Ethyl Pyruvate Inhibits Retinal Pathogenic Neovascularization by Downregulating HMGB1 Expression
Figure 1
The effect of EP on retinal neovascularization in OIR mice. (a) The retinal vasculature was determined by fluorescein angiography using FITC-dextran. Whole mount retinal preparation from P17 control (Con), OIR (OIR), 50 mg/kg EP-treated (EP-50), and 100 mg/kg EP-treated (EP-100) mice. (b) Quantitative analyses revealed that EP treatment significantly reduced the area of neovascularization in retinas compared with OIR. The data are expressed as the mean ± SE . versus the OIR group.
