International Journal of Pediatrics

International Journal of Pediatrics / 2018 / Article

Research Article | Open Access

Volume 2018 |Article ID 3901505 | https://doi.org/10.1155/2018/3901505

Prince Adoba, Richard K. D. Ephraim, Kate Adomakowaah Kontor, Joseph-Josiah Bentsil, Patrick Adu, Maxwell Anderson, Samuel Asamoah Sakyi, Paul Nsiah, "Knowledge Level and Determinants of Neonatal Jaundice: A Cross-Sectional Study in the Effutu Municipality of Ghana", International Journal of Pediatrics, vol. 2018, Article ID 3901505, 9 pages, 2018. https://doi.org/10.1155/2018/3901505

Knowledge Level and Determinants of Neonatal Jaundice: A Cross-Sectional Study in the Effutu Municipality of Ghana

Academic Editor: F. J. Kaskel
Received13 Dec 2017
Accepted14 Feb 2018
Published01 Mar 2018

Abstract

Background. Neonatal jaundice (NNJ) is a major cause of hospital admission during the neonatal period and is associated with significant mortality. This case-control study with cross-sectional design sought to identify the possible factors associated with neonatal jaundice and assess maternal knowledge level of this condition. Methods. One hundred and fifty (150) neonates comprising 100 with clinically evident jaundice and 50 without jaundice were conveniently recruited from the Trauma and Specialist Hospital in the Effutu Municipality. Blood samples were collected for the determination of serum bilirubin, glucose-6-phosphate dehydrogenase (G6PD), status and blood group (ABO and Rhesus). Well-structured questionnaire was used to collect maternal and neonate sociodemographic and clinical history. Results. Majority (54%) of neonates developed jaundice within 1–3 days after birth with 10% having it at birth. Duration of labour and neonatal birth weight were associated with neonatal jaundice (). G6PD abnormality was found in 11 (12%) of the neonates with jaundice and ABO incompatibility was present in 18%. Neonates delivered by mothers with formal occupation and those who had prolonged duration of labour were significantly more likely to have neonatal jaundice (OR = 4.174, ; OR = 2.389, , resp.). Neonates with low birth weight were also more likely to develop neonatal jaundice (OR = 2.347, ). Only 17.3% of mothers had heard of neonatal jaundice. School was the major source of information on neonatal jaundice (34.6%). Majority of participants (mothers) did not know that NNJ can cause damage to other organs in the body (90%). Conclusion. Low neonatal birth weight and prolonged duration of labour are associated with neonatal jaundice. Mothers had inadequate knowledge of neonatal jaundice and its causes.

1. Background

Neonatal jaundice (NNJ) is a common condition worldwide occurring in up to 60% of term and 80% of preterm newborns in the first week of life [1, 2]. Newborns show clinical signs which tend to start on the head and face and then spread down the trunk and limbs as a result of high serum levels of bilirubin. Jaundice in newborns is a result of increased release of haemoglobin from breakdown of red cells due to high haemoglobin at birth, as well as due to reduced lifespan of newborn red blood cells (70–80 days) compared to that of adults (90–120 days), and reduced hepatic metabolism of bilirubin due to immature hepatocytes. Most of this newborn hyperbilirubinemia is a natural transition which resolves by the first week of life with maturing of the liver. However, hyperbilirubinemia is also the main reason for hospital admissions and readmission during the neonatal period [35]. Hyperbilirubinemia often results in kernicterus with its attendant medical, economic, and social burden on the patients, families, and societies [6, 7].

Several maternal and neonatal risk factors such as preeclampsia, G6PD deficiency, ABO incompatibility, prematurity, birth weight, intrauterine growth retardation, metabolic abnormalities, neonate’s gender, birth weight, and nutrition have been identified as risk factors for neonatal jaundice [8, 9].

