Rapid Screening and Quantitative Determination of Illegal Phosphodiesterase Type 5 Inhibitors (PDE-5i) in Herbal Dietary Supplements

Table 3

Concentration of PDE-5i detected in real samples.

Sample	PDE-5i	Concentration (mg/g)
S 1	Nortadalafil	50.0 ± 0.13
	Tadalafil	11.6 ± 0.05
	Sildenafil-N-oxide	∼0.073
S 2	Nortadalafil	4.41 ± 0.05
	Chloropretadalafil	∼0.006
S 3	Sildenafil	22.2 ± 0.11
	Tadalafil	0.39 ± 0.007
	Sildenafil-N-oxide	∼0.06
S 4	Propoxyphenylaildenafil	1.02 ± 0.06
	Thiohomosildenafil	0.78 ± 0.005
	Homosildenafil	∼0.031
	Methisosildenafil	∼0.03
S 5–9	Hydroxyhomosildenafil	1.05–20.1
	Hydroxythiohomosildenafil	0.78–22.5
S 10	Tadalafil	∼0.08
S 11	Tadalafil	10.2 ± 0.05
	Chloropretadalafil	5.25 ± 0.06
S 12	Nortadalafil	12.2 ± 0.05
	Chloropretadalafil	0.25 ± 0.06
S 13	Nortadalafil	10.2 ± 0.04
	Chloropretadalafil	5.25 ± 0.10
S 14	Acetil acid	0.13 ± 0.06
S 15	Tadalafil	0.12 ± 0.05
S 16	Sildenafil	5.25 ± 0.11
	Tadalafil	4.77 ± 0.15
	Aminotadalafil	0.52 ± 0.05
	Sildenafil N-oxyde	0.56 ± 0.06
S 17	Nortadalafil	0.52 ± 0.06
	Chloropretadalafil	4.77 ± 0.10
S 18	Nortadalafil	12.1 ± 0.06
M 1	Nortadalafil	170.0 ± 1.22
M 2	Hydroxythiohomosildenafil	226.8 ± 1.36
	Hydroxythiovardenafil	216.8 ± 2.00
	Propoxyphenyl-homohydroxysildenafil	0.13 ± 0.06
	Hydroxyhomo-sildenafil	∼0.048
	Hydroxyvardenafil	∼0.047

S: supplementary food, M: medicine ingredient, “S 5–9” indicates samples: S 5, S 6, S 7, S 8, S 9.