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International Journal of Inflammation
Volume 2012, Article ID 879020, 10 pages
Review Article

Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies

Department of Experimental Physiology, School of Medicine, University of Athens, Athens 11527, Greece

Received 12 April 2012; Accepted 6 May 2012

Academic Editor: Petros Efthimiou

Copyright © 2012 Clio P. Mavragani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder affecting primarily young individuals. The diagnosis is primarily clinical and necessitates the exclusion of a wide range of mimicking disorders. Given the lack of solid data in regard to the underlying pathogenetic mechanisms, treatment of AOSD has been for years largely empirical. Recent advances have revealed a pivotal role of several proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-18 (IL-18) in disease pathogenesis, giving rise to the development of new targeted therapies aiming at optimal disease control.