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International Journal of Nephrology
Volume 2011, Article ID 198045, 9 pages
http://dx.doi.org/10.4061/2011/198045
Review Article

Vascular and Valvular Calcification in Chronic Peritoneal Dialysis Patients

University Department of Medicine, Queen Mary Hospital, University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong

Received 24 May 2011; Accepted 8 June 2011

Academic Editor: Domenico Russo

Copyright © 2011 Angela Yee-Moon Wang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. N. Churchill, D. W. Taylor, P. R. Keshaviah et al., “Adequacy of dialysis and nutrition in continuous peritoneal dialysis: association with clinical outcomes,” Journal of the American Society of Nephrology, vol. 7, no. 2, pp. 198–207, 1996. View at Google Scholar
  2. A. J. Collins, R. Foley, C. Herzog et al., “Excerpts from the United States Renal Data System 2007 annual data report,” American Journal of Kidney Diseases, vol. 51, no. 1, pp. S1–320, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Blacher, A. P. Guerin, B. Pannier, S. J. Marchais, and G. M. London, “Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease,” Hypertension, vol. 38, no. 4, pp. 938–942, 2001. View at Google Scholar · View at Scopus
  4. S. Okuno, E. Ishimura, K. Kitatani et al., “Presence of abdominal aortic calcification is significantly associated with all-cause and cardiovascular mortality in maintenance hemodialysis patients,” American Journal of Kidney Diseases, vol. 49, no. 3, pp. 417–425, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. G. A. Block, P. Raggi, A. Bellasi, L. Kooienga, and D. M. Spiegel, “Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients,” Kidney International, vol. 71, no. 5, pp. 438–441, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Y. M. Wang, M. Wang, J. Woo et al., “Cardiac valve calcification as an important predictor for all-cause mortality and cardiovascular mortality in long-term peritoneal dialysis patients: a prospective study,” Journal of the American Society of Nephrology, vol. 14, no. 1, pp. 159–168, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Braun, M. Oldendorf, W. Moshage, R. Heidler, E. Zeitler, and F. C. Luft, “Electron beam computed tomography in the evaluation of cardiac calcifications in chronic dialysis patients,” American Journal of Kidney Diseases, vol. 27, no. 3, pp. 394–401, 1996. View at Google Scholar · View at Scopus
  8. W. G. Goodman, J. Goldin, B. D. Kuizon et al., “Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis,” The New England Journal of Medicine, vol. 342, no. 20, pp. 1478–1483, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Eifinger, F. Wahn, U. Querfeld et al., “Coronary artery calcifications in children and young adults treated with renal replacement therapy,” Nephrology Dialysis Transplantation, vol. 15, no. 11, pp. 1892–1894, 2000. View at Google Scholar
  10. P. Raggi, A. Boulay, S. Chasan-Taber et al., “Cardiac calcification in adult hemodialysis patients: a link between end-stage renal disease and cardiovascular disease?” Journal of the American College of Cardiology, vol. 39, no. 4, pp. 695–701, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. G. M. Chertow, S. K. Burke, and P. Raggi, “Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients,” Kidney International, vol. 62, no. 1, pp. 245–252, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Oh, R. Wunsch, M. Turzer et al., “Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure,” Circulation, vol. 106, no. 1, pp. 100–105, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Nitta, T. Akiba, K. Suzuki et al., “Assessment of coronary artery calcification in hemodialysis patients using multi-detector spiral CT scan,” Hypertension Research, vol. 27, no. 8, pp. 527–533, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. G. M. London, A. P. Guérin, S. J. Marchais, F. Métivier, B. Pannier, and H. Adda, “Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality,” Nephrology Dialysis Transplantation, vol. 18, no. 9, pp. 1731–1740, 2003. View at Publisher · View at Google Scholar
