Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes
Figure 7
Tregitope effect in TCR-transgenic mice. DO11.10 FoxP3/GFP transgenic mice were immunized with mT167/mT289/IFA and an irrelevant peptide HA (influenza hemagglutinin, Table 2) in IFA. After 10 days, mice were sacrificed and assayed for (a) T cell proliferation by in vitro culture with pOVA, and (b) FoxP3/GFP (Tregs) expression by FACS after CD4 and KJ1-26 staining. Gamma interferon expression in cell-culture supernatants was also suppressed (data not shown).
