–100, 2008. View at Google Scholar
  10. M. Iwai and M. Horiuchi, “Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1–7)-Mas receptor axis,” Hypertension Research, vol. 32, no. 7, pp. 533–536, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. M. C. Chappell, “Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1–7)-Mas receptor axis: more than regulation of blood pressure?” Hypertension, vol. 50, no. 4, pp. 596–599, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. C. M. Ferrario, “ACE2: more of Ang-(1–7) or less Ang II?” Current Opinion in Nephrology and Hypertension, vol. 20, no. 1, p. 6, 2011. View at Publisher · View at Google Scholar
  13. R. A. S. Santos, A. J. Ferreira, and E. S. A. C. Simões, “Recent advances in the angiotensin-converting enzyme 2-angiotensin(1–7)-Mas axis,” Experimental Physiology, vol. 93, no. 5, pp. 519–527, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. D. G. Souza, V. Pinho, A. C. Soares, T. Shimizu, S. Ishii, and M. M. Teixeira, “Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment,” British Journal of Pharmacology, vol. 139, no. 4, pp. 733–740, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Zoja, D. Corna, D. Rottoli et al., “Effect of combining ACE inhibitor and statin in severe experimental nephropathy,” Kidney International, vol. 61, no. 5, pp. 1635–1645, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. S. C. Tang, J. C. K. Leung, L. Y. Y. Chan, A. A. Eddy, and K. N. Lai, “Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy,” Kidney International, vol. 73, no. 3, pp. 288–299, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. B. A. Molitoris and T. A. Sutton, “Endothelial injury and dysfunction: role in the extension phase of acute renal failure,” Kidney International, vol. 66, no. 2, pp. 496–499, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Kontogiannis and K. D. Burns, “Role of AT1 angiotensin II receptors in renal ischemic injury,” American Journal of Physiology, vol. 274, no. 1, part 2, pp. F79–F90, 1998. View at Google Scholar · View at Scopus
  19. K. D. da Silveira, K. S. P. Bosco, L. R. L. Diniz et al., “ACE2-angiotensin-(1–7)-Mas axis in renal ischaemia/reperfusion injury in rats,” Clinical Science, vol. 119, no. 9, pp. 385–394, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. S. V. B. Pinheiro, A. J. Ferreira, G. T. Kitten et al., “Genetic deletion of the angiotensin-(1–7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria,” Kidney International, vol. 75, no. 11, pp. 1184–1193, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. V. Esteban, S. Heringer-Walther, A. Sterner-Kock et al., “Angiotensin-(1–7) and the G protein-coupled receptor Mas are key players in renal inflammation,” PLoS ONE, vol. 4, no. 4, Article ID e5406, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. K. D. Silveira, F. M. Coelho, A. T. Vieira et al., “The administration of the agonist of angiotensin-(1–7), AVE0991, improved inflammation and proteinuria in experimental nephrotic syndrome,” in Proceedings of the 15th Congress of the International Pediatric Nephrology Association, vol. 25, pp. 1779–2004, Pediatric Nephrology, New York, NY, USA, 2010.