  15. T. Stompór, M. Pasowicz, W. Sułowicz et al., “An association between coronary artery calcification score, lipid profile, and selected markers of chronic inflammation in ESRD patients treated with peritoneal dialysis,” American Journal of Kidney Diseases, vol. 41, no. 1, pp. 203–211, 2003. View at Publisher · View at Google Scholar
  16. A. L. Ammirati, M. A. Dalboni, M. Cendoroglo et al., “The progression and impact of vascular calcification in peritoneal dialysis patients,” Peritoneal Dialysis International, vol. 27, no. 3, pp. 340–346, 2007. View at Google Scholar · View at Scopus
  17. A. Y. M. Wang, J. Woo, M. Wang et al., “Association of inflammation and malnutrition with cardiac valve calcification in continuous ambulatory peritoneal dialysis patients,” Journal of the American Society of Nephrology, vol. 12, no. 9, pp. 1927–1936, 2001. View at Google Scholar · View at Scopus
  18. J. Huting, “Mitral valve calcification as an index of left ventricular dysfunction in patients with end-stage renal disease on peritoneal dialysis,” Chest, vol. 105, no. 2, pp. 383–388, 1994. View at Google Scholar · View at Scopus
  19. E. R. Maher, G. Young, B. Smyth-Walsh, S. Pugh, and J. R. Curtis, “Aortic and mitral valve calcification in patients with end-stage renal disease,” The Lancet, vol. 2, no. 8564, pp. 875–877, 1987. View at Google Scholar · View at Scopus
  20. S. Ribeiro, A. Ramos, A. Brandão et al., “Cardiac valve calcification in haemodialysis patients: role of calcium-phosphate metabolism,” Nephrology Dialysis Transplantation, vol. 13, no. 8, pp. 2037–2040, 1998. View at Publisher · View at Google Scholar
  21. M. P. Gruppen, J. W. Groothoff, M. Prins et al., “Cardiac disease in young adult patients with end-stage renal disease since childhood: a Dutch cohort study,” Kidney International, vol. 63, no. 3, pp. 1058–1065, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. R. M. Holden, A. S. Sanfilippo, W. M. Hopman, D. Zimmerman, J. S. Garland, and A. R. Morton, “Warfarin and aortic valve calcification in hemodialysis patients,” Journal of Nephrology, vol. 20, no. 4, pp. 417–422, 2007. View at Google Scholar · View at Scopus
  23. P. Raggi, J. Bommer, and G. M. Chertow, “Valvular calcification in hemodialysis patients randomized to calcium-based phosphorus binders or sevelamer,” The Journal of Heart Valve Disease, vol. 13, no. 1, pp. 134–141, 2004. View at Google Scholar · View at Scopus
  24. A. Bellasi, E. Ferramosca, P. Muntner et al., “Correlation of simple imaging tests and coronary artery calcium measured by computed tomography in hemodialysis patients,” Kidney International, vol. 70, no. 9, pp. 1623–1628, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Detrano, T. Hsiai, S. Wang et al., “Prognostic value of coronary calcification and angiographic stenoses in patients undergoing coronary angiography,” Journal of the American College of Cardiology, vol. 27, no. 2, pp. 285–290, 1996. View at Publisher · View at Google Scholar · View at Scopus
  26. A. A. Haydar, N. M. A. Hujairi, A. A. Covic, D. Pereira, M. Rubens, and D. J. A. Goldsmith, “Coronary artery calcification is related to coronary atherosclerosis in chronic renal disease patients: a study comparing EBCT-generated coronary artery calcium scores and coronary angiography,” Nephrology Dialysis Transplantation, vol. 19, no. 9, pp. 2307–2312, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. A. A. Haydar, A. Covic, H. Colhoun, M. Rubens, and D. J. A. Goldsmith, “Coronary artery calcification and aortic pulse wave velocity in chronic kidney disease patients,” Kidney International, vol. 65, no. 5, pp. 1790–1794, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. G. M. London, “Left ventricular alterations and end-stage renal disease,” Nephrology Dialysis Transplantation, vol. 17, no. 1, pp. 29–36, 2002. View at Google Scholar · View at Scopus
