Reduced Kidney Function in Tenofovir Disoproxil Fumarate Based Regimen and Associated Factors: A Hospital Based Prospective Observational Study in Ethiopian Patients

Table 5

Factors associated with greater than 25% fall in eGFR during the study period by univariate and multivariable logistic regression in TASH, October 2017 [n = 63].

Variable	Category	Renal dysfunction		Univariate COR (95% CI)	Multivariable AOR (95% CI)
		Yes	No
Sex	Male	7	13	1.0	1.0
	Female	9	34	0.5 (0.20, 1.64)	19.0 (0.30, 1338.12)
Age	≤ 50 years	13	43	1.0	1.0
	> 50 years	3	4	2.5 (0.49, 12.54)	64.8(1.60, 2707.70)
Body mass index (kg/m^2)	< 18.5	3	9	1.0 (0.23, 4.16)	0.08 (0.01, 3.40)
	≥18.5	13	38	1.0	1.0
Baseline CD4 count	< 200 CD4 count	13	16	8.4 (2.10, 33.80)	63.2(2.02, 1979.66)
	≥200 CD4 count	3	31	1.0	1.0
Current ART	TDF+3TC+EFV	15	41	1.0	1.0
	TDF+3TC+ATV/r	1	6	0.5 (0.50, 4.10)	0.1 (0.01, 32.90)
Cotrimoxazole prophylaxis	Yes	15	27	11.1 (1.40, 92.10)	0.91 (0.04, 22.43)
	No	1	20	1.0	1.0
History of cancer	Yes	5	3	6.7 (1.40, 32.30)	36.6 (0.50, 2699.88)
	No	11	44	1.0	1.0
Chemotherapy	Yes	2	2	3.2 (0.40, 25.00)	3.74 (0.02, 938.60)
	No	14	45	1.0
Baseline serum creatinine	< 1mg/dl	7	11	2.6 (0.80, 8.40)	0.35(0.01, 9.90)
	≥ 1mg/dl	9	36	1.0	1.0
Baseline eGFR (ml/min/1.73m^2)	< 90	5	30	1.0	1.0
	≥ 90	11	17	3.9 (1.15, 13.06)	11.6(0.23, 587.30)
Proteinuria	Yes	8	5	8.4 (2.20, 32.30)	51.33(1.80, 1448.70)
	No	8	42	1.0	1.0
Presence of glycosuria	Yes	2	1	6.6(0.60, 78.00)	53.0 (0.49, 5774.33)
	No	14	46	1.0	1.0

COR, crude odds ratio; AOR, adjusted odds ratio; CI, confidence interval; ART, antiretroviral therapy; 3TC, lamivudine; EFV, efavirenz; ATV/r, ritonavir boosted atazanavir. indicates variables that were entered in univariate logistic regression; indicates variables which were significant in multivariate logistic regression (P < 0.05).