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International Journal of Polymer Science
Volume 2013 (2013), Article ID 761870, 6 pages
http://dx.doi.org/10.1155/2013/761870
Research Article

Preparation of Polysaccharide-Based Microspheres by a Water-in-Oil Emulsion Solvent Diffusion Method for Drug Carriers

Biodegradable Polymers Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahasarakham University, Mahasarakham 44150, Thailand

Received 3 May 2013; Revised 24 July 2013; Accepted 29 July 2013

Academic Editor: Yulin Deng

Copyright © 2013 Yodthong Baimark and Yaowalak Srisuwan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Z. Gumargalieva, D. Horak, and G. E. Zaikov, “Biodegradable polymeric microparticles in biomedical applications,” International Journal of Polymeric Materials, vol. 42, no. 1-2, pp. 83–117, 1998. View at Google Scholar · View at Scopus
  2. Y. Xu, C. Zhan, L. Fan, L. Wang, and H. Zheng, “Preparation of dual crosslinked alginate-chitosan blend gel beads and in vitro controlled release in oral site-specific drug delivery system,” International Journal of Pharmaceutics, vol. 336, no. 2, pp. 329–337, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Roy, J. Bajpai, and A. K. Bajpai, “Dynamics of controlled release of chlorpyrifos from swelling and eroding biopolymeric microspheres of calcium alginate and starch,” Carbohydrate Polymers, vol. 76, no. 2, pp. 222–231, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. A. Agnihotri, N. N. Mallikarjuna, and T. M. Aminabhavi, “Recent advances on chitosan-based micro- and nanoparticles in drug delivery,” Journal of Controlled Release, vol. 100, no. 1, pp. 5–28, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. S. G. Kumbar and T. M. Aminabhavi, “Synthesis and characterization of modified chitosan microspheres: effect of the grafting ratio on the controlled release of nifedipine through microspheres,” Journal of Applied Polymer Science, vol. 89, no. 11, pp. 2940–2949, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. S. A. Agnihotri and T. M. Aminabhavi, “Controlled release of clozapine through chitosan microparticles prepared by a novel method,” Journal of Controlled Release, vol. 96, no. 2, pp. 245–259, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. K. S. V. Krishna Rao, B. Vijaya Kumar Naidu, M. C. S. Subha, M. Sairam, and T. M. Aminabhavi, “Novel chitosan-based pH-sensitive interpenetrating network microgels for the controlled release of cefadroxil,” Carbohydrate Polymers, vol. 66, no. 3, pp. 333–344, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Rokhade, N. Shelke, S. Patil, and T. Aminabhavi, “Novel hydrogel microspheres of chitosan and pluronic F-127 for controlled release of 5-fluorouracil,” Journal of Microencapsulation, vol. 24, no. 3, pp. 274–288, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. A. P. Rokhade, P. V. Kulkarni, N. N. Mallikarjuna, and T. M. Aminabhavi, “Preparation and characterization of novel semi-interpenetrating polymer network hydrogel microspheres of chitosan and hydroxypropyl cellulose for controlled release of chlorothiazide,” Journal of Microencapsulation, vol. 26, no. 1, pp. 27–36, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. S. C. Angadi, L. S. Manjeshwar, and T. M. Aminabhavi, “Interpenetrating polymer network blend microspheres of chitosan and hydroxyethyl cellulose for controlled release of isoniazid,” International Journal of Biological Macromolecules, vol. 47, no. 2, pp. 171–179, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. W. E. Rudzinski and T. M. Aminabhavi, “Chitosan as a carrier for targeted delivery of small interfering RNA,” International Journal of Pharmaceutics, vol. 399, no. 1-2, pp. 1–11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Ganguly, T. M. Aminabhavi, and A. R. Kulkarni, “Colon targeting of 5-fluorouracil using polyethylene glycol cross-linked chitosan microspheres enteric coated with cellulose acetate phthalate,” Industrial and Engineering Chemistry Research, vol. 50, no. 21, pp. 11797–11807, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. Y.-Y. Fang, L.-J. Wang, D. Li et al., “Preparation of crosslinked starch microspheres and their drug loading and releasing properties,” Carbohydrate Polymers, vol. 74, no. 3, pp. 379–384, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. M. D. Kurkuri, A. R. Kulkarni, M. Y. Kariduraganavar, and T. M. Aminabhavi, “In vitro release study of verapamil hydrochloride through sodium alginate interpenetrating monolithic membranes,” Drug Development and Industrial Pharmacy, vol. 27, no. 10, pp. 1107–1114, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. X. Zhang, Z. Hui, D. Wan et al., “Alginate microsphere filled with carbon nanotube as drug carrier,” International Journal of Biological Macromolecules, vol. 47, no. 3, pp. 389–395, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. R. C. Mundargi, N. B. Shelke, A. P. Rokhade, S. A. Patil, and T. M. Aminabhavi, “Formulation and in-vitro evaluation of novel starch-based tableted microspheres for controlled release of ampicillin,” Carbohydrate Polymers, vol. 71, no. 1, pp. 42–53, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. B.-Z. Li, L.-J. Wang, D. Li et al., “Fabrication of starch-based microparticles by an emulsification-crosslinking method,” Journal of Food Engineering, vol. 92, no. 3, pp. 250–254, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Kotsaeng, J. Karnchanajindanun, and Y. Baimark, “Chitosan microparticles prepared by the simple emulsification-diffusion method,” Particulate Science and Technology, vol. 28, no. 4, pp. 369–378, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Karnchanajindanun, M. Srisa-Ard, and Y. Baimark, “Genipin-cross-linked chitosan microspheres prepared by a water-in-oil emulsion solvent diffusion method for protein delivery,” Carbohydrate Polymers, vol. 85, no. 3, pp. 674–680, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. D. P. Chattopadhyay and M. S. Inamdar, “Aqueous behaviour of chitosan,” International Journal of Polymer Science, vol. 2010, Article ID 939536, 7 pages, 2010. View at Publisher · View at Google Scholar