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Journal of Diabetes Research
Volume 2014, Article ID 629016, 5 pages
http://dx.doi.org/10.1155/2014/629016
Research Article

Ocular Inflammation in Uveal Tract in Aged Obese Type 2 Diabetic Rats (Spontaneously Diabetic Torii Fatty Rats)

1Japan Tobacco Inc., Central Pharmaceutical Research Institute, Toxicology Research Laboratories, 23 Naganuki, Hadano, Kanagawa 257-0024, Japan
2Japan Tobacco Inc., Central Pharmaceutical Research Institute, Biological/Pharmacological Research Laboratories, Osaka 569-1125, Japan
3Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan

Received 3 July 2014; Revised 2 September 2014; Accepted 4 September 2014; Published 14 September 2014

Academic Editor: Masami Shinohara

Copyright © 2014 Yusuke Kemmochi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. W. Read, “Uveitis: Advances in understanding of pathogenesis and treatment,” Current Rheumatology Reports, vol. 8, no. 4, pp. 260–266, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Lin, E. B. Suhler, and J. T. Rosenbaum, “The future of uveitis treatment,” Ophthalmology, vol. 121, no. 1, pp. 365–376, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Masuyama, Y. Katsuda, and M. Shinohara, “A novel model of obesity-related diabetes: Introgression of the Leprfa allele of the Zucker fatty rat into nonobese Spontaneously Diabetic Torii (SDT) rats,” Experimental Animals, vol. 54, no. 1, pp. 13–20, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Matsui, T. Ohta, T. Oda et al., “Diabetes-associated complications in Spontaneously Diabetic Torii fatty rats,” Experimental Animals, vol. 57, no. 2, pp. 111–121, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Ishii, T. Ohta, T. Sasase et al., “Pathophysiological analysis of female spontaneously diabetic torii fatty rats,” Experimental Animals, vol. 59, no. 1, pp. 73–84, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Kemmochi, K. Fukui, M. Maki et al., “Metabolic disorders and diabetic complications in spontaneously diabetic Torii Leprfa rat: a new obese type 2 diabetic model,” Journal of Diabetes Research, vol. 2013, Article ID 948257, 9 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Katsuda, T. Ohta, K. Miyajima et al., “Diabetic complications in obese type 2 diabetic rat models,” Experimental Animals, vol. 63, no. 2, pp. 121–132, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Rothova, H. J. Buitenhuis, C. Meenken et al., “Uveitis and systemic disease,” The British Journal of Ophthalmology, vol. 76, no. 3, pp. 137–141, 1992. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Rothova, C. Meenken, R. P. J. Michels, and A. Kijlstra, “Uveitis and diabetes mellitus,” The American Journal of Ophthalmology, vol. 106, no. 1, pp. 17–20, 1988. View at Google Scholar · View at Scopus
  10. N. Kitaichi and S. Ohno, “Kosai-en [Iritis],” in Ganka Shinryo Practice (Pract ophthal), M. Wakura, Ed., pp. 162–164, Bunkodo, Tokyo, Japan, 7th edition, 2006. View at Google Scholar
  11. J. Greenwood, “The blood-retinal barrier in experimental autoimmune uveoretinitis (EAU): a review,” Current Eye Research, vol. 11, pp. 25–32, 1992. View at Google Scholar · View at Scopus
  12. K. Yamashiro, S. Ishida, T. Usui, Y. Kaji, and Y. Ogura, “VEGF dependent leukocyte infiltration and blood-retinal barrier breakdown in endotoxin-induced uveitis,” Investigative Ophthalmology & Visual Science, vol. 44, p. U215, 2003. View at Google Scholar
  13. U. Pleyer and J. V. Forrester, Eds., Uveitis and Immunological Disorders: Progress III, Springer, New York, NY, USA, 2010.
  14. G. Naguib, H. Al-Mashat, T. Desta, and D. T. Graves, “Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation,” Journal of Investigative Dermatology, vol. 123, no. 1, pp. 87–92, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Guo and L. A. DiPietro, “Critical review in oral biology & medicine: factors affecting wound healing,” Journal of Dental Research, vol. 89, no. 3, pp. 219–229, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Rossi, M. D'Amico, A. Capuano, M. Romano, P. Petronella, and C. di Filippo, “Hyperglycemia in streptozotocin-induced diabetes leads to persistent inflammation and tissue damage following uveitis due to reduced levels of ciliary body heme oxygenase-1,” Mediators of Inflammation, vol. 2006, Article ID 60285, 6 pages, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Okumura, M. Mochizuki, M. Nishi, and C. P. Herbort, “Endotoxin-induced uveitis (EIU) in the rat: a study of inflammatory and immunological mechanisms,” International Ophthalmology, vol. 14, no. 1, pp. 31–36, 1990. View at Publisher · View at Google Scholar · View at Scopus
  18. R. R. Caspi, “A look at autoimmunity and inflammation in the eye,” Journal of Clinical Investigation, vol. 120, no. 9, pp. 3073–3083, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. C. H. Kim, “Homeostatic and pathogenic extramedullary hematopoiesis,” Journal of Blood Medicine, vol. 1, pp. 13–19, 2010. View at Publisher · View at Google Scholar
  20. A. W. Suttie, “Histopathology of the spleen,” Toxicologic Pathology, vol. 34, no. 5, pp. 466–503, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Y. Donath and S. E. Shoelson, “Type 2 diabetes as an inflammatory disease,” Nature Reviews Immunology, vol. 11, no. 2, pp. 98–107, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A.-C. Desfaits, O. Serri, and G. Renier, “Normalization of plasma lipid peroxides, adhesion, and tumor necrosis factor-α production in NIDDM patients after gliclazide treatment,” Diabetes Care, vol. 21, no. 4, pp. 487–493, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Katsuki, Y. Sumida, S. Murashima et al., “Serum levels of tumor necrosis factor-α are increased in obese patients with noninsulin-dependent diabetes mellitus,” Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 3, pp. 859–862, 1998. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Mishima, A. Kuyama, A. Tada, K. Takahashi, T. Ishioka, and M. Kibata, “Relationship between serum tumor necrosis factor-α and insulin resistance in obese men with Type 2 diabetes mellitus,” Diabetes Research and Clinical Practice, vol. 52, no. 2, pp. 119–123, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. G. S. Hotamisligil and B. M. Spiegelman, “Tumor necrosis factor α: a key component of the obesity-diabetes link,” Diabetes, vol. 43, no. 11, pp. 1271–1278, 1994. View at Google Scholar · View at Scopus
  26. M. Soop, H. Duxbury, A. O. Agwunobi et al., “Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans,” American Journal of Physiology—Endocrinology and Metabolism, vol. 282, no. 6, pp. E1276–E1285, 2002. View at Google Scholar · View at Scopus
  27. H. Vlassara and M. R. Palace, “Diabetes and advanced glycation endproducts,” Journal of Internal Medicine, vol. 251, no. 2, pp. 87–101, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Morinaga, T. Ohta, K. Matsui et al., “Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats,” Experimental Diabetes Research, vol. 2009, Article ID 715057, 9 pages, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. U. C. Yadav, S. K. Srivastava, and K. V. Ramana, “Aldose reductase inhibition prevents endotoxin-induced uveitis in rats,” Investigative Ophthalmology and Visual Science, vol. 48, no. 10, pp. 4634–4642, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. N. M. Kalariya, M. Shoeb, N. H. Ansari, S. K. Srivastava, and K. V. Ramana, “Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats,” Investigative Ophthalmology and Visual Science, vol. 53, no. 7, pp. 3431–3440, 2012. View at Publisher · View at Google Scholar · View at Scopus