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Journal of Diabetes Research
Volume 2013, Article ID 906590, 12 pages
Review Article

Animal Models of GWAS-Identified Type 2 Diabetes Genes

1Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London SW7 2AZ, UK
2Biophotonics Section, Department of Physics, Imperial College London, London SW7 2AZ, UK

Received 4 February 2013; Accepted 18 March 2013

Academic Editor: Daisuke Koya

Copyright © 2013 Gabriela da Silva Xavier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example, those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse models. We discuss here the animal models available for the latter genes and provide perspectives for future, higher throughput approaches towards efficiently mining the information provided by human genetics.