Journal of Chemistry

Research Article

Use of Zeolite ZSM-5 for Loading and Release of 5-Fluorouracil

Table 4

Kinetic parameters of 5-FU release from sodium zeolite (ZSM-5) and the corresponding acid activated form (H-ZSM-5). Modeling of % release () was carried out utilizing each of the following models: the first-order release model , Higuchi’s first burst model , and Kopcha’s model .


		5-FU loading data		5-FU kinetic release models’ data
Zeolite		5-FU loading data
	(mg)	% loading	(mg)	(mg)	% release	(h⁻¹)	(h)

ZSM-5-(15)	49.2	22	10.8	10.47	97	2.2	1.2	11.0
H-ZSM-5-(15)	50.2	43	21.6	19.8	92	3.9	1.4	22.5
ZSM-5-(169)	50.6	38	19.2	16.2	85	2.9	1.1	2.4

= average mass of the drug-loaded sample.
= average mass of the drug in the loaded sample (obtained from % loading).
= maximum mass of drug released into the SBF buffer solution.
% release = .
= first-order rate constant.
= Higuchi first burst constant.
= ratio of diffusion-to-erosion contributions to drug release.