Altered Expression of Somatostatin Receptors in Pancreatic Islets from NOD Mice Cultured at Different Glucose Concentrations In Vitro and in Islets Transplanted to Diabetic NOD Mice In Vivo

Table 1

Summary of changes in islet cell sst expression in islets cultured at high glucose and in islet transplanted to hyperglycemic NOD mice.

	Cultured islets				Transplanted islets
	28 mM glucose versus 5.6 mM glucose				Diabetic versus normoglycemic
Cell	𝛼	𝛽	𝛿	PP	𝛼	𝛽	𝛿	PP
sst1	→	→	→	↑	→	↓	→	→
sst2	→	→	→	→	→	→	→	↓
sst3	→	↑	→	↓	→	→	→	→
sst4	→	→	→	→	→	→	→	↑
sst5	↓	↓	↑	→	→	→	→	→

→ denotes no significant change, ↓ denotes a decline in the fraction of cells expressing the sst, and ↑ denotes an increase in the fraction of cells expressing the sst.