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Experimental Diabetes Research
Volume 2012 (2012), Article ID 859395, 8 pages
http://dx.doi.org/10.1155/2012/859395
Research Article

A Comparison of Inflammatory and Oxidative Stress Markers in Adipose Tissue from Weight-Matched Obese Male and Female Mice

1Department of Nutrition and Exercise Physiology, University of Missouri-Columbia, 256 William Stringer Wing, Columbia, MO 65211, USA
2Department of Animal Science, Iowa State University, Ames, IA 50011, USA
3Department of Food Science, University of Missouri-Columbia, 256 William Stringer Wing, Columbia, MO 65211, USA

Received 9 February 2012; Accepted 16 April 2012

Academic Editor: Pietro Galassetti

Copyright © 2012 Karen J. Nickelson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Abbasi, B. W. Brown Jr., C. Lamendola, T. McLaughlin, and G. M. Reaven, “Relationship between obesity, insulin resistance, and coronary heart disease risk,” Journal of the American College of Cardiology, vol. 40, no. 5, pp. 937–943, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. K. M. Flegal, B. I. Graubard, D. F. Williamson, and M. H. Gail, “Cause-specific excess deaths associated with underweight, overweight, and obesity,” Journal of the American Medical Association, vol. 298, no. 17, pp. 2028–2037, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. C. de Luca and J. M. Olefsky, “Inflammation and insulin resistance,” FEBS Letters, vol. 582, no. 1, pp. 97–105, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. A. W. Ferrante Jr., “Obesity-induced inflammation: a metabolic dialogue in the language of inflammation,” Journal of Internal Medicine, vol. 262, no. 4, pp. 408–414, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. G. S. Hotamisligil, “Inflammation and metabolic disorders,” Nature, vol. 444, no. 7121, pp. 860–867, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. K. J. Strissel, Z. Stancheva, H. Miyoshi et al., “Adipocyte death, adipose tissue remodeling, and obesity complications,” Diabetes, vol. 56, no. 12, pp. 2910–2918, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. C. N. Lumeng, S. M. DeYoung, J. L. Bodzin, and A. R. Saltiel, “Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity,” Diabetes, vol. 56, no. 1, pp. 16–23, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. M. F. Gregor and G. S. Hotamisligil, “Thematic review series: adipocyte biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease,” Journal of Lipid Research, vol. 48, no. 9, pp. 1905–1914, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Furukawa, T. Fujita, M. Shimabukuro et al., “Increased oxidative stress in obesity and its impact on metabolic syndrome,” Journal of Clinical Investigation, vol. 114, no. 12, pp. 1752–1761, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. L. M. Brown, L. Gent, K. Davis, and D. J. Clegg, “Metabolic impact of sex hormones on obesity,” Brain Research, vol. 1350, pp. 77–85, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. J. M. Bruun, C. B. Nielsen, S. B. Pedersen, A. Flyvbjerg, and B. Richelsen, “Estrogen reduces pro-inflammatory cytokines in rodent adipose tissue: studies in vivo and in vitro,” Hormone and Metabolic Research, vol. 35, no. 3, pp. 142–146, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. M. R. Meyer, D. J. Clegg, E. R. Prossnitz, and M. Barton, “Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors,” Acta Physiologica, vol. 203, no. 1, pp. 259–269, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. R. E. Stubbins, K. Najjar, V. B. Holcomb, J. Hong, and N. P. Nunez, “Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance,” Diabetes, Obesity and Metabolism, vol. 14, no. 1, pp. 58–66, 2012. View at Publisher · View at Google Scholar
  14. R. E. Stubbins, V. B. Holcomb, J. Hong, and N. P. Nunez, “Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance,” European Journal of Nutrition. In press. View at Publisher · View at Google Scholar
