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International Journal of Polymer Science
Volume 2013, Article ID 564319, 6 pages
http://dx.doi.org/10.1155/2013/564319
Research Article

A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer Formulations

1Centre for Industrial and Engineering Optics, Dublin Institute of Technology, Dublin 8, Ireland
2School of Physics, College of Sciences and Health, Dublin Institute of Technology, Dublin 8, Ireland
3Nanolab Research Centre, FOCAS, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland
4Department of Mathematics and Physics, Agricultural University, 4000 Plovdiv, Bulgaria

Received 30 May 2013; Accepted 1 August 2013

Academic Editor: Zhou Yang

Copyright © 2013 Dervil Cody et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The comparative cytotoxic evaluation of two monomers, diacetone acrylamide (DA) and acrylamide (AA) used in holographic photopolymer formulations, is reported. Two normal cell lines were used: BEAS-2B and HaCaT. Cellular viability was assessed using the MTT assay for three different exposure times. A difference of two orders of magnitude is observed in the lethal dose (LD50) concentrations of the two monomers. Diacetone acrylamide exhibits a significantly lower toxicity profile in comparison to acrylamide at all exposure times. This result justifies the replacement of acrylamide with diacetone acrylamide in the photopolymer formulation, with the view to reducing occupational hazard risks for large-scale holographic device fabrication. A comparative study investigating the holographic recording ability of the two photopolymers in transmission mode showed that the DA photopolymer is capable of reaching refractive index modulation values of , which is 80% of the refractive index modulation achieved by the AA photopolymer. This makes the DA-based photopolymers suitable for a wide range of applications.