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Research Article
International Journal of Hypertension
Volume 2019, Article ID 5167018, 1 page
https://doi.org/10.1155/2019/5167018
Letter to the Editor

Comment on “Pulmonary Function Tests in Hypertensive Patients Attending Zewditu Memorial Hospital, Addis Ababa, Ethiopia”

Hacettepe University Faculty of Medicine, Cardiology Department, Sıhhiye, Ankara, Turkey

Correspondence should be addressed to Yusuf Ziya Şener; rt.moc.oohay@reneszy

Received 15 December 2018; Accepted 14 March 2019; Published 4 April 2019

Academic Editor: Tomohiro Katsuya

Copyright © 2019 Yusuf Ziya Şener et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We have read with great interest the article published by Birhan et al., which was about pulmonary function tests in patients with hypertension [1]. It is worth noting that patients using beta blockers were excluded from the study and some parameters of the pulmonary function tests were significantly lower in patients with hypertension than in healthy counterparts.

It is well known that antihypertensive medications have certain effects on pulmonary functions. Beta blocking agents cause bronchoconstriction, exacerbating attacks in patients with asthma and COPD. Dry cough is a hallmark complication of treatment with ACE inhibitors. ACE degrades biologically active peptides, including bradykinin, and substance P, and ACE inhibitors lead to accumulation of these peptides. Therefore, ACE inhibitors may cause bronchoconstriction. It is also demonstrated that furosemide has preventive effects on bronchoconstriction. Hydrochlorothiazide can cause interstitial pneumonia in some patients [2]. An association between hypoxia and hypertension is documented, especially in patients with sleep apnea and obesity-hypoventilation syndrome [3]. So restrictive pattern-impaired pulmonary functions may be the cause of increased blood pressure, rather than consequence of hypertension.

To conclude, we think that it would be better if the patients’ antihypertensive medications and blood oxygen saturation levels were evaluated.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References

  1. M. M. Birhan and Y. Abebe, “Pulmonary function tests in hypertensive patients attending zewditu memorial hospital, Addis Ababa, Ethiopia,” International Journal of Hypertension, vol. 2018, Article ID 5492680, 7 pages, 2018. View at Publisher · View at Google Scholar
  2. L. L. Ben-Noun, “Drug-induced respiratory disorders: incidence, prevention and management,” Drug Safety, vol. 23, no. 2, pp. 143–164, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. J. W. Weiss, R. Tamisier, and Y. Liu, “Sympathoexcitation and arterial hypertension associated with obstructive sleep apnea and cyclic intermittent hypoxia,” Journal of Applied Physiology, vol. 119, no. 12, pp. 1449–1454, 2015. View at Publisher · View at Google Scholar · View at Scopus