From the Child Health Outpatient Department of the Korle-Bu Teaching Hospital, Ghana, no day passes without a baby coming in with neonatal jaundice [10]. In a retrospective study conducted by Onyearugha et al. [11] in Nigeria, 35% of neonates managed at a neonatal intensive care unit during a 24-month period were result of jaundice. However, there is scarcity of data on the knowledge and risk factors of neonatal jaundice in Ghana. This study therefore sought to identify the possible factors associated with neonatal jaundice and assess maternal knowledge level of this condition at Winneba in the Effutu Municipality of Ghana.

2. Methods

2.1. Study Design/Study Site

This hospital-based case-control study with cross-sectional design was conducted from November 2016 to April 2017 at Winneba in the Effutu Municipality of Ghana. The area is known for cohabitation of multiple ethnic groups. The socioeconomic classes range from peasant fisherman and street hawkers to top class civil servants and business executives. The Trauma and Specialist Hospital (TSH) was used for the study. The hospital serves as the central regional hospital providing trauma, orthopedic, and general healthcare to people in and around the region.

2.2. Study Population

A total of 150 neonates, comprising 100 with NNJ and 50 without NNJ, were conveniently recruited into the study. All neonates, either outborn or inborn, who presented to the pediatric ward of the hospital were included in the study. Babies who were above 28 days and babies whose parents did not consent to be enrolled were excluded.

2.3. Ethical Consideration

Ethical approval was obtained from the University of Cape Coast Institutional Review Board (UCCIRB) and the authorities of the hospital before starting the study. Informed written consent was also sought from the mothers and approval obtained before enrollment into the study.

2.4. Collection of Sociodemographic and Clinical Data

Sociodemographic data such as age, marital status, educational level, occupation, and residence and clinical data of neonates and mothers such as gravidity, mode of delivery, duration of labour, ANC visit, bleeding prior to labour, and parity were collected through interview and also from folders using well-structured questionnaire.

2.5. Blood Sample Collection

About 4 ml of venous blood samples were drawn from each participant and 2 ml dispensed into a dipotassium ethylenediaminetetraacetic acid (K2-EDTA) tube. The remainder was dispensed into a serum separator tube, allowed to clot, and centrifuged at 1500 rpm for 5–10 mins and the serum used for biochemical analysis.

2.6. Biochemical Tests

Serum total and direct bilirubin concentrations were estimated using Pentra C200 chemistry analyzer (34184 Montpellier Cedex 4, France). Indirect serum bilirubin level was calculated by subtracting direct bilirubin from total bilirubin.

2.7. Hematological Tests

Neonates’ blood group (ABO and Rhesus) and G6PD status were determined using standard protocols [12].

2.8. Statistical Analysis

Data were stored in Microsoft Excel and analyzed using Statistical Package for Social Sciences (SPSS) version 16.0 software. Descriptive analysis was performed and the results were expressed as numbers and percentages. Categorical variables were compared using chi-square and quantitative variables by independent -test. Multivariable logistic regression was used to determine the risk factors of neonatal jaundice. was considered statistically significant.

3. Results

Table 1 shows sociodemographic characteristics of study participants. The mean age of mothers was years and there was no difference in the ages of those with and those without NNJ. Most of the neonates with NNJ were males (52.7). Most (44%) of the mothers had SHS education with 42% having formal occupation.


ParameterTotalNNJNo NNJ value

Mother’s age (years)0.700
Mother’s age group (years)0.092
≤2014 (9.3)6 (6.0)8 (16.0)
21–3084 (56.0)61 (61.0)23 (46.0)
31–4049 (32.7)32 (32.0)17 (34.0)
>403 (2.0)1 (1.0)2 (4.0)
Sex of neonate0.817
Male79 (52.7)52 (52.0)27 (54.0)
Female71 (47.3)48 (48.0)23 (46.0)
Mother’s occupation<0.001
None39 (26.0)23 (23.0)16 (32.0)
Informal48 (32.0)23 (23.0)25 (50.0)
Formal63 (42.0)54 (54.0)9 (18.0)
Residence0.318
Town119 (79.3)77 (77.0)42 (84.0)
Village31 (20.7)23 (23.0)8 (16.0)
Marital status0.211
Single55 (36.7)34 (34.0)21 (42.0)
Married94 (62.7)66 (66.0)28 (56.0)
Divorced1 (0.7)0 (0.0)1 (2.0)
Educational level (mother)0.176
None3 (2.0)2 (2.0)1 (2.0)
Primary2 (1.3)0 (0.0)2 (4.0)
JHS46 (30.7)31 (31.0)15 (30.0)
SHS66 (44.0)48 (48.0)18 (36.0)
Tertiary33 (22.0)19 (19.0)14 (28.0)
Educational level (father)0.658
None1 (0.7)1 (1.0)0 (0.0)
Primary0 (0.0)0 (0.0)0 (0.0)
JHS15 (10.0)10 (10.0)5 (10.0)
SHS74 (49.3)52 (52.0)22 (44.0)
Tertiary60 (40.0)37 (37.0)23 (46.0)

