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International Journal of Polymer Science
Volume 2013, Article ID 916571, 6 pages
http://dx.doi.org/10.1155/2013/916571
Research Article

Paclitaxel Release from Polyether-Anhydrides Prepared with UV-Curing Process

1College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China
2Nanjing Excellence Technology Center for Interventional Medical Devices, Nanjing 210093, China

Received 8 April 2013; Revised 23 July 2013; Accepted 2 August 2013

Academic Editor: Jan-Chan Huang

Copyright © 2013 Anxin Dong and Tao Zhang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Polyanhydrides have been used as drug delivery systems to achieve a long-term delivery due to its hydrophobicity and surface erosion degradation behavior. In order to develop a simple, economical, and rapid approach to synthesize polyanhydrides, we prepared a series of polyether-anhydride membranes composed of different mass fractions of sebacic acid, polyethylene glycol dimethacrylate, and poly(tetramethylene oxide) dimethacrylate by ultraviolet curing process. The chemical structure and thermal properties of target polyanhydrides were characterized, while the paclitaxel releases from the polymer matrix were evaluated by HPLC. The results demonstrated that the UV-curing process is a good method to synthesize the target polymers in a short time, and the paclitaxel release procedure can be controlled by changing the component in the copolymers.