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Experimental Diabetes Research
Volume 2012, Article ID 351974, 7 pages
http://dx.doi.org/10.1155/2012/351974
Research Article

Predictors of Impaired Glucose Regulation in Patients with Non-Alcoholic Fatty Liver Disease

12nd Department of Internal Medicine, Research Institute and Diabetes Center, University of Athens Medical School, Attikon University Hospital, 12462 Athens, Greece
2Alfa Institute of Biomedical Sciences (AIBS), Marousi, 15123 Athens, Greece
34th Department of Internal Medicine, University of Athens Medical School, Attikon University Hospital, 12462 Athens, Greece
4Department of Medicine, Henry Dunant Hospital, 11526 Athens, Greece
5Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA

Received 15 June 2011; Accepted 11 July 2011

Academic Editor: Faidon Magkos

Copyright © 2012 Erifili Hatziagelaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Many patients with non-alcoholic fatty liver disease (NAFLD) have impaired glucose regulation or type 2 diabetes mellitus (DM). We investigated characteristics of NAFLD patients associated with hyperglycemia. Methods. During a 2-hour oral glucose tolerance test (OGTT), serum glucose and insulin were measured in 152 NAFLD patients. Results. 48.7% of NAFLD patients had hyperglycemia. Age (odds ratio , 95% confidence interval (CI): 1.03–1.13), body mass index (BMI) ( , 95% CI: 1.01–1.25), and lower high-density lipoprotein cholesterol (HDL-C) ( , 95% CI: 0.92–0.98) proved to be independent predictors of hyperglycemia. After OGTT, 30 min insulin was lower in hyperglycemic patients ( versus μIU/ml, ), while 90 min insulin ( versus μU/ml, ) and 120 min insulin ( versus μIU/ml, ) were higher. Conclusions. NAFLD patients with higher BMI, lower HDL-C, or older age were more likely to have impaired glucose metabolism. An OGTT could be of value for early diagnosis of DM among this population.