Concentrated Hypoxia-Preconditioned Adipose Mesenchymal Stem Cell-Conditioned Medium Improves Wounds Healing in Full-Thickness Skin Defect Model

Figure 3

The average healing time and percentage of wound healing in each group. The average healing time of Conc. Hypo-AMSCs-CM group (10 rats) is days, Hypo-AMSCs-CM group (10 rats) is days, and the control group (10 rats) is days (a). There was significant difference between the Conc. Hypo-AMSCs-CM and Hypo-AMSCs-CM groups () and between Hypo-AMSCs-CM and control groups (). Percentage of wound healing of groups on 7, 14, and 21 days after surgery (b). The Conc. Hypo-AMSCs-CM treatment improved wound healing compared with the Hypo-AMSCs-CM at 7 and 14 () days (Figures 2(b) and 3(b)). The Hypo-AMSCs-CM group’s wound healing was also significantly different from that of the control group at 7 (), 14 (), and 21 days () (Figures 2(b) and 3(b)) too.

(a)

(b)