Reduced Kidney Function in Tenofovir Disoproxil Fumarate Based Regimen and Associated Factors: A Hospital Based Prospective Observational Study in Ethiopian Patients
Table 2
Baseline clinical characteristics of study participants in TASH [n = 63].
Characteristics
Frequency (%)
WHO stage
Stage 1
42 (66.7)
Stage 2
3 (4.8)
Stage 3
6 (9.5)
Stage 4
12 (19)
Cotrimoxazole prophylaxis
Yes
42 (66.7)
No
21 (33.3)
Duration of HIV infection since DX
Median (IQR) 3 (0-60) months
< 3 months
37 (58.7)
≥3 months
26 (41.3)
Baseline CD4 count (cells/mm3)
Median (IQR) 241 (106-457)
< 200 CD4 count
29 (46)
≥ 200 CD4 count
34 (54)
Baseline serum creatinine (mg/dl)
Mean (±SD) 1.01 (±0.16)
< 1
18 (28.6)
≥1
45 (71.4)
Baseline eGFR (ml/min/1.73m2)
Mean (±SD) 90.8 (±16.8)
< 90
35(55.6)
≥90
28 (44.4)
History of cancer
Yes
8 (12.7)
No
55 (87.3)
Antituberculosis drugs
Yes
4 (6.3)
No
59 (93.7)
NSAIDs
Yes
6 (9.5)
No
57 (90.5)
Proton pump inhibitor
Yes
9 (14.3)
No
54 (85.7)
Chemotherapy
Yes
4 (6.3)
No
59 (93.7)
Baseline proteinuria
+1
9 (14.3)
+2
4 (6.3)
Baseline glycosuria
+1
2 (3.2)
+3
1 (1.6)
WHO, World Health Organization; DX, diagnosis; IQR, interquartile range; SD, standard deviation; NSAIDs, nonsteroidal anti-inflammatory drugs; eGFR, estimated glomerular filtration rate.
