Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice
Figure 3
Ablation of floxed Men1 does not affect the number of glucagon-secreting alpha cells and serum glucagon levels in STZ-treated mice. Study design was described in Figure 1(c). Control ( mice) and ; Cre-ER mice ( mice) were fed TAM at age of 12 weeks. Four weeks after the last dose of TAM feeding, STZ was i.p. injected at 40 mg/kg of body weight per day for 5 consecutive days. Pancreata and blood serum were collected from mice for further analysis, 4 weeks after STZ injections. (a) Quantitation of number of alpha cells in islets ( mice). (b) Quantitation of the percentage of alpha cells in islets ( mice). (c) Non-fasting serum glucagon levels before and 4 weeks after STZ injections ( to 21 mice). *, .
