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Experimental Diabetes Research
Volume 2012, Article ID 187018, 11 pages
http://dx.doi.org/10.1155/2012/187018
Review Article

The Role of Glucosamine-Induced ER Stress in Diabetic Atherogenesis

1Thrombosis and Atherosclerosis Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON, Canada L8L 2X2
2Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5
3Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5

Received 29 July 2011; Accepted 27 November 2011

Academic Editor: Muthuswamy Balasubramanyam

Copyright © 2012 Daniel R. Beriault and Geoff H. Werstuck. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cardiovascular disease (CVD) is the major cause of mortality in individuals with diabetes mellitus. However the molecular and cellular mechanisms that predispose individuals with diabetes to the development and progression of atherosclerosis, the underlying cause of most CVD, are not understood. This paper summarizes the current state of our knowledge of pathways and mechanisms that may link diabetes and hyperglycemia to atherogenesis. We highlight recent work from our lab, and others', that supports a role for ER stress in these processes. The continued investigation of existing pathways, linking hyperglycemia and diabetes mellitus to atherosclerosis, and the identification of novel mechanisms and targets will be important to the development of new and effective antiatherosclerotic therapies tailored to individuals with diabetes.