Table of Contents Author Guidelines Submit a Manuscript
Journal of Aging Research
Volume 2011, Article ID 391783, 5 pages
http://dx.doi.org/10.4061/2011/391783
Research Article

Validation of Automated White Matter Hyperintensity Segmentation

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK

Received 4 May 2011; Revised 1 July 2011; Accepted 3 July 2011

Academic Editor: Ph Scheltens

Copyright © 2011 Sean D. Smart et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Inzitari, M. Simoni, G. Pracucci et al., “Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes—the LADIS study,” Archives of Internal Medicine, vol. 167, no. 1, pp. 81–88, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Scheltens, F. Barkhof, D. Leys et al., “A semiquantitative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging,” Journal of the Neurological Sciences, vol. 114, no. 1, pp. 7–12, 1993. View at Publisher · View at Google Scholar · View at Scopus
  3. L.-O. Wahlund, F. Barkhof, F. Fazekas et al., “A new rating scale for age-related white matter changes applicable to MRI and CT,” Stroke, vol. 32, no. 6, pp. 1318–1322, 2001. View at Google Scholar · View at Scopus
  4. A. A. Gouw, W. M. van der Flier, E. C. W. van Straaten et al., “Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression,” Cerebrovascular Diseases, vol. 25, no. 3, pp. 247–253, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. C. R. Jack, P. C. O'Brien, D. W. Rettman et al., “FLAIR histogram segmentation for measurement of leukoaraiosis volume,” Journal of Magnetic Resonance Imaging, vol. 14, no. 6, pp. 668–676, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Wu, C. Rosano, M. Butters et al., “A fully automated method for quantifying and localizing white matter hyperintensities on MR images,” Psychiatry Research, vol. 148, no. 2-3, pp. 133–142, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. E. C. van Straaten, F. Fazekas, E. Rostrup et al., “Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study,” Stroke, vol. 37, no. 3, pp. 836–840, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Levy-Cooperman, J. Ramirez, N. J. Lobaugh, and S. E. Black, “Misclassified tissue volumes in Alzheimer disease patients with white matter hyperintensities: importance of lesion segmentation procedures for volumetric analysis,” Stroke, vol. 39, no. 4, pp. 1134–1141, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. J. Firbank, T. Minett, and J. T. O'Brien, “Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects,” Neurology, vol. 61, no. 7, pp. 950–954, 2003. View at Google Scholar · View at Scopus
  10. M. J. Firbank, A. M. Blamire, A. Teodorczuk et al., “High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with Lewy bodies,” Journal of Alzheimer's Disease, vol. 21, no. 4, pp. 1129–1140, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. G. McKhann, D. Drachman, and M. Folstein, “Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease,” Neurology, vol. 34, no. 7, pp. 939–944, 1984. View at Google Scholar · View at Scopus
  12. I. G. McKeith, D. W. Dickson, J. Lowe et al., “Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium,” Neurology, vol. 65, no. 12, pp. 1863–1872, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Ashburner and K. J. Friston, “Unified segmentation,” NeuroImage, vol. 26, no. 3, pp. 839–851, 2005. View at Publisher · View at Google Scholar · View at Scopus