NNJ: neonatal jaundice.

The clinical, hematological, and obstetric history of study participants stratified by jaundice status is presented on Table 2. Most of mothers of both NNJ and no NNJ were nulliparous (55% v 56%) and primigravida (45% v 50%). A significant difference was found in proportion of neonates with jaundice and those without jaundice with respect to duration of labour (). 15% of mothers with jaundiced neonates experienced vaginal bleeding prior to labour, with 20% being sickling positive. Majority 43% of mothers having neonates with jaundice had prolonged duration of labour compared to the controls (43% v 24%, ). Most of neonates with jaundice also had low birth weight compared to those without jaundice (34% v 18%, ).


ParameterTotalNNJNo NNJ value

Gravidity0.816
Primigravida70 (46.7)45 (45.0)25 (50.0)
Secundigravida43 (28.7)29 (29.0)14 (28.0)
Multigravida37 (24.7)26 (26.0)11 (22.0)
Parity0.737
Nulliparous83 (55.3)55 (55.0)28 (56.0)
Primiparous29 (19.3)18 (18.0)11 (22.0)
Multipara38 (25.3)27 (27.0)11 (22.0)
Vaginal bleeding0.637
No126 (84.0)83 (83.0)43 (43.0)
Yes24 (16.0)17 (17.0)7 (14.0)
Mode of delivery0.110
NVD94 (62.7)57 (57.0)37 (74.0)
NVDA30 (20.0)24 (24.0)6 (12.0)
CS26 (17.3)19 (19.0)7 (14.0)
Duration of labour0.023
Normal95 (63.3)57 (57.0)38 (76.0)
Prolonged55 (36.7)43 (43.0)12 (24.0)
ANC
No5 (3.3)4 (4.0)1 (2.0)
Yes145 (96.7)96 (96.0)49 (98.0)
Place of ANC0.318
Clinic24 (16.1)17 (17.0)7 (14.3)
Hospital121 (81.2)79 (79.0)42 (85.7)
Suckling0.305
No13 (8.7)7 (7.0)6 (12.0)
Yes137 (91.3)93 (93.0)44 (88.0)
Traditional medicine0.134
No129 (86.0)89 (89.0)40 (80.0)
Yes21 (14.0)11 (11.0)10 (20.0)
Mother’s sickling status0.553
Negative122 (81.3)80 (80.0)42 (84.0)
Positive28 (18.7)20 (20.0)8 (16.0)
Mother’s G6PD status0.115
Normal126 (84.0)80 (80.0)46 (92.0)
PD12 (8.0)11 (11.0)1 (2.0)
FD12 (8.0)9 (9.0)3 (6.0)
Birth weight0.041
Low43 (28.7)34 (34.0)9 (18.0)
Normal107 (71.3)66 (66.0)41 (82.0)
Birth weight0.210
Gestation0.226

NVD: normal vaginal delivery; NVDA: normal vaginal delivery with aid; CS: caesarian section; ANC: antenatal care; PD: partial enzyme defect; FD: full enzyme defect.

Majority (54%) of neonates developed jaundice within 1–3 days after birth with 10% having it at birth (Table 3). Mean DB was significantly higher among males than females ( versus , ). G6PD abnormality was found in 11 (12%) of the neonates with jaundice and ABO blood group incompatibility was present in 18%. No significant difference was found between birth weight, TB, and IDB of male and female neonates with jaundice () (Table 3).


