Cold Exposure Exacerbates the Development of Diabetic Polyneuropathy in the Rat
Figure 1
H-reflex latencies and area under the curve. (a) Graph of H-reflex latencies shows differences among the treatment groups (open circles = nondiabetic room temperature , open squares = nondiabetic cold , filled circles = diabetic room temperature , and filled squares = diabetic cold ). At 10 weeks, diabetic animals exposed to a cold environment had a significant increase in H-reflex latency as compared to diabetic animals exposed to a room temperature environment, nondiabetic animals exposed to a cold environment, and nondiabetic animals exposed to a room temperature environment. Mean ± SEM. versus all other groups. versus weeks 0–6. (b) Calculated area under the curve (AUC) of H-reflex latency from 0 to 10 weeks, derived from Figure 1(a). Diabetic animals had larger H-reflex latency AUCs than nondiabetic controls. Mean ± SEM. for diabetes, for temperature, and for the interaction term. (c) Calculated AUC of H-reflex latency from 0 to 16 weeks derived from Figure 1(a). Although diabetic animals in both groups (room temperature and cold) had greater AUCs than nondiabetic controls, the temperature and interaction effects were no longer apparent. Mean ± SEM. versus nondiabetic controls.
