Novel Composite Materials for Chiral Separation from Cellulose and Barium Sulfate

Table 1

The enantioseparation evaluation of CSP 1 and CSP 2.

Chiral; analytes	CSP 1				CSP 2
	𝑘1	𝛼	𝑅𝑠	Eluent	𝑘1	𝛼	𝑅𝑠	Eluent
1	6.59	1.21	0.18	B	No separation
2	4.93	1.36	0.24	B	No separation
3	4.20	1.25	0.95	A	No separation
4	6.59	1.14	0.42	A	3.61	1.09	0.21	B
5	No separation				3.35	1.07	0.44	C
6	3.41	1.08	0.18	B	No separation
7	2.47	2.06	2.52	E	5.97	1.21	1.81	C
8	1.22	2.57	3.25	F	6.99	2.36	8.18	C
9	9.63	1.19	0.57	E	No separation
10	1.87	1.35	0.64	A	No separation
11	No separation				12.33	1.10	0.99	D
12	0.86	1.27	0.10	B	2.07	1.19	0.77	C
13	0.78	1.37	0.34	B	2.78	1.15	1.26	C
14	2.01	1.10	0.08	B	6.56	1.15	1.53	C
15	3.37	1.09	0.12	E	8.74	1.08	0.15	B
16	1.35	1.45	1.54	A	1.26	1.32	1.56	C
17	4.10	1.20	0.99	A	6.89	1.14	1.51	C
18	2.45	1.14	0.41	A	2.21	1.11	0.22	C
19	0.78	1.44	0.37	A	1.01	1.15	1.00	A
20	1.36	1.10	0.12	E	2.02	1.14	1.00	D

The retention factors (𝑘₁ and 𝑘₂) were calculated from the formulas of (𝑡₁−𝑡₀)/𝑡₀ and (𝑡₂−𝑡₀)/𝑡₀, where 𝑡₁ and 𝑡₂ are, respectively, the retention time of the first- and the second-eluted enantiomers, and 𝑡₀ is the dead time determined by using 1,3,5-tri-tertiary-butylbenzene. The separation factor (𝛼) was calculated from the formula of 𝑘₂/𝑘₁. The resolution (𝑅_𝑠) was calculated from the formula of 2(𝑡₂−𝑡₁)/(𝑤₁+𝑤₂), where 𝑤₁ and 𝑤₂ are the bandwidth of the first- and the second-eluted enantiomers, respectively.
A: 𝑛-hexane/isopropanol (90/10, 𝑣/𝑣); B: 𝑛-hexane/ethanol (90/10, 𝑣/𝑣); C: 𝑛-hexane/ethanol/methanol (90/5/5, 𝑣/𝑣/𝑣); D: 𝑛-hexane/ethanol (95/5, 𝑣/𝑣); E: 𝑛-hexane/isopropanol (70/30, 𝑣/𝑣); F: 𝑛-hexane/ethanol (70/30, 𝑣/𝑣).