ParameterTotalMalesFemales value

Mother’s age (years)0.271
Mode of delivery0.749
NVD57 (57.0)28 (53.8)29 (60.4)
NVDA24 (24.0)14 (26.9)10 (20.8)
CS19 (19.0)10 (19.2)9 (18.8)
Duration of labour0.507
Normal57 (57.0)28 (53.8)29 (60.4)
Prolonged43 (43.0)24 (46.2)19 (39.6)
Mother’s sickling status0.484
Negative80 (80.0)43 (82.7)37 (77.1)
Positive20 (20.0)9 (17.3)11 (22.9)
Mother’s G6PD status0.456
Normal80 (80.0)44 (84.6)36 (75.0)
PD11 (11.0)4 (7.7)7 (14.6)
FD9 (9.0)4 (7.7)5 (10.4)
Begin of condition0.048
At birth10 (10.0)7 (13.5)3 (6.2)
1–3 days54 (54.0)22 (42.3)32 (66.7)
≥4 days36 (36.0)23 (44.2)13 (27.1)
Neonate’s G6PD status0.511
Normal88 (88.0)47 (90.4)41 (85.4)
PD1 (1.0)0 (0.0)1 (2.1)
FD11 (11.0)5 (9.6)6 (12.5)
Blood group incompatibility0.169
No82 (82.0)40 (76.9)42 (87.5)
Yes18 (18.0)12 (23.1)6 (12.5)
TB (µmol/L)0.058
Normal18 (18.0)13 (25.0)5 (10.4)
High82 (82.0)39 (75.0)43 (89.6)
DB (µmol/L)0.057
Normal59 (59.0)26 (50.0)33 (68.8)
High41 (41.0)26 (50.0)15 (31.2)
IDB (µmol/L)-
High100 (100.0)52 (100.0)48 (100.0)
Birth weight0.774
Low34 (34.0)17 (32.7)17 (35.4)
Normal66 (66.0)35 (67.3)31 (64.6)
Mean birth weight0.705
Gestation0.508
TB (µmol/L)0.390
DB (µmol/L)0.019
IDB (µmol/L)0.552

TB: total bilirubin; DB: direct bilirubin; IDB: indirect bilirubin.

Table 4 presents a correlation of demographic and clinical characteristics of study participants. Maternal age had a positive correlation with gravidity and parity. Gestational age negatively correlated with total bilirubin (, ), direct bilirubin (, ), indirect bilirubin (, ), and birth weight (, ). Total bilirubin had a positive correlation with direct and indirect bilirubin, but a negative correlation with birth weight (, ). Indirect bilirubin also negatively correlated with birth weight (, ).


AgeGestationGravidityParityTBDBIDBBWt

Age
r10.1280.7150.7260.1190.0990.1170.096
P0.206<0.001<0.0010.2370.3260.2470.342
Gestation
r10.0650.013
P0.5220.9020.0020.0170.003<0.001
Gravidity
r10.8000.0360.0490.070
P<0.0010.7230.7310.6270.490
Parity
r10.0690.084
P0.4960.5620.4040.810
TB
r10.3920.990
P<0.001<0.0010.002
DB
r10.289
P0.0040.268
IDB
r1
P0.020
BWt
r1
P

BWt: birth weight.

Neonates delivered by mothers with formal occupation and those who had prolonged duration of labour were significantly more likely to have neonatal jaundice (OR = 4.174, ; OR = 2.389, ). Neonates with low birth weight also were significantly more likely to develop neonatal jaundice (OR = 2.347, ) (Table 5).


