Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents

Table 1

Antibacterial activities of 1–12 in comparison to aspirin and control.

Compounds	E. coli		S. aureus
	Zone of inhibition (mm)	Relative inhibition zone diameter (%)	Zone of inhibition (mm)	Relative inhibition zone diameter (%)
1	7.3	45.6	8.0	72.7
2	7.7	48.1	10.7	97.3
3	10.5	65.6	—	—
4	—	—	—	—
5	10.7	66.9	11.3	>100
6	—	—	—	—
7	8.5	53.1	10.3	93.6
8	9.3	58.1	10.3	93.6
9	8.0	50.0	—	—
10	—	—	—	—
11	—	—	—	—
12	—	—	—	—
Aspirin	—	—	—	—
DMSO	—	—	—	—
Ampicillin	16.0	100	11.0	100