  29. M. L. Gross, H. P. Meyer, H. Ziebart et al., “Calcification of coronary intima and media: immunohistochemistry, backscatter imaging, and x-ray analysis in renal and nonrenal patients,” Clinical Journal of the American Society of Nephrology, vol. 2, no. 1, pp. 121–134, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. G. M. London, S. J. Marchais, A. P. Guérin, and F. Métivier, “Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia,” Current Opinion in Nephrology and Hypertension, vol. 14, no. 6, pp. 525–531, 2005. View at Google Scholar
  31. A. Y. M. Wang, S. S. Y. Ho, M. Wang et al., “Cardiac valvular calcification as a marker of atherosclerosis and arterial calcification in end-stage renal disease,” Archives of Internal Medicine, vol. 165, no. 3, pp. 327–332, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. G. A. Block, D. M. Spiegel, J. Ehrlich et al., “Effects of sevelamer and calcium on coronary artery calcification in patients new to hemodialysis,” Kidney International, vol. 68, no. 4, pp. 1815–1824, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. A. P. Guérin, G. M. London, S. J. Marchais, and F. Metivier, “Arterial stiffening and vascular calcifications in end-stage renal disease,” Nephrology Dialysis Transplantation, vol. 15, no. 7, pp. 1014–1021, 2000. View at Google Scholar · View at Scopus
  34. S. K. Ganesh, A. G. Stack, N. W. Levin, T. Hulbert-Shearon, and F. K. Port, “Association of elevated serum PO4, Ca × PO4 product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients,” Journal of the American Society of Nephrology, vol. 12, no. 10, pp. 2131–2138, 2001. View at Google Scholar · View at Scopus
  35. M. Noordzij, J. C. Korevaar, W. J. Bos et al., “Mineral metabolism and cardiovascular morbidity and mortality risk: peritoneal dialysis patients compared with haemodialysis patients,” Nephrology Dialysis Transplantation, vol. 21, no. 9, pp. 2513–2520, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Jono, M. D. McKee, C. E. Murry et al., “Phosphate regulation of vascular smooth muscle cell calcification,” Circulation Research, vol. 87, no. 7, pp. E10–E17, 2000. View at Google Scholar · View at Scopus
  37. T. P. Stompór, M. Pasowicz, W. Sułowicz et al., “Trends and dynamics of changes in calcification score over the 1-year observation period in patients on peritoneal dialysis,” American Journal of Kidney Diseases, vol. 44, no. 3, pp. 517–528, 2004. View at Publisher · View at Google Scholar
  38. A. Y. M. Wang, J. Woo, M. M. M. Sea, M. C. Law, S. F. Lui, and P. K. T. Li, “Hyperphosphatemia in Chinese peritoneal dialysis patients with and without residual kidney function: what are the implications?” American Journal of Kidney Diseases, vol. 43, no. 4, pp. 712–720, 2004. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Y. M. Wang, C. W. K. Lam, M. Wang, I. H. S. Chan, S. F. Lui, and J. E. Sanderson, “Is valvular calcification a part of the missing link between residual kidney function and cardiac hypertrophy in peritoneal dialysis patients?” Clinical Journal of the American Society of Nephrology, vol. 4, no. 10, pp. 1629–1636, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Mizobuchi, J. L. Finch, D. R. Martin, and E. Slatopolsky, “Differential effects of vitamin D receptor activators on vascular calcification in uremic rats,” Kidney International, vol. 72, no. 6, pp. 709–715, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. G. M. Chertow, P. Raggi, S. Chasan-Taber, J. Bommer, H. Holzer, and S. K. Burke, “Determinants of progressive vascular calcification in haemodialysis patients,” Nephrology Dialysis Transplantation, vol. 19, no. 6, pp. 1489–1496, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. G. M. London, S. J. Marchais, A. P. Guérin, P. Boutouyrie, F. Métivier, and M. C. De Vernejoul, “Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD,” Journal of the American Society of Nephrology, vol. 19, no. 9, pp. 1827–1835, 2008. View at Publisher · View at Google Scholar