ParameterOR (95% CI) value

Age group (years)
≤201.500 (0.109–20.675)0.762
21–305.304 (0.459–61.339)0.182
31–403.765 (0.318–44.574)0.293
>40Reference
Sex
Male0.923 (0.467–1.827)0.817
FemaleReference
Occupation
NoneReference
Informal0.640 (0.273–1.502)0.305
Formal4.174 (1.612–10.807)0.003
Gravidity
PrimigravidaReference
Secundigravida1.151 (0.515–2.571)0.732
Multigravida1.313 (0.557–3.097)0.534
Parity
NulliparousReference
Primiparous0.833 (0.346–2.003)0.683
Multipara1.250 (0.542–2.882)0.601
Vaginal bleeding
NoReference
Yes1.258 (0.485–3.267)0.637
Mode of delivery
NVDReference
NVDA2.596 (0.969–6.957)0.058
CS1.762 (0.674–4.603)0.248
Duration of labour
NormalReference
Prolonged2.389 (1.117–5.109)0.025
ANC
No2.042 (0.222–18.764)0.528
YesReference
Suckling
NoReference
Yes1.812 (0.575–5.710)0.310
Traditional medicine
NoReference
Yes0.494 (0.194–1.258)0.139
Mother’s sickling status
NegativeReference
Positive1.313 (0.533–3.231)0.554
Mother’s G6PD status
NormalReference
PD6.325 (0.791–50.577)0.082
FD1.725 (0.444–6.694)0.431
Birth weight
Low2.347 (1.022–5.391)0.044
NormalReference

Only 17.3% of mothers had heard of neonatal jaundice: 20% of those with babies with NNJ and 12% of those without NNJ. School was the major source of information on neonatal jaundice (34.6%) followed by friends (15.4%), with TV being the least source (7.7%). Majority did not know that NNJ can cause damage to other organs in the body (90%), can be prevented (92.7%), or can be treated (85.3%) (Table 6).


ParameterTotalNNJNo NNJ

Heard of NNJ
No124 (82.7)80 (80.0)44 (88.0)
Yes26 (17.3)20 (20.0)6 (12.0)
Source
Friends11 (42.3)10 (50.0)1 (16.7)
Health facility4 (15.4)4 (20.0)0 (0.0)
School9 (34.6)4 (20.0)5 (83.3)
TV2 (7.7)2 (10.0)0 (0.0)
Can NNJ cause damage?
Do not know135 (90.0)89 (89.0)46 (92.0)
No5 (3.3)5 (5.0)0 (0.0)
Yes10 (6.7)6 (6.0)4 (8.0)
Can NNJ be prevented?
Do not know139 (92.7)93 (93.0)46 (92.0)
No5 (3.3)4 (4.0)1 (2.0)
Yes6 (4.0)3 (3.0)3 (6.0)
Can NNJ be treated?
Do not know128 (85.3)83 (83.0)45 (90.0)
No0 (0.0)0 (0.0)0 (0.0)
Yes22 (14.7)17 (17.0)5 (10.0)

4. Discussion

This study sought to identify the possible factors associated with neonatal jaundice and assess maternal knowledge level of this condition at Winneba in the Effutu Municipality of Ghana.

Majority (54%) of neonates developed jaundice within 1–3 days after birth with 10% having it at birth. Birth weight and prolonged duration of labour were associated with neonatal jaundice; mothers had inadequate knowledge of neonatal jaundice.

Most of neonates with jaundice had low birth weight compared to those without jaundice. This is comparable to the findings of a study conducted in Southern Nigeria [13]. Our study also confirmed an earlier observation by Menon and Amanullah [14] and Devi and Vijaykumar [15] which associated neonatal jaundice with low neonatal birth weight in India. This is further buttressed by the finding of neonates with low birth weight being more likely to develop neonatal jaundice in the logistic regression.

Duration of labour was associated with neonatal jaundice, with majority of mothers with jaundiced neonates having prolonged duration of labour compared to the controls. This is similar to the finding of prolonged labour being strongly associated with jaundice in a community-based trial conducted by Scrafford et al. in Nepal [16]. This is most likely due to the clinical relationship between longer duration of labour and cephalohematoma, a known risk factor for severe hyperbilirubinemia [17, 18]. This finding is also supported by the observation of mothers with prolonged duration of labour being more likely to have neonates developing jaundice in our study.

