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International Journal of Otolaryngology
Volume 2010 (2010), Article ID 640818, 1 page
Letter to the Editor

Long-Term Histologic Changes in Nasal Mucosa after Total Laryngectomy

Department of ENT, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK

Received 21 May 2010; Accepted 30 May 2010

Copyright © 2010 Chaudhary Farqan Riaz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This recently published interesting paper [1] showed statistically significant reduction (P < .005) in congestion of inferior turbinate mucosa in 2 groups of post-total laryngectomy patients over a period of time (group 1; less than 12 months, group 2; 12–36 months). I am intrigued as to which statistical test was used to calculate this and the other P values, since it was not mentioned in the study.

Also, I wonder what the authors’ and readers’ opinions are with regards to the time intervals at which biopsies were taken postoperatively. Could the other histological indices have born a statistically significant difference between the groups, where shorter time intervals are to be used (e.g., 3, 6, and 9 months)? The references cited by the authors themselves certainly do not seem to observe any standard established time frames.

It would be interesting to gauge readers’ opinion on these matters.


  1. Ç. T. Karaca, E. Gültekin, M. K. Yelken, A. A. İğdem, and M. Külekçi, “Long-term histologic changes in nasal mucosa after total laryngectomy,” International Journal of Otolaryngology, vol. 2010, Article ID 137128, 4 pages, 2010. View at Publisher · View at Google Scholar · View at PubMed