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Journal of Diabetes Research
Volume 2013, Article ID 761314, 11 pages
Review Article

Cardiovascular Changes in Animal Models of Metabolic Syndrome

1Laboratório de Experimentação Animal e Laboratório de Cardiologia Celular e Molecular, Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia do Rio Grande do Sul, Porto Alegre, Brazil
2Divisão de Endocrinologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
3Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, Brazil
4Unidade de Hipertensão, Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
5Laboratório de Fisiologia Translacional, Universidade Nove de Julho, São Paulo, Brazil

Received 12 December 2012; Revised 6 February 2013; Accepted 12 February 2013

Academic Editor: Tomohiko Sasase

Copyright © 2013 Alexandre M. Lehnen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metabolic syndrome has been defined as a group of risk factors that directly contribute to the development of cardiovascular disease and/or type 2 diabetes. Insulin resistance seems to have a fundamental role in the genesis of this syndrome. Over the past years to the present day, basic and translational research has used small animal models to explore the pathophysiology of metabolic syndrome and to develop novel therapies that might slow the progression of this prevalent condition. In this paper we discuss the animal models used for the study of metabolic syndrome, with particular focus on cardiovascular changes, since they are the main cause of death associated with the condition in humans.