  15. K. L. Grove, S. K. Fried, A. S. Greenberg, X. Q. Xiao, and D. J. Clegg, “A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice,” International Journal of Obesity, vol. 34, no. 6, pp. 989–1000, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. D. J. Clegg, L. M. Brown, S. C. Woods, and S. C. Benoit, “Gonadal hormones determine sensitivity to central leptin and insulin,” Diabetes, vol. 55, no. 4, pp. 978–987, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. N. H. Rogers, J. W. Perfield, K. J. Strissel, M. S. Obin, and A. S. Greenberg, “Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity,” Endocrinology, vol. 150, no. 5, pp. 2161–2168, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Kamei, M. Suzuki, H. Miyazaki et al., “Ovariectomy in mice decreases lipid metabolism-related gene expression in adipose tissue and skeletal muscle with increased body fat,” Journal of Nutritional Science and Vitaminology, vol. 51, no. 2, pp. 110–117, 2005. View at Google Scholar · View at Scopus
  19. S. P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R. L. Leibel, and A. W. Ferrante Jr., “Obesity is associated with macrophage accumulation in adipose tissue,” Journal of Clinical Investigation, vol. 112, no. 12, pp. 1796–1808, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Cinti, G. Mitchell, G. Barbatelli et al., “Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans,” Journal of Lipid Research, vol. 46, no. 11, pp. 2347–2355, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. J. W. Perfield II, Y. Lee, G. I. Shulman et al., “Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance,” Diabetes, vol. 60, no. 4, pp. 1168–1176, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. T. T. Tran, Y. Yamamoto, S. Gesta, and C. R. Kahn, “Beneficial effects of subcutaneous fat transplantation on metabolism,” Cell Metabolism, vol. 7, no. 5, pp. 410–420, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. T. M. D'Eon, S. C. Souza, M. Aronovitz, M. S. Obin, S. K. Fried, and A. S. Greenberg, “Estrogen regulation of adiposity and fuel partitioning: evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways,” The Journal of Biological Chemistry, vol. 280, no. 43, pp. 35983–35991, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. M. J. Romero-Aleshire, M. K. Diamond-Stanic, A. H. Hasty, P. B. Hoyer, and H. L. Brooks, “Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome,” American Journal of Physiology, vol. 297, no. 3, pp. R587–R592, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Lin, P. K. Saha, X. Ma et al., “Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues,” Aging Cell, vol. 10, no. 6, pp. 996–1010, 2011. View at Google Scholar
  26. Y. Macotela, J. Boucher, T. T. Tran, and C. R. Kahn, “Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism,” Diabetes, vol. 58, no. 4, pp. 803–812, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. K. J. Strissel, J. DeFuria, M. E. Shaul, G. Bennett, A. S. Greenberg, and M. S. Obin, “T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice,” Obesity, vol. 18, no. 10, pp. 1918–1925, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. C. N. Lumeng, J. L. Bodzin, and A. R. Saltiel, “Obesity induces a phenotypic switch in adipose tissue macrophage polarization,” Journal of Clinical Investigation, vol. 117, no. 1, pp. 175–184, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. R. S. Ahima and S. Y. Osei, “Adipokines in obesity,” Frontiers of Hormone Research, vol. 36, pp. 182–197, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Nishizawa, L. Shimomura, K. Kishida et al., “Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein,” Diabetes, vol. 51, no. 9, pp. 2734–2741, 2002. View at Google Scholar · View at Scopus
  31. F. Bäckhed, H. Ding, T. Wang et al., “The gut microbiota as an environmental factor that regulates fat storage,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 44, pp. 15718–15723, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Handa, S. Tateya, N. O. Rizzo et al., “Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 12, pp. 2827–2835, 2011. View at Google Scholar
  33. A. Georgescu, D. Popov, A. Constantin et al., “Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with type 2 diabetes,” Clinical Science, vol. 120, no. 10, pp. 463–472, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. J. M. Curtis, P. A. Grimsrud, W. S. Wright et al., “Downregulation of adipose glutathione S-tansferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction,” Diabetes, vol. 59, no. 5, pp. 1132–1142, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. D. Pitocco, F. Zaccardi, E. Di Stasio et al., “Oxidative stress, nitric oxide, and diabetes,” Review of Diabetic Studies, vol. 7, no. 1, pp. 15–25, 2010. View at Publisher · View at Google Scholar · View at Scopus