Increase in Distant Stage Breast Cancer Incidence Rates in US Women Aged 25–49 Years, 2000–2011: The Stage Migration Hypothesis

Table 3

Three-year relative survival rate (RSR) for women diagnosed at age <50 years with invasive breast cancer in SEER registries for selected years of diagnosis by summary stage at diagnosis^a.

Years	Distant stage		Regional stage		Localized stage
	Number^b	RSR (CL)	Number^b	RSR (CL)	Number^b	RSR (CL)
Age 25–39 years
2000-01	227	30.2 (24.0, 36.4)	2634	80.8 (79.2, 82.4)	2509	95.1 (94.1, 96.1)
2007-08	335	45.4 (39.6, 51.2)^*	2418	87.2 (85.8, 88.6)^*	2355	95.7 (94.7, 96.7)
Age 40–49 years
2000-01	622	32.7 (28.9, 36.5)	6820	86.8 (86.0, 87.6)	9111	97.3 (96.9, 97.7)
2007-08	747	41.0 (37.2, 44.8)^*	6737	90.2 (89.4, 91.0)^*	9980	97.8 (97.4, 98.2)
Major ER/PR subgroups, age 25–49 years
ER positive/PR positive^c
2000-01	287	50.1 (44.1, 56.1)	4602	93.2 (92.4, 94.0)	5702	98.9 (98.5, 99.3)
2007-08	499	56.6 (51.8, 61.4)	5635	95.8 (95.2, 96.4)^*	7864	99.2 (98.8, 99.6)
ER negative/PR negative^c
2000-01	214	15.3 (10.3, 20.3)	2208	69.7 (67.7, 71.7)	2507	92.2 (90.0, 93.4)
2007-08	326	27.4 (22.2, 32.6)^*	2223	75.4 (73.4, 77.4)^*	2629	92.9 (91.7, 94.1)

^aSEER summary stage 2000 (see text) [3, 7, 8].
^bNumber of cases at start of follow-up, after exclusion of those with breast cancer as other than their first or only reportable tumor in the SEER database, and breast cancers ascertained by death certificate or autopsy only (see text). With follow-up through December 2011 [7], all cases diagnosed in 2007-08 had the potential to survive at least 3 years after diagnosis (see text).
^cEstrogen receptor (ER)/progesterone receptor (PR) (see Table 2 and text). Other ER/PR categories involved small numbers (see text).
CL: confidence limits, lower and upper (95%).
SEER: Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.
^*CL for RSR for this period do not overlap with CL for 2000-01.