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International Journal of Hypertension
Volume 2013, Article ID 513047, 6 pages
Review Article

AT2 Receptor-Interacting Proteins ATIPs in the Brain

1Inserm U1016, Paris 75014, France
2CNRS UMR 8104, Paris 75014, France
3Institut Cochin, Université Paris Descartes, 22 Rue Méchain, 75014 Paris, France
4MUTABILIS S.A., 93230 Romainville, France
5J.C. Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, SC 29646, USA
6Caris Life Sciences, Phoenix, AZ 85040, USA

Received 29 November 2012; Accepted 22 December 2012

Academic Editor: Patrick Vanderheyden

Copyright © 2013 Sylvie Rodrigues-Ferreira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A complete renin-angiotensin system (RAS) is locally expressed in the brain and fulfills important functions. Angiotensin II, the major biologically active peptide of the RAS, acts via binding to two main receptor subtypes designated AT1 and AT2. The present paper focuses on AT2 receptors, which have been reported to have neuroprotective effects on stroke, degenerative diseases, and cognitive functions. Our group has identified a family of AT2 receptor interacting proteins (ATIPs) comprising three major members (ATIP1, ATIP3, and ATIP4) with different intracellular localization. Of interest, all ATIP members are expressed in brain tissues and carry a conserved domain able to interact with the AT2 receptor intracellular tail, suggesting a role in AT2-mediated brain functions. We summarize here current knowledge on the ATIP family of proteins, and we present new experimental evidence showing interaction defects between ATIP1 and two mutant forms of the AT2 receptor identified in cases of mental retardation. These studies point to a functional role of the AT2/ATIP1 axis in cognition.