  43. C. M. Otto, J. Kuusisto, D. D. Reichenbach, A. M. Gown, and K. D. O'Brien, “Characterization of the early lesion of ‘degenerative’ valvular aortic stenosis: histological and immunohistochemical studies,” Circulation, vol. 90, no. 2, pp. 844–853, 1994. View at Google Scholar · View at Scopus
  44. M. Olsson, J. Thyberg, and J. Nilsson, “Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 19, no. 5, pp. 1218–1222, 1999. View at Google Scholar · View at Scopus
  45. A. Y. M. Wang, C. W. K. Lam, M. Wang et al., “Increased circulating inflammatory proteins predict a worse prognosis with valvular calcification in end-stage renal disease: a prospective cohort study,” American Journal of Nephrology, vol. 28, no. 4, pp. 647–653, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. H. H. Jung, S. W. Kim, and H. Han, “Inflammation, mineral metabolism and progressive coronary artery calcification in patients on haemodialysis,” Nephrology Dialysis Transplantation, vol. 21, no. 7, pp. 1915–1920, 2006. View at Publisher · View at Google Scholar · View at Scopus
  47. K. Yamada, S. Fujimoto, R. Nishiura et al., “Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis,” Nephrology Dialysis Transplantation, vol. 22, no. 7, pp. 2032–2037, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. M. Ketteler, P. Bongartz, R. Westenfeld et al., “Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study,” The Lancet, vol. 361, no. 9360, pp. 827–833, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. A. Y. M. Wang, J. Woo, C. W. K. Lam et al., “Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients,” Nephrology Dialysis Transplantation, vol. 20, no. 8, pp. 1676–1685, 2005. View at Publisher · View at Google Scholar · View at Scopus
  50. C. Schäfer, A. Heiss, A. Schwarz et al., “The serum protein α2-Heremans-Schmid glycoprotein/ fetuin-A is a systemically acting inhibitor of ectopic calcification,” Journal of Clinical Investigation, vol. 112, no. 3, pp. 357–366, 2003. View at Publisher · View at Google Scholar
  51. M. M. H. Hermans, V. Brandenburg, M. Ketteler et al., “Association of serum fetuin-A levels with mortality in dialysis patients,” Kidney International, vol. 72, no. 2, pp. 202–207, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. R. C. Shroff, V. Shah, M. P. Hiorns et al., “The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not Matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis,” Nephrology Dialysis Transplantation, vol. 23, no. 10, pp. 3263–3271, 2008. View at Publisher · View at Google Scholar · View at Scopus
  53. W. C. O'Neill, M. K. Sigrist, and C. W. McIntyre, “Plasma pyrophosphate and vascular calcification in chronic kidney disease,” Nephrology Dialysis Transplantation, vol. 25, no. 1, pp. 187–191, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. G. Luo, P. Ducy, M. D. McKee et al., “Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protien,” Nature, vol. 386, no. 6620, pp. 78–81, 1997. View at Publisher · View at Google Scholar · View at Scopus
  55. S. Jono, Y. Ikari, C. Vermeer et al., “Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography,” Thrombosis and Haemostasis, vol. 91, no. 4, pp. 790–794, 2004. View at Google Scholar · View at Scopus
  56. E. C. M. Cranenburg, C. Vermeer, R. Koos et al., “The circulating inactive form of matrix Gla protein (ucMGP) as a biomarker for cardiovascular calcification,” Journal of Vascular Research, vol. 45, no. 5, pp. 427–436, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. M. M. H. Hermans, C. Vermeer, J. P. Kooman et al., “Undercarboxylated matrix GLA protein levels are decreased in dialysis patients and related to parameters of calcium-phosphate metabolism and aortic augmentation index,” Blood Purification, vol. 25, no. 5-6, pp. 395–401, 2008. View at Publisher · View at Google Scholar · View at Scopus
