Ethyl Pyruvate Inhibits Retinal Pathogenic Neovascularization by Downregulating HMGB1 Expression
Figure 2
The effect of EP on retinal neovascular tufts in OIR mice. (a) The retinal neovascular tufts were determined using isolectin B4 staining. The retinal preparation from P17 control (Con), OIR (OIR), 50 mg/kg EP-treated (EP-50), and 100 mg/kg EP-treated (EP-100) mice. (b) The arrows indicate neovascular tufts of intravitreous neovascularization. Hematoxylin and eosin-stained cross-section preparations are from P17 OIR (OIR) 50 mg/kg EP-treated (EP-50) and 100 mg/kg EP-treated (EP-100) mice. (c) Quantitative analyses revealed that EP treatment significantly reduced the retinal neovascular tufts compared with OIR. The data are expressed as the mean ± SE . versus the OIR group.
