Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2013, Article ID 103731, 9 pages
http://dx.doi.org/10.1155/2013/103731
Research Article

A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat

1Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
2Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
3Hoshino Laboratory Animals, Inc., Ibaraki 306-0606, Japan
4Animal Research Center, Tokyo Medical University, Tokyo 160-8402, Japan
5Japan SLC, Inc., Hamamatsu 431-1103, Japan
6Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
7The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan

Received 22 November 2012; Accepted 4 January 2013

Academic Editor: Takahisa Yamada

Copyright © 2013 Norihide Yokoi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [27 citations]

The following is the list of published articles that have cited the current article.

  • C. Lisa Kurtz, Bailey C. E. Peck, Emily E. Fannin, Carine Beysen, Ji Miao, Stuart R. Landstreet, Shengli Ding, Vandana Turaga, P. Kay Lund, Scott Turner, Sudha B. Biddinger, Kasey C. Vickers, and Praveen Sethupathy, “MicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes,” Diabetes, vol. 63, no. 9, pp. 3141–3148, 2014. View at Publisher · View at Google Scholar
  • Jorge Reyes-Esparza, Brissa Mendoza-Rivera, Ricardo De La Cruz-Cordero, Miguel Ángel Duarte-Vázquez, Jorge Luis Rosado, and Lourdes Rodríguez-Fragoso, “Pharmacokinetic and pharmacological effects of β-hydroxyphosphocarnitine in animal models,” Pharmacology, vol. 94, pp. 90–98, 2014. View at Publisher · View at Google Scholar
  • Krisztina Szabadfi, Erika Pinter, Dora Reglodi, and Robert Gabriel, “Neuropeptides, Trophic Factors, and Other Substances Providing Morphofunctional and Metabolic Protection in Experimental Models of Diabetic Retinopathy,” vol. 311, pp. 1–121, 2014. View at Publisher · View at Google Scholar
  • Norihide Yokoi, “Elucidation of genetic factors in diabetes based on studies of animal models,” Diabetology International, 2015. View at Publisher · View at Google Scholar
  • Ghupurjan Gheni, Norihide Yokoi, Masayuki Beppu, Takuro Yamaguchi, Shihomi Hidaka, Ayako Kawabata, Yoshikazu Hoshino, Masayuki Hoshino, and Susumu Seino, “Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat,” Journal of Diabetes Research, vol. 2015, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • M. Pereira, S. Gohin, N. Lund, A. Hvid, P. J. Smitham, M. J. Oddy, I. Reichert, D. Farlay, J. P. Roux, M. E. Cleasby, and C. Chenu, “Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus,” Osteoporosis International, 2016. View at Publisher · View at Google Scholar
  • Yunliang Yang, Zaiwang Zhang, Jiao Guan, Jiabao Liu, Pengyu Ma, Kunfeng Gu, Jianhui Zhao, Guangyao Yang, and Tieying Song, “Administrations of Thalidomide into the Rostral Ventromedial Medulla Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats,” Brain Research Bulletin, 2016. View at Publisher · View at Google Scholar
  • Kartik T. Nakhate, Sadanand U. Yedke, Ashish P. Bharne, Nishikant K. Subhedar, and Dadasaheb M. Kokare, “Evidence for the involvement of neuropeptide Y in the antidepressant effect of imipramine in type 2 diabetes,” Brain Research, 2016. View at Publisher · View at Google Scholar
  • Hao Feng, Guodong Lu, Qingsong Li, and Zhonghao Liu, “Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats,” Canadian Journal of Diabetes, 2016. View at Publisher · View at Google Scholar
  • Jinshan Shi, Ke Jiang, and Zhaoduan Li, “Involvement of spinal glutamate transporter-1 in the development of mechanical allodynia and hyperalgesia associated with type 2 diabetes,” Journal of Pain Research, vol. 9, pp. 1121–1129, 2016. View at Publisher · View at Google Scholar
  • Yu Dong, Yi-Tao Chen, Yuan-Xiao Yang, Dan Shou, and Chang-Yu Li, “Urinary Metabolomic Profiling in Zucker Diabetic Fatty Rats with Type 2 Diabetes Mellitus Treated with Glimepiride, Metformin, and Their Combination,” Molecules, vol. 21, no. 12, pp. 1446, 2016. View at Publisher · View at Google Scholar
  • Chunyan Gu, Shu Li, Lina Liang, Hua Sui, Libin Zhan, Ye Yang, Hong Xiang, and Xiaoguang Lu, “Deciphering bacterial community changes in zucker diabetic fatty rats based on 16S rRNA gene sequences analysis,” Oncotarget, vol. 7, no. 31, pp. 48941–48952, 2016. View at Publisher · View at Google Scholar
