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Journal of Chemistry
Volume 2015, Article ID 171570, 4 pages
http://dx.doi.org/10.1155/2015/171570
Research Article

Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation

1Korea Food Research Institute, Seongnam 463-746, Republic of Korea
2Korea University of Science and Technology, Daejeon 305-350, Republic of Korea
3College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea

Received 12 June 2015; Revised 23 July 2015; Accepted 29 July 2015

Academic Editor: Bartolo Gabriele

Copyright © 2015 Jin Taek Hwang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The potent suppression of adipocyte differentiation by 4-(4-methylbenzamino)benzoate was discovered during the search for new antiobesity compounds. 4-(4-methylbenzamino)benzoate was observed to suppress adipocyte differentiation in 3T3-L1 cells by 96.8% at 50 μM without cytotoxicity. In addition, 4-(4-methylbenzamino)benzoate reduced the cellular expression of fatty acid synthase in a concentration-dependent manner, as well as suppressing PPAR-gamma activity, which controls fatty acid storage and glucose metabolism. Based on these results, 4-(4-methylbenzamino)benzoate shows potential as an antiobesity material.