A study conducted in Asia documented ABO incompatibility and G6PD deficiency as the leading causes of neonatal jaundice [19]. G6PD abnormality was found in 11 (12%) of the neonates with jaundice lower than the 25.5% found by Najib et al. [9] in South Iran, but higher than the 4.2% observed by Huang et al. [8] in a case-control study carried out in Taiwan.

ABO incompatibility has been significantly associated with neonatal hyperbilirubinemia [20]. The 18% ABO blood group incompatibility present among neonates with jaundice in our study is higher than the 5.9% reported by Najib et al. [9] in a prospective longitudinal study conducted in Iran, but lower than the 35.5% recorded by Menon and Amanullah [14] in a case-control study conducted in India.

Preterm neonates who have concurrent illnesses and physiologic derangements are more vulnerable to bilirubin neurotoxicity and have been recognized and studied in clinical trials. Bilirubin-related neurotoxicity can result in neonatal death or multisystem acute manifestations and long-term impairments, including irreversible athetoid cerebral palsy (CP) and speech, visuomotor, auditory, and other sensory-processing disabilities [2123]. Gestational age negatively correlated with total bilirubin, direct bilirubin, indirect bilirubin, and birth weight. This is in line with the finding of significant hyperbilirubinemia among preterm neonates compared to termed neonates in a longitudinal study conducted by Sarici et al. [6] in Turkey. Preterm newborns are prone to developing jaundice due to immaturity of their bilirubin conjugating system, higher rate of haemolysis, increased enterohepatic circulation, and decreased caloric intake [24].

Neonates delivered by mothers with formal occupation were significantly more likely to have neonatal jaundice in this study. This is consistent with the findings of a community-based study conducted in Nigeria by Olusanya et al. [25] in which neonates born to mothers with full time employment were more likely to have jaundice.

Only 17.3% of mothers in this study had heard of neonatal jaundice. This is far lower than the finding of 96% of mothers being aware of neonatal jaundice in a cross-sectional study carried out among expectant mothers in Abia State, southeast Nigeria [11]. In their study, most of the participants got their information from health workers (50%) and friends (26%). However, in our study, school was the major source of information on neonatal jaundice (34.6%) followed by friends, with TV being the least source.

Goodman et al. [26] also found a high level of awareness among mothers (75%) with 74.1% having knowledge of the causes of neonatal jaundice. This is contrary to the finding of majority of our participants (90%) not knowing the cause of neonatal jaundice. Mothers' low knowledge of neonatal jaundice and its causes places them at a very grave risk of ignoring possibly avoidable predisposing factors and even signs that demand immediate management of jaundice in newborns making them develop jaundice and often being presented to healthcare facilities when irreversible neurotoxicity and brain damage might have occurred [26].

Our inability to assess the serum bilirubin, blood group, and G6PD status of neonates with jaundice and other genetic causes of neonatal jaundice (e.g., polymorphisms of UDP-glucuronosyltransferase 1A1 gene) served as a limitation to this study. Also, the study is limited by the small number of neonates without jaundice used.

5. Conclusion

Low neonatal birth weight and prolonged duration of labour are associated with neonatal jaundice. Mothers had inadequate knowledge of neonatal jaundice and its causes. Education on the condition and its causes should be intensified especially by healthcare workers during regular antenatal visits. Other causes of neonatal jaundice need to be examined in the routine management of neonates.

Abbreviations

NNJ:Neonatal jaundice
G6PD:Glucose-6-phosphate dehydrogenase.

Data Availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Ethical Approval

Ethical approval was obtained from the University of Cape Coast Institutional Review Board (UCCIRB) and the authorities of the hospital before starting the study.

Informed written consent was sought from the mothers, and approval for publication of research findings including participants’ details was obtained before enrollment into the study.

Conflicts of Interest

The authors declare that there are no conflicts of interest.

