proteolyt stabil gastrointestin tract blood plasma major obstacl oral peptid drug develop inhibitor cystin knot icks linear cystin knot peptid which have multifunct properti could becom promis drug scaffold protxi protxii gtx115 gsmtx4 were spiderderiv icks incub pepsin trypsin chymotrypsin elastas physiolog condit find all test peptid were resist pepsin protxii gsmtx4 gtx115 show resist all test proteas also protxii degrad observ rat blood plasma 24 hour vitro protxii concentr circul decreas half 40 min indic absolut stabil plasma fast clearanc from system far linear peptid general thought unsuit vivo all test icks were degrad pepsin stomach could select altern site drug absorpt fast onset drug action sinc spider icks select inhibitor various ion channel which relat patholog mani diseas engin icks make novel class peptid medicin which can treat varieti bother symptom

Kyoko Kikuchi

Mika Sugiura

Tadashi Kimura

High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots

chang protein conform can occur both part normal protein function dure diseas pathogenesi the most common conform diseas amyloidos sometim develop number diseas which tradit relat amyloidos associ amyloidlik conform transit protein also amyloidlik aggreg take part normal physiolog process memor cell signal sever primari structur featur protein involv conform transit also protein proteolyt fragment can caus conform transit protein short peptid which could produc dure protein life cycl which encod short open read frame can affect protein conform function

Vladimir Egorov

Natalia Grudinina

Andrey Vasin

Dmitry Lebedev

Peptide-Induced Amyloid-Like Conformational Transitions in Proteins

bartonella bacilliformi etiolog agent carrión diseas oroya fever bacilliformi infect repres interest model human host specif the notabl differ clinic present carrión diseas suggest complex adapt bacterium human host overal object persist mainten reservoir state vectori transmiss immun evas these event includ multitud biochem genet mechan involv both bacteri host protein this review focus protein involv interact between bacilliformi human host some them flagellin brps ialb ftsz hbp pap31 other outer membran protein potenti protein antigen candid synthet vaccin

Cesar Henriquez-Camacho

Palmira Ventosilla

Michael F. Minnick

Joaquim Ruiz

Ciro Maguiña

Proteins of <i>Bartonella bacilliformis</i>: Candidates for Vaccine Development

although saliva endothelin emerg valuabl noninvas cardiovascular biomark report relationship between isoform saliva plasma remain scarc measur endothelin concurr saliva plasma sampl male age 1863 hplcfluoresc result reveal statist signific posit correl among all isoform between saliva plasma big endothelin1 bet1 055 027 versus 335 128 pmol endothelin1 et1 052 021 versus 345 128 pmol endothelin2 et2 021 007 versus 163 066 pmol endothelin3 et3 039 019 versus 232 144 pmol correl bet1 et1 et3 within each compart were posit both plasma saliva wherea et2 signific correl other isoform either plasma saliva for all isoform concentr vari averag fivefold between individu 90th 10th percentil individu high plasma endothelin level general had high saliva endothelin level our result reveal salivari isoform profil portray plasmat profil support view coordin regul et1 et3 distinct regulatori pathway et2

Roma Gurusankar

Prem Kumarathasan

Anusha Saravanamuthu

Errol M. Thomson

Renaud Vincent

Correlation between Saliva and Plasma Levels of Endothelin Isoforms ET-1, ET-2, and ET-3

theoret studi conform analysi perform shortsequ hypomurocin peptid order identifi characterist structur properti for each hypomurocin molecul onli backbon conform also sidechain conform were examin the result indic certain tetrapeptid unit could character type iii turn structur consid helic conform could conclud hypomurocin peptid show prefer 3 10 helic structur over helic structur besid backbon conform sidechain conform were investig prefer rotam state sidechain amino acid were determin furthermor occurr intramolecular hbond studi which could play role structur stabil turn helic conform whole our theoret studi suppli comprehens character threedimension structur shortsequ hypomurocin peptid

Zoltán Násztor

János Horváth

Balázs Leitgeb

In Silico Conformational Analysis of the Short-Sequence Hypomurocin A Peptides

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