Synthesis and Antidepressant Activity of Some New 5-(1H-Indol-3-yl)-3-(substituted aryl)-4,5-dihydroisoxazoline Derivatives

Table 1

Data of 5-(1H-Indol-3-yl)-3-(substituted aryl)-4,5-dihydroisoxazoline derivatives 3a–3n produced via Scheme 1.

Compound	Ar	Yield (%)^a	m.p. (°C) [lit. m.p.]
3a		87.6	61–164
3b		81.7	167-168 (167) [26]
3c		84.3	178-179
3d		74.1	198-199
3e		71.9	201–203
3f		81.2	206–208
3g		76.4	171–176
3h		74.6	207-208
3i		70.6	164–167
3j		75.1	183-184
3k		78.9	174–176
3l		77.3	181–183
3m		72.9	191–193
3n		80.6	194–197

aAll yields refer to products purified by column chromatography.