  58. G. Schlieper, R. Westenfeld, T. Krüger et al., “Circulating nonphosphorylated carboxylated matrix Gla protein predicts survival in ESRD,” Journal of the American Society of Nephrology, vol. 22, no. 2, pp. 387–395, 2011. View at Publisher · View at Google Scholar
  59. N. Bucay, I. Sarosi, C. R. Dunstan et al., “Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification,” Genes and Development, vol. 12, no. 9, pp. 1260–1268, 1998. View at Google Scholar · View at Scopus
  60. S. Jono, Y. Ikari, A. Shioi et al., “Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease,” Circulation, vol. 106, no. 10, pp. 1192–1194, 2002. View at Publisher · View at Google Scholar · View at Scopus
  61. K. Nitta, T. Akiba, K. Uchida et al., “Serum osteoprotegerin levels and the extent of vascular calcification in haemodialysis patients,” Nephrology Dialysis Transplantation, vol. 19, no. 7, pp. 1886–1889, 2004. View at Publisher · View at Google Scholar · View at Scopus
  62. K. Nitta, T. Akiba, K. Uchida et al., “The progression of vascular calcification and serum osteoprotegerin levels in patients on long-term hemodialysis,” American Journal of Kidney Diseases, vol. 42, no. 2, pp. 303–309, 2003. View at Publisher · View at Google Scholar · View at Scopus
  63. R. C. Shroff, R. McNair, N. Figg et al., “Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis,” Circulation, vol. 118, no. 17, pp. 1748–1757, 2008. View at Publisher · View at Google Scholar · View at Scopus
  64. R. C. Shroff, R. McNair, J. N. Skepper et al., “Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification,” Journal of the American Society of Nephrology, vol. 21, no. 1, pp. 103–112, 2010. View at Publisher · View at Google Scholar · View at Scopus
  65. M. S. Razzaque and B. Lanske, “The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis,” Journal of Endocrinology, vol. 194, no. 1, pp. 1–10, 2007. View at Publisher · View at Google Scholar · View at Scopus
  66. M. S. Razzaque, “The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis,” Nature Reviews Endocrinology, vol. 5, no. 11, pp. 611–619, 2009. View at Publisher · View at Google Scholar · View at Scopus
  67. B. Lanske and M. S. Razzaque, “Premature aging in klotho mutant mice: cause or consequence?” Ageing Research Reviews, vol. 6, no. 1, pp. 73–79, 2007. View at Publisher · View at Google Scholar · View at Scopus
  68. D. Sitara, M. S. Razzaque, R. St-Arnaud et al., “Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals,” American Journal of Pathology, vol. 169, no. 6, pp. 2161–2170, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. F. Memon, M. El-Abbadi, T. Nakatani, T. Taguchi, B. Lanske, and M. S. Razzaque, “Does Fgf23-klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism?” Kidney International, vol. 74, no. 5, pp. 566–570, 2008. View at Publisher · View at Google Scholar · View at Scopus
  70. M. C. Hu, M. Shi, J. Zhang et al., “Klotho deficiency causes vascular calcification in chronic kidney disease,” Journal of the American Society of Nephrology, vol. 22, no. 1, pp. 124–136, 2011. View at Publisher · View at Google Scholar
  71. T. Isakova, O. M. Gutierrez, Y. Chang et al., “Phosphorus binders and survival on hemodialysis,” Journal of the American Society of Nephrology, vol. 20, no. 2, pp. 388–396, 2009. View at Publisher · View at Google Scholar · View at Scopus
  72. P. Evenepoel, R. Selgas, F. Caputo et al., “Efficacy and safety of sevelamer hydrochloride and calcium acetate in patients on peritoneal dialysis,” Nephrology Dialysis Transplantation, vol. 24, no. 1, pp. 278–285, 2009. View at Publisher · View at Google Scholar · View at Scopus
  73. W. Qunibi, M. Moustafa, L. R. Muenz et al., “A 1-year randomized trial of calcium acetate versus sevelamer on progression of coronary artery calcification in hemodialysis patients with comparable lipid control: the Calcium Acetate Renagel Evaluation-2 (CARE-2),” American Journal of Kidney Diseases, vol. 51, no. 6, pp. 952–965, 2008. View at Publisher · View at Google Scholar · View at Scopus
