Table of Contents Author Guidelines Submit a Manuscript
Experimental Diabetes Research
Volume 2012, Article ID 762565, 8 pages
http://dx.doi.org/10.1155/2012/762565
Research Article

Pentoxifylline Attenuates Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis by Suppressing TNF-α Expression and Endoplasmic Reticulum Stress

1Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea
2College of Biomedical Sciences, CHA University, Seongnam 463-836, Republic of Korea
3Advanced Institutes of Convergence Technology (AICT), Seoul National University, Suwon 443-270, Republic of Korea

Received 7 June 2011; Revised 27 September 2011; Accepted 20 October 2011

Academic Editor: Lalit P. Singh

Copyright © 2012 Min Kyung Chae et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Angulo, “Medical progress: nonalcoholic fatty liver disease,” New England Journal of Medicine, vol. 346, no. 16, pp. 1221–1231, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. P. J. Barter, “The causes and consequences of low levels of high density lipoproteins in patients with diabetes,” Diabetes Metabolism Journal, vol. 35, no. 2, pp. 101–106, 2011. View at Google Scholar
  3. S. E. Shoelson, J. Lee, and A. B. Goldfine, “Inflammation and insulin resistance,” Journal of Clinical Investigation, vol. 116, no. 7, pp. 1793–1801, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. M. Lee, D. S. Sutedja, C. T. Wai et al., “A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH),” Hepatology International, vol. 2, no. 2, pp. 196–201, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. E. F. Georgescu and M. Georgescu, “Therapeutic options in non-alcoholic steatohepatitis (NASH). Are all agents alike? Results of a preliminary study,” Journal of Gastrointestinal and Liver Diseases, vol. 16, no. 1, pp. 39–46, 2007. View at Google Scholar · View at Scopus
  6. M. Kugelmas, D. B. Hill, B. Vivian, L. Marsano, and C. J. McClain, “Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E,” Hepatology, vol. 38, no. 2, pp. 413–419, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. W. Li, L. Zheng, C. Sheng, X. Cheng, L. Qing, and S. Qu, “Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease,” Lipids in Health and Disease, vol. 10, article 49, 2011. View at Publisher · View at Google Scholar
  8. P. S. Bahra, G. E. Rainger, J. L. Wautier, and G. B. Nash, “Effects of pentoxifylline on the different steps during adhesion and transendothelial migration of flowing neutrophils,” Cell Biochemistry and Function, vol. 19, no. 4, pp. 249–257, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Zhang, S. Wang, J. Malhotra et al., “The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis,” EMBO Journal, vol. 30, no. 7, pp. 1357–1375, 2011. View at Publisher · View at Google Scholar
  10. S. K. Satapathy, P. Sakhuja, V. Malhotra, B. C. Sharma, and S. K. Sarin, “Beneficial effects of pentoxifylline on hepatic steatosis, fibrosis and necroinflammation in patients with non-alcoholic steatohepatitis,” Journal of Gastroenterology and Hepatology, vol. 22, no. 5, pp. 634–638, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Malhi and G. J. Gores, “Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease,” Seminars in Liver Disease, vol. 28, no. 4, pp. 360–369, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Puri, F. Mirshahi, O. Cheung et al., “Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease,” Gastroenterology, vol. 134, no. 2, pp. 568–576, 2008. View at Publisher · View at Google Scholar · View at Scopus