  • Kasi C. McPherson, Lateia Taylor, Michael R. Garrett, Ashley C. Johnson, Sean P. Didion, Aron M. Geurts, and Jan M. Williams, “Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats,” American Journal of Physiology - Renal Physiology, vol. 311, no. 4, pp. F793–F804, 2016. View at Publisher · View at Google Scholar
  • Yuriy Slyvka, Ramiro Malgor, Sharon R. Inman, Julia Ding, Victor Heh, and Felicia V. Nowak, “Antioxidant diet and sex interact to regulate NOS isoform expression and glomerular mesangium proliferation in Zucker diabetic rat kidney,” Acta Histochemica, vol. 118, no. 2, pp. 183–193, 2016. View at Publisher · View at Google Scholar
  • Ana Maria Olivares, Kristen Althoff, Gloria Fanghua Chen, Siqi Wu, Margaux A. Morrisson, Margaret M. DeAngelis, and Neena Haider, “Animal Models of Diabetic Retinopathy,” Current Diabetes Reports, vol. 17, no. 10, 2017. View at Publisher · View at Google Scholar
  • Huanyuan Wang, Yi Zhou, Zhiying Guo, Yu Dong, Jiahui Xu, Haixia Huang, Huirong Liu, and Wen Wang, “Sitagliptin Attenuates Endothelial Dysfunction of Zucker Diabetic Fatty Rats,” Journal of Cardiovascular Pharmacology and Therapeutics, pp. 107424841771500, 2017. View at Publisher · View at Google Scholar
  • Sebastian Steven, Matthias Oelze, Alina Hanf, Swenja Kr?ller-Sch?n, Fatemeh Kashani, Siyer Roohani, Philipp Welschof, Maximilian Kopp, Ute G?dtel-Armbrust, Ning Xia, Huige Li, Eberhard Schulz, Karl J. Lackner, Leszek Wojnowski, Serge P. Bottari, Philip Wenzel, Eric Mayoux, Thomas M?nzel, and Andreas Daiber, “The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats,” Redox Biology, 2017. View at Publisher · View at Google Scholar
  • Dorte X. Gram, Jens J. Holst, and Arpad Szallasi, “TRPV1: A Potential Therapeutic Target in Type 2 Diabetes and Comorbidities?,” Trends in Molecular Medicine, vol. 23, no. 11, pp. 1002–1013, 2017. View at Publisher · View at Google Scholar
  • Kaviyarasi Renu, Tirupathi Pichiah, Thabassum Akthar Syeda, Sankarganesh Arunachalam, and Abilash, “Adriamycin-induced cardiomyopathy can serve as a model for diabetic cardiomyopathy – a hypothesis,” Asian Pacific Journal of Tropical Biomedicine, vol. 7, no. 11, pp. 1041–1045, 2017. View at Publisher · View at Google Scholar
  • Xixi Chen, Tao Su, Yao Chen, Yingge He, Ying Liu, Yong Xu, Yan Wei, Juan Li, and Rongqiao He, “d -Ribose as a Contributor to Glycated Haemoglobin,” EBioMedicine, 2017. View at Publisher · View at Google Scholar
  • Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, and Yoshinori Seko, “Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in High Glucose-Induced Apoptosis in Rat Cardiac Myocytes and Murine Pancreatic β-Cells,” Cells, vol. 6, no. 4, pp. 35, 2017. View at Publisher · View at Google Scholar
  • Takashi Kuramoto, Naomi Kashiwazaki, Norihide Yokoi, and Satoshi Nakanishi, “Genetic profiling of two phenotypically distinct outbred rats derived from a colony of the Zucker fatty rats maintained at Tokyo Medical University,” Experimental Animals, vol. 66, no. 2, pp. 91–98, 2017. View at Publisher · View at Google Scholar
  • Marcela Capcarova, Anna Kalafova, Marianna Schwarzova, Marta Soltesova Prnova, Karol Svik, Monika Schneidgenova, Lukas Slovak, Ivana Bovdisova, Robert Toman, Viktoria Lory, and Stefan Zorad, “The high-energy diet affecting development of diabetes symptoms in Zucker diabetic fatty rats,” Biologia, 2018. View at Publisher · View at Google Scholar
  • Tomoe Tsuboi, Morihiko Maeda, and Toshio Hayashi, “Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence,” Plos One, vol. 13, no. 2, pp. e0192252, 2018. View at Publisher · View at Google Scholar
  • Monika Wolak, Teresa Staszewska, Marlena Juszczak, Małgorzata Gałdyszyńska, and Ewa Bojanowska, “Anti-inflammatory and pro-healing impacts of exendin-4 treatment in Zucker diabetic rats: Effects on skin wound fibroblasts,” European Journal of Pharmacology, 2018. View at Publisher · View at Google Scholar
  • Erika Tarasco, Giovanni Pellegrini, Lynda Whiting, and Thomas A. Lutz, “Phenotypical heterogeneity in responder and nonresponder male ApoE*3Leiden.CETP mice,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 315, no. 4, pp. G602–G617, 2018. View at Publisher · View at Google Scholar
  • A. Prasanth Saraswati, Bathini Nagendra Babu, Ahmed Kamal, Ali Hussaini, and Namballa Hari Krishna, “Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions,” European Journal of Medicinal Chemistry, vol. 144, pp. 843–858, 2018. View at Publisher · View at Google Scholar