  74. W. N. Suki, R. Zabaneh, J. L. Cangiano et al., “Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients,” Kidney International, vol. 72, no. 9, pp. 1130–1137, 2007. View at Publisher · View at Google Scholar · View at Scopus
  75. M. Ketteler and K. U. Eckardt, “KDIGO clinical practice guidelines for the diagnosis, evaluation, prevention and treatment of chronic kidney disease related mineral and bone disorders (CKD-MBD),” Kidney International, vol. 113, pp. S1–S130, 2009. View at Google Scholar
  76. L. E. Becker, N. Koleganova, G. Piecha et al., “Effect of paricalcitol and calcitriol on aortic wall remodeling in uninephrectomized ApoE knockout mice,” American Journal of Physiology, vol. 300, no. 3, pp. F772–F782, 2011. View at Publisher · View at Google Scholar
  77. M. Teng, M. Wolf, E. Lowrie, N. Ofsthun, J. M. Lazarus, and R. Thadhani, “Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy,” The New England Journal of Medicine, vol. 349, no. 5, pp. 446–456, 2003. View at Publisher · View at Google Scholar · View at Scopus
  78. N. Nagano, “Pharmacological and clinical properties of calcimimetics: calcium receptor activators that afford an innovative approach to controlling hyperparathyroidism,” Pharmacology and Therapeutics, vol. 109, no. 3, pp. 339–365, 2006. View at Publisher · View at Google Scholar · View at Scopus
  79. J. S. Lindberg, B. Culleton, G. Wong et al., “Cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism in hemodialysis and peritoneal dialysis: a randomized, double-blind, multicenter study,” Journal of the American Society of Nephrology, vol. 16, no. 3, pp. 800–807, 2005. View at Publisher · View at Google Scholar · View at Scopus
  80. S. Fishbane, W. B. Shapiro, D. B. Corry et al., “Cinacalcet HCl and concurrent low-dose vitamin D improves treatment of secondary hyperparathyroidism in dialysis patients compared with vitamin D alone: the ACHIEVE study results,” Clinical Journal of the American Society of Nephrology, vol. 3, no. 6, pp. 1718–1725, 2008. View at Publisher · View at Google Scholar · View at Scopus
  81. T. Kawata, N. Nagano, M. Obi et al., “Cinacalcet suppresses calcification of the aorta and heart in uremic rats,” Kidney International, vol. 74, no. 10, pp. 1270–1277, 2008. View at Publisher · View at Google Scholar · View at Scopus
  82. N. Koleganova, G. Piecha, E. Ritz, C. P. Schmitt, and M. L. Gross, “A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia,” Kidney International, vol. 75, no. 1, pp. 60–71, 2009. View at Publisher · View at Google Scholar · View at Scopus
  83. P. Raggi, G. M. Chertow, P. U. Torres et al., “The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis,” Nephrology Dialysis Transplantation, vol. 26, no. 4, pp. 1327–1339, 2011. View at Publisher · View at Google Scholar
  84. K. Lomashvili, P. Garg, and W. C. O'Neill, “Chemical and hormonal determinants of vascular calcification in vitro,” Kidney International, vol. 69, no. 8, pp. 1464–1470, 2006. View at Publisher · View at Google Scholar · View at Scopus
  85. T. Weinreich, J. Passlick-Deetjen, and E. Ritz, “Low dialysate calcium in continuous ambulatory peritoneal dialysis: a randomized controlled multicenter trial,” American Journal of Kidney Diseases, vol. 25, no. 3, pp. 452–460, 1995. View at Google Scholar · View at Scopus
  86. S. G. Massry, J. W. Coburn, G. M. Chertow et al., “K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease,” American Journal of Kidney Diseases, vol. 42, no. 4, supplement, pp. i-S1–i-S201, 2003. View at Google Scholar · View at Scopus
  87. S. H. Hou, J. Zhao, C. F. Ellman et al., “Calcium and phosphorus fluxes during hemodialysis with low calcium dialysate,” American Journal of Kidney Diseases, vol. 18, no. 2, pp. 217–224, 1991. View at Google Scholar · View at Scopus
  88. M. S. Demirci, M. Ozkahya, G. Asci et al., “The influence of dialysate calcium on progression of arterial stiffness in peritoneal dialysis patients,” Peritoneal Dialysis International, vol. 29, supplement 2, pp. S15–S17, 2009. View at Google Scholar · View at Scopus