Authors’ Contributions

Prince Adoba, Richard K. D. Ephraim, Patrick Adu, and Joseph-Josiah Bentsil conceived the study and participated in its design and coordination. Prince Adoba, Joseph-Josiah Bentsil, Maxwell Anderson, and Kate Adomakowaah Kontor were involved in the recruitment of participants, data collection, and analysis of samples. Prince Adoba, Richard K. D. Ephraim, Patrick Adu, and Samuel Asamoah Sakyi drafted the manuscript. Samuel Asamoah Sakyi, Maxwell Anderson, and Paul Nsiah provided analytic and statistical support. All authors read and approved the final manuscript.

Acknowledgments

The authors wish to thank all the participants who agreed to be enrolled in the study and the management and laboratory staff of the Trauma and Specialist Hospital, Winneba, for their support.

References

  1. K. M. Haque and M. Rahman, “An unusual case of ABO-haemolytic disease of the newborn,” Bangladesh Medical Research Council Bulletin, vol. 26, no. 2, pp. 61–64, 2000. View at: Google Scholar
  2. T. M. Slusher, I. A. Angyo, F. Bode-Thomas et al., “Transcutaneous bilirubin measurements and serum total bilirubin levels in indigenous African infants,” Pediatrics, vol. 113, no. 6 I, pp. 1636–1641, 2004. View at: Publisher Site | Google Scholar
  3. A. M. Geiger, D. B. Petitti, and J. F. Yao, “Rehospitalisation for neonatal jaundice: risk factors and outcomes.,” Paediatric and Perinatal Epidemiology, vol. 15, no. 4, pp. 352–358, 2001. View at: Publisher Site | Google Scholar
  4. M. J. Maisels and E. Kring, “Length of stay, jaundice, and hospital readmission,” Pediatrics, vol. 101, no. 6, pp. 995–998, 1998. View at: Publisher Site | Google Scholar
  5. D. S. Seidman, D. K. Stevenson, Z. Ergaz, and R. Gale, “Hospital readmission due to neonatal hyperbilirubinemia,” Pediatrics, vol. 96, no. 4 I, pp. 727–729, 1995. View at: Google Scholar
  6. S. Ü. Sarici, M. A. Serdar, A. Korkmaz et al., “Incidence, course, and prediction of hyperbilirubinemia in near-term and term new-borns,” Pediatrics, vol. 113, pp. 775–780, 2004. View at: Publisher Site | Google Scholar
  7. M. Wang, T. Hays, D. R. Ambruso, C. C. Silliman, and W. C. Dickey, “Hemolytic disease of the newborn caused by a high titer anti-group B IgG from a group A mother [1],” Pediatric Blood & Cancer, vol. 45, no. 6, pp. 861-862, 2005. View at: Publisher Site | Google Scholar
  8. M.-J. Huang, K.-E. Kua, H.-C. Teng, K.-S. Tang, H.-W. Weng, and C.-S. Huang, “Risk factors for severe hyperbilirubinemia in neonates,” Pediatric Research, vol. 56, no. 5, pp. 682–689, 2004. View at: Publisher Site | Google Scholar
  9. K. S. Najib, F. Saki, F. Hemmati, and S. Inaloo, “Incidence, risk factors and causes of severe neonatal hyperbilirubinemia in South of Iran (Fars Province),” Iranian Red Crescent Medical Journal, vol. 15, no. 3, 2013. View at: Publisher Site | Google Scholar
  10. H. M. Boye and E. Badoe, Newborn Jaundice. A Preventable Cause of Disability and Death of Babies, Graphic Communications Group Limited, Accra, Ghana, 2016.
  11. C. N. Onyearugha, A. Chapp-Jumbo, and I. O. George, “Neonatal jaundice: evaluating the knowledge and practice of expectant mothers in Aba, Nigeria,” Journal of Health Science Research, vol. 1, no. 2, pp. 42–47, 2016. View at: Publisher Site | Google Scholar
  12. M. Cheesbrough, District Laboratory Practice in Tropical Countries, Cambridge University Press, New York, NY, USA, 2nd edition, 2006. View at: Publisher Site