  23. F. E. Mackie, D. J. Campbell, and T. W. Meyer, “Intrarenal angiotensin and bradykinin peptide levels in the remnant kidney model of renal insufficiency,” Kidney International, vol. 59, no. 4, pp. 1458–1465, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. I. F. Benter, M. H. M. Yousif, C. Cojocel, M. Al-Maghrebi, and D. I. Diz, “Angiotensin-(1–7) prevents diabetes-induced cardiovascular dysfunction,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 292, no. 1, pp. H666–H672, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. C. X. Liu, Q. Hu, Y. Wang et al., “Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: a comparison with ACE inhibition,” Molecular Medicine, vol. 17, no. 1-2, pp. 59–69, 2011. View at Publisher · View at Google Scholar
  26. J. Zhang, N. A. Noble, W. A. Border, and Y. Huang, “Infusion of angiotensin-(1–7) reduces glomerulosclerosis through counteracting angiotensin II in experimental glomerulonephritis,” American Journal of Physiology—Renal Physiology, vol. 298, no. 3, pp. F579–F588, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Shiota, K. Yamamoto, M. Ohishi et al., “Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice,” Hypertension Research, vol. 33, no. 4, pp. 298–307, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. W. C. Burns, E. Velkoska, R. Dean, L. M. Burrell, and M. C. Thomas, “Angiotensin II mediates epithelial-to-mesenchymal transformation in tubular cells by ANG 1-7/MAS-1-dependent pathways,” American Journal of Physiology, vol. 299, no. 3, pp. F585–F593, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. J. V. Bonventre and A. Zuk, “Ischemic acute renal failure: an inflammatory disease?” Kidney International, vol. 66, no. 2, pp. 480–485, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. K. J. Kelly, W. W. Williams, R. B. Colvin et al., “Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury,” Journal of Clinical Investigation, vol. 97, no. 4, pp. 1056–1063, 1996. View at Google Scholar · View at Scopus
  31. H. T. Lee, S. W. Park, M. Kim, and V. D. D'Agati, “Acute kidney injury after hepatic ischemia and reperfusion injury in mice,” Laboratory Investigation, vol. 89, no. 2, pp. 196–208, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. K. E. de Greef, D. K. Ysebaert, S. Dauwe et al., “Anti-B7-1 blocks mononuclear cell adherence in vasa recta after ischemia,” Kidney International, vol. 60, no. 4, pp. 1415–1427, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. R. R. Molls, V. Savransky, M. Liu et al., “Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury,” American Journal of Physiology, vol. 290, no. 5, pp. F1187–F1193, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. D. G. Souza, D. C. Cara, G. D. Cassali et al., “Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat,” British Journal of Pharmacology, vol. 131, no. 8, pp. 1800–1808, 2000. View at Google Scholar · View at Scopus
  35. K. Pompermayer, D. G. Souza, G. G. Lara et al., “The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats,” Kidney International, vol. 67, no. 5, pp. 1785–1796, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. W. P. Pulskens, G. J. Teske, L. M. Butter et al., “Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury,” PLoS ONE, vol. 3, no. 10, Article ID e3596, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. J. J. Roelofs, K. M. A. Rouschop, J. C. Leemans et al., “Tissue-type plasminogen activator modulates inflammatory responses and renal function in ischemia reperfusion injury,” Journal of the American Society of Nephrology, vol. 17, no. 1, pp. 131–140, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Wu, G. Chen, K. R. Wyburn et al., “TLR4 activation mediates kidney ischemia/reperfusion injury,” Journal of Clinical Investigation, vol. 117, no. 10, pp. 2847–2859, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. L. Li, S. S. J. Sung, P. I. Lobo et al., “NKT cell activation mediates neutrophil IFN-γ production and renal eschemia-reperfusion injury,” Journal of Immunology, vol. 178, no. 9, pp. 5899–5911, 2007. View at Google Scholar · View at Scopus
  40. M. Al-Maghrebi, I. F. Benter, and D. I. Diz, “Endogenous angiotensin-(1–7) reduces cardiac ischemia-induced dysfunction in diabetic hypertensive rats,” Pharmacological Research, vol. 59, no. 4, pp. 263–268, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. R. W. Schrier, W. Wang, B. Poole, and A. Mitra, “Acute renal failure: definitions, diagnosis, pathogenesis, and therapy,” Journal of Clinical Investigation, vol. 114, no. 1, pp. 5–14, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. L. Zhou, X. Yao, and Y. Chen, “Dexamethasone pretreatment attenuates lung and kidney injury in cholestatic rats induced by hepatic ischemia/reperfusion,” Inflammation. In press. View at Publisher · View at Google Scholar
  43. D. N. Grigoryev, M. Liu, H. T. Hassoun, C. Cheadle, K. C. Barnes, and H. Rabb, “The local and systemic inflammatory transcriptome after acute kidney injury,” Journal of the American Society of Nephrology, vol. 19, no. 3, pp. 547–558, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. D. G. Souza, S. F. Coutinho, M. R. Silveira, D. C. Cara, and M. M. Teixeira, “Effects of a BLT receptor antagonist on local and remote reperfusion injuries after transient ischemia of the superior mesenteric artery in rats,” European Journal of Pharmacology, vol. 403, no. 1-2, pp. 121–128, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. K. D. Silveira, F. M. Coelho, A. T. Vieira et al., “Anti-inflammatory effects of the Activation of the angiotensin-(1–7) receptor, mas, in experimental models of arthritis,” Journal of Immunology, vol. 185, no. 9, pp. 5569–5576, 2010. View at Publisher · View at Google Scholar · View at Scopus