The Roles of Streptozotocin Neurotoxicity and Neutral Endopeptidase in Murine Experimental Diabetic Neuropathy

Figure 3

Thermal response latency in the hindpaw for C57Bl/6 and neutral endopeptidase (NEP −/−) deficient mice. Study groups included mice fed a normal diet for 12 weeks (control), streptozotocin-induced diabetes duration 12 weeks, or fed a high fat containing diet for 12 weeks. Data are the mean ± standard error of the mean. The numbers of animals for each group are the same as described in Table 1. ^∗𝑃<.05 versus control C57Bl/6, ⁺𝑃<.05 C57Bl/6 mice versus NEP −/− mice, respectively.