  13. D. E. Omekwe, M. Duke George, B. T. Kennis et al., “Survey and Management Outcome of Neonatal Jaundice from a Developing Tertiary Health Centre, Southern Nigeria,” IOSR Journal of Dental and Medical Sciences, vol. 13, no. 4, pp. 35–39, 2014. View at: Publisher Site | Google Scholar
  14. S. Menon and N. Amanullah, “Maternal and neonatal determinants of neonatal jaundice – a case control study,” Journal of Medical Science and clinical Research, vol. 05, no. 03, pp. 19659–19665, 2017. View at: Publisher Site | Google Scholar
  15. D. S. Devi and B. Vijaykumar, “Risk factors for neonatal hyperbilirubinemia: a case control study,” International Journal of Reproduction, Contraception, Obstetrics and Gynecology, vol. 6, no. 1, pp. 198–202, 2016. View at: Publisher Site | Google Scholar
  16. C. G. Scrafford, L. C. Mullany, J. Katz et al., “Incidence of and risk factors for neonatal jaundice among newborns in southern Nepal,” Tropical Medicine & International Health, vol. 18, no. 11, pp. 1317–1328, 2013. View at: Publisher Site | Google Scholar
  17. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia, “Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation,” Pediatrics, vol. 114, no. 1, pp. 297–316, 2004. View at: Publisher Site | Google Scholar
  18. T. B. Newman, B. Xiong, V. M. Gonzales, and G. J. Escobar, “Prediction and prevention of extreme neonatal hyperbilirubinemia in a mature health maintenance organization,” Archives of Pediatrics & Adolescent Medicine, vol. 154, no. 11, p. 1140, 2000. View at: Publisher Site | Google Scholar
  19. N. K. Ho, “Neonatal jaundice in Asia,” Baillière's Clinical Haematology, vol. 5, no. 1, pp. 131–142, 1992. View at: Publisher Site | Google Scholar
  20. B. K. Kalakheti, R. Singh, N. K. Bhatta, A. Karki, and N. Baral, “Risk of neonatal hyperbilirubinemia in babies born to ‘O’ positive mothers: A prospective cohort study,” Kathmandu University Medical Journal, vol. 7, no. 1, 2009. View at: Publisher Site | Google Scholar
  21. V. K. Bhutani, L. H. Johnson, and R. Keren, “Diagnosis and management of hyperbilirubinemia in the term neonate: For a safer first week,” Pediatric Clinics of North America, vol. 51, no. 4, pp. 843–861, 2004. View at: Publisher Site | Google Scholar
  22. V. K. Bhutani and R. J. Wong, “Bilirubin neurotoxicity in preterm infants: risk and prevention,” Journal of Clinical Neonatology, vol. 2, no. 2, pp. 61–69, 2013. View at: Publisher Site | Google Scholar
  23. A. K. Brown, M. H. Kim, P. Y. K. Wu, and D. A. Bryla, “Efficacy of phototherapy in prevention and management of neonatal hyperbilirubinemia,” Pediatrics, vol. 75, no. 2, pp. 393–400, 1985. View at: Google Scholar
  24. M. Chan, “Neonatal jaundice,” in Diseases of children in the tropics and subtropics, P. Stanfield, M. Brueton, M. Chan, and M. Parkin, Eds., Edward Arnold, London, 4th edition, 1994. View at: Google Scholar
  25. B. O. Olusanya, A. A. Akande, A. Emokpae, and S. A. Olowe, “Infants with severe neonatal jaundice in Lagos, Nigeria: incidence, correlates and hearing screening outcomes,” Tropical Medicine & International Health, vol. 14, no. 3, pp. 301–310, 2009. View at: Publisher Site | Google Scholar
  26. O. Goodman, O. Kehinde, B. Odugbemi, T. Femi-Adebayo, and O. Odusanya, “Neonatal Jaundice: Knowledge, Attitude and practices of mothers in Mosan-Okunola community, Lagos, Nigeria,” Nigerian Postgraduate Medical Journal , vol. 22, no. 3, p. 158, 2015. View at: Publisher Site | Google Scholar

Copyright © 2018 Prince Adoba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder
Views8213
Downloads1575
Citations

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.